Ion Regulation in Human Pathophysiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 22
Special Issue Editor
Interests: red blood cells; ion channels; calcium signaling; microscopy; hematology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ion gradients across the cell membrane are fundamental to numerous physiological and pathophysiological processes that govern cellular function. Dysregulation of ion conductance and ion homeostasis is implicated in a variety of diseases, including neurological disorders, muscular dysfunction, and hematological abnormalities. A comprehensive understanding of ion transport mechanisms is therefore critical for advancing insights into both normal cellular physiology and disease pathology. This Special Issue explores the structures and functions of ion transport across membranes, emphasizing pathological conditions arising from ion imbalance. A key focus includes ion regulation within intracellular stores and signaling pathways that govern ion dynamics in both health and disease. Studies addressing excitable cells—such as neurons, where ion flux influences synaptic transmission and neurodegeneration, and myocytes, where ion handling is crucial for muscle contraction and cardiomyopathies—are highly encouraged. Additionally, research on non-excitable cells, including erythrocytes, where altered ion permeability contributes to hemolytic disorders, and other cell types involved in ion-mediated regulatory mechanisms, is welcome. This Special Issue invites original research and comprehensive reviews, encompassing work on model systems, cell lines, primary cells, and tissues. Contributions shedding light on disease-associated ion dysregulation, novel therapeutic targets, and mechanistic insights into ion transport are especially valued.
Prof. Dr. Lars Kaestner
Guest Editor
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Keywords
- ion channels
- ion gradients
- membrane potential
- action potential
- ion pumps
- uniporter
- co-transporter
- patch-clamp
- ion flux
- concentration gradient
- ion stores
- physiological processes
- pathophysiological processes
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