Chronic Kidney Disease: Underlying Molecular Mechanisms—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 698
Editors
Interests: inflammation; oxidative stress; cardiovascular risk factors; pre-eclampsia; chronic kidney disease; obesity
Special Issues, Collections and Topics in MDPI journals
Interests: toxicology; drugs of abuse; amphetamines; synthetic cathinones; psychoactive substances; toxicometabolomics; cancer metabolomics; biomarkers; hepatotoxicity; nephrotoxicity; cardiotoxicity; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) has become a pressing global health issue, warranting international attention. It is defined by the presence of structural or functional abnormalities in the kidneys persisting for at least three months. The global increase in CKD prevalence parallels rising human longevity and a growing burden of both traditional and non-traditional risk factors. In addition to well-known contributors such as obesity and diabetes, environmental factors (e.g., pesticides and heavy metals) are increasingly recognized as important drivers of CKD.
CKD is linked to substantial comorbidity and mortality and imposes significant economic burdens on healthcare systems worldwide. A deeper understanding of the disease’s underlying mechanisms is essential for developing effective preventive strategies and novel therapeutics aimed at delaying onset and progression. Moreover, insights into CKD pathophysiology are critical for identifying early biomarkers, which are key to timely clinical intervention.
This Special Issue seeks to highlight the latest research in the following areas:
- Molecular mechanisms involved in the pathophysiology of CKD and its comorbidities;
- Emerging methodological approaches, including omics technologies, to unravel CKD-related molecular pathways and discover novel biomarkers;
- Pharmacological and non-pharmacological strategies for prevention;
- Mechanistic links between CKD and other health conditions, such as cancer.
We welcome your contributions to advance the understanding and management of CKD.
Dr. Luís Belo
Dr. Márcia Carvalho
Guest Editors
Manuscript Submission Information
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Keywords
- chronic kidney disease
- molecular mechanisms
- toxicity mechanisms
- inflammation
- environmental factors
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