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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant Hormone Signaling
edited by and Kinga Dziurka
submission deadline 31 Jul 2024 | 1 articles | Viewed by 497 | Submission Open
Keywords: hormonal regulation; cross-talk between phytohormones and other metabolites; signaling; gene expression; defense mechanisms; abiotic and biotic stress; plant growth and development
(This special issue belongs to the Section Molecular Plant Sciences)
Redox Regulation and Drug Discovery
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 428 | Submission Open
Keywords: redox regulation; drug discovery; medical translation; redox biology and medicine; redox homeostasis; redox balance; natural products; redox signaling pathways
(This special issue belongs to the Section Molecular Pharmacology)
Ischemia Reperfusion Injury: A Cell Signaling Crossroads and Therapeutics 2.0
edited by , and Arnau Panisello-Roselló
submission deadline 31 Jul 2024 | 1 articles | Viewed by 399 | Submission Open
Keywords: ischemia– reperfusion injury; transplantation; liver; pancreas; small intestine; HOPE; glycocalyx; inflammation; oxidative and endoplasmic reticulum stress; pharmacological treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stem Cell Applications and Innovations in Developmental and Degenerative Disorders submission deadline 31 Jul 2024 | Viewed by 334 | Submission Open
Keywords: stem cell; degenerative disorders; neurodevelopmental disorders
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Astrocytes in Human Diseases
edited by
submission deadline 31 Jul 2024 | Viewed by 327 | Submission Open
Keywords: astrocytes; glia; health and disease; neurodegeneration; traumatic brain injury; epilepsy; Alzheimer’ s disease; Parkinson’ s disease; neurodevelopment; tripartite synapse
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Review Papers in Molecular Oncology 2024 submission deadline 31 Jul 2024 | Viewed by 327 | Submission Open
Keywords: review; molecular oncology; cancer genetics and epigenetics
(This special issue belongs to the Section Molecular Oncology)
Advancements in Solar Cells and Materials for Photovoltaics 2.0 submission deadline 31 Jul 2024 | Viewed by 325 | Submission Open
Keywords: photovoltaic; materials; solar; perovskite; thin film; efficiency; characterization; degradation
(This special issue belongs to the Section Materials Science)
New Insights into Radiation Oncology
edited by
submission deadline 31 Jul 2024 | Viewed by 320 | Submission Open
Keywords: particle irradiation; proton and carbon ion irradiation; molecular and cellular radiobiology; influence of particle irradiation on physiology and signal transduction cascades of tumor cells; radiation physics; radiation therapy of malignant bone tumors
(This special issue belongs to the Section Molecular Oncology)
Biomarkers of Tumor Progression, Prognosis and Therapy 2.0
edited by
submission deadline 31 Jul 2024 | Viewed by 292 | Submission Open
Keywords: cancer biomarkers; genetic aberrations; carcinogenesis; cancer progression; molecular methods; in silico data analysis; image analysis; proteomics
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicles in Phylogeny 2.0
edited by
submission deadline 31 Jul 2024 | Viewed by 291 | Submission Open
Keywords: extracellular vesicles; phylogeny; immunology; infectious disease; metabolism; longevity; disease resistance; cancer resistance; antibiotic resistance; zoonotic disease; host-pathogen interactions; pathology; veterinary research; wildlife conservation; comparative animal models; biomarkers
(This special issue belongs to the Section Molecular Biophysics)
Autoimmunity Disease and Viral Infections
edited by
submission deadline 31 Jul 2024 | Viewed by 283 | Submission Open
Keywords: autoimmunity; autoimmune diseases; autonomic nervous system; viral infections
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Basis and Therapy of Optic Neuropathies
edited by Steffen Hamann and
submission deadline 31 Jul 2024 | Viewed by 272 | Submission Open
Keywords: compressive optic neuropathy; inflammatory optic neuropathy; ischemic optic neuropathy; glaucoma; hereditary optic neuropathy; neuromyelitis optica spectrum disorder; optic neuropathy; optical coherence tomography imaging; raised intracranial pressure; traumatic optic neuropathy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Macrophages in Cancers
edited by
submission deadline 31 Jul 2024 | Viewed by 272 | Submission Open
Keywords: tumor-associated macrophages; tumor microenvironment; monocytes; cancer; cancer therapy; bisphosphonates; cytokines; chemokines; immune response; therapeutic resistance; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies
edited by
submission deadline 31 Jul 2024 | Viewed by 266 | Submission Open
Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structural and Functional Analysis of Amino Acids and Proteins
edited by and
submission deadline 31 Jul 2024 | Viewed by 264 | Submission Open
Keywords: protein structure; protein function; amino acids network; deep learning; bioinformatics; protein– protein interaction; drug discovery; biomarker
(This special issue belongs to the Section Molecular Informatics)
How Melanin Affects the Therapy Response of Cutaneous Melanoma?
