Biology of Oral Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 10 December 2025 | Viewed by 113
Special Issue Editor
Interests: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy
Special Issue Information
Dear Colleagues,
Oral cancer remains a significant global health challenge, with an increasing incidence and high mortality rates despite advancements in therapy. Recent progress in molecular biology has provided deeper insights into genetic and epigenetic alterations driving oral carcinogenesis, tumor progression, and treatment resistance. This Special Issue of IJMS aims to provide a comprehensive platform for the latest research on the molecular mechanisms underlying oral cancer biology.
We particularly welcome original research and review articles focusing on the following areas:
- Genomic and epigenetic alterations in oral cancer initiation and progression.
- Novel molecular biomarkers for early detection and prognosis.
- Mechanisms of therapy resistance and tumor recurrence.
- Interactions between oral microbiome and cancer development.
- Tumor microenvironment and immune evasion strategies.
- Emerging targeted therapies and immunotherapeutic approaches.
- Liquid biopsy applications in oral cancer management.
- Molecular pathways of field cancerization and premalignant lesions.
This Special Issue is supervised by Dr. Rafał Pęksa and assisted by our Topical Advisory Panel Member Dr. Paulina Adamska (Medical University of Gdańsk, https://www.mdpi.com/journal/ijms/topical_advisory_panel?search=Paulina+Adamska).
This Special Issue encourages interdisciplinary approaches combining molecular biology, pathology, immunology, and clinical research to promote the comprehensive understanding of oral cancer biology. We particularly value studies that bridge fundamental molecular discoveries with potential clinical applications, advancing the field toward precision oncology for oral cancer patients.
Research utilizing cutting-edge technologies, such as single-cell sequencing, spatial transcriptomics, multi-omics integration, and artificial intelligence applications, is especially encouraged to uncover novel insights into oral cancer biology and therapeutic vulnerabilities. By emphasizing molecular-level findings, this Special Issue offers a valuable resource for researchers and clinicians striving to improve diagnostic accuracy and therapeutic efficacy in oral cancer management.
Dr. Rafał Pęksa
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- oral cancer
- molecular mechanisms
- biomarkers
- tumor microenvironment
- therapy resistance
- precision medicine
- carcinogenesis
- oral squamous cell carcinoma
- epigenetics
- microbiome
- immunotherapy
- liquid biopsy
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