Chronic Kidney Disease: Underlying Molecular Mechanisms – 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025
Special Issue Editors
Interests: inflammation; oxidative stress; cardiovascular risk factors; pre-eclampsia; chronic kidney disease; obesity
Special Issues, Collections and Topics in MDPI journals
Interests: toxicology; drugs of abuse; amphetamines; synthetic cathinones; psychoactive substances; toxicometabolomics; cancer metabolomics; biomarkers; hepatotoxicity; nephrotoxicity; cardiotoxicity; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) has become a pressing global health issue, warranting international attention. It is defined by the presence of structural or functional abnormalities in the kidneys persisting for at least three months. The global increase in CKD prevalence parallels rising human longevity and a growing burden of both traditional and non-traditional risk factors. In addition to well-known contributors such as obesity and diabetes, environmental factors (e.g., pesticides and heavy metals) are increasingly recognized as important drivers of CKD.
CKD is linked to substantial comorbidity and mortality and imposes significant economic burdens on healthcare systems worldwide. A deeper understanding of the disease’s underlying mechanisms is essential for developing effective preventive strategies and novel therapeutics aimed at delaying onset and progression. Moreover, insights into CKD pathophysiology are critical for identifying early biomarkers, which are key to timely clinical intervention.
This Special Issue seeks to highlight the latest research in the following areas:
a) Molecular mechanisms involved in the pathophysiology of CKD and its comorbidities;
b) Emerging methodological approaches, including omics technologies, to unravel CKD-related molecular pathways and discover novel biomarkers;
c) Pharmacological and non-pharmacological strategies for prevention;
d) Mechanistic links between CKD and other health conditions, such as cancer.
We welcome your contributions to advance the understanding and management of CKD.
Dr. Luís Belo
Dr. Márcia Carvalho
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chronic kidney disease
- molecular mechanisms
- toxicity mechanisms
- inflammation
- environmental factors
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