edited by
submission deadline 31 Jul 2024 | Viewed by 262 | Submission Open
Keywords: cutaneous melanoma; melanin; hyperpigmentation; tyrosinase; therapy resistance; molecular medicine; new therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights to Improve Outcomes of Pregnancy Complications
edited by
submission deadline 31 Jul 2024 | Viewed by 243 | Submission Open
Keywords: biomarkers; diagnostics; preeclampsia; HDP; placenta; GDM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathogenesis and Novel Therapeutics in Breast Cancer
edited by
submission deadline 31 Jul 2024 | Viewed by 243 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions
edited by
submission deadline 31 Jul 2024 | Viewed by 242 | Submission Open
Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cytokines in Inflammatory Signaling 2.0
edited by and
submission deadline 31 Jul 2024 | Viewed by 237 | Submission Open
Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Epigenetic Genes, Biomarkers and Immunotherapy in Cancers submission deadline 31 Jul 2024 | Viewed by 227 | Submission Open
Keywords: epigenetics; epigenetic modifications; immunotherapies; immune checkpoint; DNA methylation; histone modifications; epigenetic biomarkers; epidrugs; endogenous retroviruses
(This special issue belongs to the Section Molecular Oncology)
Selected Papers from the 13th International NME Conference: NME/NDPK/AWD 2023
edited by Chris M. Bunce, and Farhat Latif Khanim
submission deadline 31 Jul 2024 | Viewed by 226 | Submission Open
Keywords: NDPK; NME; AWD; cancer; metastasis; development; bioenergetics; cell signalling
(This special issue belongs to the Section Biochemistry)
Extracellular Vesicles in Cancer Prevention and Treatment
edited by and
submission deadline 31 Jul 2024 | Viewed by 221 | Submission Open
Keywords: extracellular vesicles; biomarkers; cancer; prevention; therapy
(This special issue belongs to the Section Biochemistry)
Immunotherapy-Based Combinations in Thoracic Malignancies
edited by
submission deadline 31 Jul 2024 | Viewed by 220 | Submission Open
Keywords: non-small cell lung cancer; small cell lung cancer; malignant pleural mesothelioma; immune checkpoint inhibitor; immune-related adverse events; PD-L1; PD-1; CTLA-4
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Inflammation in the Etiology of Precancerous Lesions, Carcinogenesis and Cancer Treatment
edited by , Leszek Kalinowski and
submission deadline 31 Jul 2024 | Viewed by 219 | Submission Open
Keywords: inflammation cascade in cancer initiation; progression and metastasis; inflammasome proteins; glycation; NOS isoforms; nitric oxide; oxidative and nitroxidative stress; DAMP; TLR; ferroptosis and necrosis in cancer etiology; COVID-19 infection; cancer and neurodegenerative isorders; inflammatory cells and cacer; primary and secondary inflammation cascade cytokines (IL-1; TNFα ; IL-18; IL-8; IL-6); chemokines; and growth factors in cancer; noncoding RNA and other epigenetic mechnisms in cancer; oxidative/nitroxidative-dependent cell signaling; breast; prostate; urogenital; renal; thyroiccolon and esophago-gastric cancers; melanomas; skin diseases associated with cancer; oncogenes; supressor genes; apoptosis; gene dysfunction and cancer; metabolomic; microbiotic; proteomic and genomic changes in cancer; biological drugs in inflammatory diseases and cancer treatment; effects of immunonutrition and microbiotic modulators on the inflammatory infiltration of the tumor microenvironment; neurodegenerative changes in cancer and after cancer treatmet; the regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in carcinogenesis and chronic inflammatory diseases
(This special issue belongs to the Section Molecular Immunology)
Fish Gamete and Embryo Quality: Molecular Advances and Biotechnological Applications
edited by Elias Gustavo Figueroa Villalobos
submission deadline 31 Jul 2024 | Viewed by 218 | Submission Open
Keywords: reproduction; physiology; nutrition; analysis methods; protocols; genomics; transcriptomics; proteomics; ROS; enzymatic activity; spermatozoa; oocytes; embryos; cryopreservation
(This special issue belongs to the Section Molecular Biology)
Inflammatory Signaling Pathways Involved in Gastrointestinal Diseases: Second Edition submission deadline 31 Jul 2024 | Viewed by 210 | Submission Open
