Molecular Insights in Renal and Epithelial Physiology

Dear Colleagues,

In order to maintain the balance between fluids and electrolytes, ions in the glomerular filtrate are transported from the renal tubular lumen to the basolateral surface in all nephron segments. Ions can also be transported from the intracellular space into the tubular lumen.  Molecular structures and site-directed mutagenesis have uncovered the mechanisms by which ion transport occurs. The expression and function of these transporters or exchangers can also be controlled by genetic (e.g., miRNA), metabolic (e.g., proteasome degradations), and other intracellular (membrane localization) and extracellular factors (e.g., extracellular vesicles). The paracellular flux of these ions can also be controlled by tight junctions and influenced by modifiers of ion transport, such as age, environment, exercise, and sex. This collection of reviews and new reports will provide new molecular insights into renal and epithelial physiology.

Dr. Pedro A. Jose
Guest Editor

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