Current Treatment Models in Hepatocellular Carcinomas
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 32
Special Issue Editor
Interests: liver and biliary oncology; liver transplantation; liver cirrhosis; autoimmune and cholestatic disorders of the liver
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hepatocellular carcinoma (HCC) is one of the most clinically unpredictable malignant tumors, and it remains one of the leading causes of death from all types of cancers. Usually, it shows late clinical signs in the advanced stages of the disease, which results in a frequent delay in diagnosis. The prognosis for HCC remains poor despite multidisciplinary medical approach and many therapeutic advances. Still, surgical resection and liver transplantation remain the main methods of radical treatment for HCC. In recent years, combining several treatment methods in one patient parallelly, advanced locoregional interventional therapies and new targeted immunotherapies, have become increasingly important, especially for patients in advanced stages of the disease. Clearly, the translational approach from molecular mechanisms and cellular microenvironment to clinical practice is crucial in the management of patients with HCC. However, we still do not have modern “miraculous” drugs and procedures available, that would allow us to prolong life of great majority of our HCC patients for many years – there is still much to be done.
This Special Issue is designed to summarize all the recent knowledge on different treatment options for HCC and to create an opportunity to exchange own experiences of leading centers taking care of patients with HCC, including the advances in molecular pathogenesis of liver tumors, immunotherapy and newest treatment procedures in HCC, with all the clinical implications and also, some recent research directions in that matter. We encourage authors to publish articles both in the field of clinical and laboratory science, particularly emphasizing the connection between molecular medicine and everyday clinical practice, to achieve the best cross-sectional scientific effect of this Special Issue.
Dr. Michał P. Wasilewicz
Guest Editor
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Keywords
- hepatocellular carcinoma (HCC)
- liver tumors
- liver cancer
- molecular mechanisms
- systemic therapies
- immunochemotherapy
- immunotherapy
- adjuvant therapy
- neoadjuvant therapy
- hepatocellular carcinoma microenvironment
- liver resection/liver transplantation in HCC
- microwave ablation (MWA)
- transarterial chemoembolisation (TACE)
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