Keywords: inflammatory signaling pathways; gastrointestinal diseases; gastrointestinal cancer; inflammatory bowel disease; colonitis; colorectal cancer; cytokine
(This special issue belongs to the Section Molecular Immunology)
Responses to Abiotic and Biotic Stresses of Gene-Edited Crop Plants
edited by
submission deadline 31 Jul 2024 | Viewed by 207 | Submission Open
Keywords: abiotic stresses; biotic stresses; CRISPR-Cas9; genetic engineering; gene editing; crop productivity
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Research on Wound Healing 2.0
edited by
submission deadline 31 Jul 2024 | Viewed by 206 | Submission Open
Keywords: molecular mechanism; signal transduction; microbiota; DNA methylation; histone modifications; micro-RNAs; circRNAs; long noncoding RNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Unfolding Induced by Chemical Agents
edited by and
submission deadline 31 Jul 2024 | Viewed by 198 | Submission Open
Keywords: protein stability; chemical unfolding; denaturing conditions; protein folding; folding pathway; misfolding; conformational flexibility; disordered state; protein aggregation; protein drugs
(This special issue belongs to the Section Biochemistry)
Molecular Advance on Reproduction and Fertility of Aquatic Animals 2.0
edited by Hongtuo Fu and
submission deadline 31 Jul 2024 | Viewed by 188 | Submission Open
Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Nanomedicines against Bacterial Infections
edited by , Nuno Guimarães, and
submission deadline 31 Jul 2024 | Viewed by 188 | Submission Open
Keywords: nanotechnology; nanoparticle; nanocarriers; nanoantibiotic; drug delivery system; targeted delivery; theranostic; infectious diseases; antibacterial agent; antimicrobial resistance; biomedical application
(This special issue belongs to the Section Molecular Nanoscience)
Nanochemistry in the Extracellular Space
edited by Andrea Zendrini
submission deadline 31 Jul 2024 | Viewed by 188 | Submission Open
Keywords: extracellular nanoparticles; extracellular vesicles; lipoproteins; biomolecular corona; lipid nanoparticles; nanoplastics
(This special issue belongs to the Section Molecular Biology)
Molecular Targeted Therapy for Gliomas
edited by Ka-Kit Leung
submission deadline 31 Jul 2024 | Viewed by 184 | Submission Open
Keywords: targeted therapy; glioma and glioblastoma; treatment strategies; identification of biomarkers; diagnosis; prognosis; molecular pathology; signalling pathways; molecular imaging; tumour microenvironment
(This special issue belongs to the Section Molecular Oncology)
Material Solution Strategies for Implant-Related Infections
edited by Ke Yang
submission deadline 31 Jul 2024 | Viewed by 177 | Submission Open
Keywords: implant; infection; material design; antibacterial material; medical application
(This special issue belongs to the Section Materials Science)
Latest Review Papers in Molecular Informatics 2024
edited by
submission deadline 31 Jul 2024 | Viewed by 175 | Submission Open
Keywords: drug discovery and chemical biology; protein and nucleic acid engineering and design; the design of nanomolecular structures; strategies for modeling of macromolecular assemblies; molecular networks and systems; pharmaco- and chemogenomics; chemical information systems; toolboxes and software packages; database construction; web-based platforms and tools and novel algorithms; computer-aided drug design; QSAR; QSPR; and data mining techniques; molecular docking and virtual screening; molecular modeling; molecular dynamics simulations; free energy calculations; genome assembling; annotation; and integrated analysis; comparative genomics; sequence analysis; analysis and modelling of complex systems
(This special issue belongs to the Section Molecular Informatics)
Interactions between the Nervous System and Gastrointestinal Motility
edited by Takahiko Shiina
submission deadline 31 Jul 2024 | Viewed by 174 | Submission Open
Keywords: gastrointestinal tracts; central nervous system; enteric nervous system; motor regulation; peristalsis; vomiting; gastrointestinal disorder; smooth muscle; striated muscle; sphincter; esophagus; stomach; duodenum; jejunum; ileum; cecum; colon; rectum; rumen
(This special issue belongs to the Section Molecular Neurobiology)
Inflammaging and Brain Aging
edited by and David C. Hess
submission deadline 31 Jul 2024 | Viewed by 171 | Submission Open
