Biomechanics and Molecular Research on Glioblastoma: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 236
Special Issue Editor
Interests: pharmacology; cancer; toxicology, neuroscience; phytotherapy; cell biology; molecular pharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Despite the considerable advancements in glioma research over the past decade, there remains an urgent and critical need for further investigations aimed at establishing innovative therapeutic and diagnostic targets. Understanding the intricate molecular mechanisms that play a pivotal role in glioma growth and progression, particularly within the supportive tumor microenvironment, is essential for advancing treatment approaches and improving patient outcomes. This Special Issue will place particular emphasis on glioblastoma multiforme (GBM), recognized as one of the most aggressive and lethal types of primary brain tumors. GBM accounts for a staggering 50% of all primary gliomas within the central nervous system, highlighting its significance in neuro-oncology. Recent research has revealed that the mechanical properties of the cellular environment, including the variable stiffness of cancer cells and their surroundings, are crucial factors that influence critical cellular behaviors such as migration, proliferation, and differentiation. These characteristics affect tumor development and may impact the efficacy of existing therapeutic interventions. Therefore, a comprehensive understanding of these biomechanical aspects is paramount for the pursuit of effective GBM treatments. We invite submissions that explore novel molecular pathways implicated in the growth and progression of GBM, offering fresh insights that could inform future therapeutic strategies. In addition, we are particularly interested in research presenting innovative molecules that demonstrate the ability to interfere with GBM growth and recurrence. Such findings are vital as they could lead to the identification of new, promising diagnostic and therapeutic targets, ultimately enhancing the clinical management of this devastating disease.
Dr. Lorenzo Corsi
Guest Editor
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Keywords
- GBM
- molecular pathways
- biomechanics
- oncogene
- cancer
- microenvironment
- drug targeting
- diagnostic
- immunotherapy
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