T Cell Malignancies: Translating Basic Research into Better Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 10
Special Issue Editor
Interests: leukemia; lymphoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
T-cell malignancies pose significant challenges to effective therapy due to their heterogeneity and complexity. In contrast to B-cell malignancies, which have a very good prognosis with conventional chemotherapy and more specific approaches such as monoclonal antibodies and CAR-T cell therapy, no comparable advances have been seen in T-cell neoplasms. This is mostly due to a lack of specific target antigens on malignant T cells and fratricide (killing of engineered T cells by other engineered T cells). To improve the prognosis in T-cell malignancies, new, gene-targeted therapies have to be developed.
The aim of this Special Issue is to report novel genomic, transcriptomic, or proteomic alterations in T-cell malignancies and functional studies on their contribution to cancer development, which may have a potential therapeutic use.
Original articles, short communication, and review papers are welcome.
Prof. Dr. Grzegorz Przybylski
Guest Editor
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Keywords
- T-Cell malignancies
- specific target antigens
- gene-targeted therapies
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