Keywords: inflammaging; brain aging; aging; senescence; CNS; immunobiography; age-related diseases
(This special issue belongs to the Section Molecular Neurobiology)
Proteomics of Human Peripheral Blood Mononuclear Cells in Cancer
edited by Ján Sabo
submission deadline 31 Jul 2024 | Viewed by 167 | Submission Open
Keywords: clinical proteomics; cancer; immune response; peripheral blood mononuclear cells (PBMC); CD8+ T cells in PBMC; CD4+ T cells in PBMC; B cells in PBMC; monocytes in PBMC; NK cells in PBMC; dendritic cells in PBMC; biomarker discovery
(This special issue belongs to the Section Molecular Oncology)
New Insights into Cancer Metabolism: Signaling Pathways and Therapeutic Targets submission deadline 31 Jul 2024 | Viewed by 163 | Submission Open
Keywords: cancer metabolism; signaling pathways; therapeutic targets; chemoresistance; microdomains
(This special issue belongs to the Section Molecular Oncology)
Glycoscience in Neurodegenerative Disorders
edited by
submission deadline 31 Jul 2024 | Viewed by 160 | Submission Open
Keywords: neurodegenerative disorders; neurogenetics; pathogenesis; therapy; glycoscience
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanism of Pollen and Pollen Tube Development
edited by Yujin Kim
submission deadline 31 Jul 2024 | Viewed by 160 | Submission Open
Keywords: plant physiology; pollen tube growth; reproductive development
(This special issue belongs to the Section Molecular Plant Sciences)
Cutting-Edge Research and Applications of Extracellular Microvesicles in Disease Management
edited by María Isabel Torres
submission deadline 31 Jul 2024 | Viewed by 149 | Submission Open
Keywords: extraccellular microvesicles; exosome; ectosoma; biomarkers; cargoes of extracellular vesicles; therapeutics; diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Protein-Graphene Supramolecular Assemblies
edited by
submission deadline 31 Jul 2024 | Viewed by 144 | Submission Open
Keywords: protein supramolecular assemblies; protein-2D materials nanostructures  ; tailored molecular interactions; sequencing; sensing; detection
(This special issue belongs to the Section Biochemistry)
Molecular Pathogenesis and Therapeutics in Retinopathy
edited by Fabiana Picconi
submission deadline 31 Jul 2024 | Viewed by 144 | Submission Open
Keywords: retinal neurodegeneration; retinal neurovascular unit; diabetic retinopathy; diabetic neuropathy; diabetic milieu; glucose variability
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Natural Compound for Wound and Tissue Repair and Regeneration 3.0 submission deadline 31 Jul 2024 | Viewed by 140 | Submission Open
Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring the Therapeutic Potential of Modulators of Regulated Cell Death for Retinal Atrophy
edited by Marcelo Nociari
submission deadline 31 Jul 2024 | Viewed by 139 | Submission Open
Keywords: Stargardt disease; dry-age related macular degeneration; cell death; atrophy; regulated necrosis; apoptosis; autophagy; proteostasis; lipofuscin
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Role of Oxidative Stress in Inflammatory Diseases 2.0
edited by
submission deadline 31 Jul 2024 | Viewed by 137 | Submission Open
Keywords: oxidative stress; inflammation; endogenous antioxidant enzymes
(This special issue belongs to the Section Molecular Immunology)
Microsatellite Instability: From Molecular Mechanisms to Repeat Expansion Diseases
edited by
submission deadline 31 Jul 2024 | Viewed by 134 | Submission Open
Keywords: microsatellite; DNA instability; DNA replication; DNA repair; DNA Recombination; replication slippage; misalignment; repeat expansion; trinucleotide repeats; genetic anticipation; dynamic mutations; fragile X syndrome; Huntington's disease; Friedreich’ s ataxia
(This special issue belongs to the Section Molecular Genetics and Genomics)
Research of Mitochondrial Function, Structure, Dynamics and Intracellular Organization: 3rd Edition submission deadline 31 Jul 2024 | Viewed by 134 | Submission Open
Keywords: confocal fluorescent imaging; mitochondria; energy metabolism; mitochondrial function; mitochondrial dynamics; mitochondrial intracellular organization; heterogeneity; metabolic diseases; reactive oxygen species; signaling
(This special issue belongs to the Section Molecular Biology)
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