Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 26
Special Issue Editor
Special Issue Information
Dear Colleagues,
The cells of an organism communicate with each other through the controlled release of signaling substances into the immediate and extended environment and through the recognition and interpretation of these extracellular messengers. In this way, important cellular functions such as proliferation are coordinated according to cues inside and outside the immediate neighborhood.
Our knowledge concerning the network controlling cell proliferation is largely based on experiments using two-dimensional in vitro cell cultures recognizing the limitations of these culturing conditions, and the optimization of the culturing methods including a third dimension is considered to better mimic conditions in vivo.
This Special Issue aims to gather observations concerning the interpretation of signals in different versions of 3D cultures, preferably in comparison with conventional 2D cultures. In this way, findings concerning signal transduction mechanisms due to different cell cultivation methods can be combined, and we can expand our understanding of signal interpretation in multiple research areas.
This Special Issue welcomes manuscripts addressing the intracellular communication of proliferation signals of cells in two- and three-dimensional cultures.
Dr. Hedwig Sutterluety-Fall
Guest Editor
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Keywords
- proliferation
- signaling
- two-dimensional
- three-dimensional
- cell culturing
- in vitro
- growth factors
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