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Molecular Insights into Microbial Adaptations to Marine Plastics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 954

Special Issue Editor

Molecular Biology Department, Ariel University, Ariel, Israel
Interests: hydrocarbonoclastic bacteria; platisphere; marine pollution; non-classical immune systems

Special Issue Information

Dear Colleagues,

The growing accumulation of plastic debris in marine environments has led to the emergence of a unique ecosystem known as the "plastisphere". This special issue aims to explore the complex biological, chemical, and ecological dimensions of the microbiome developed on marine plastic surfaces. We invite original research and review articles that investigate the diversity, adaptations, interactions, and ecological consequences of microbes associated with marine plastics with an emphasis on molecular mechanisms and functional insights. Contributions may include, but are not limited to:

  • Molecular adaptations of bacteria, archaea, and eukaryotic microbes to plastic surfaces
  • Succession and species interactions within the plastisphere
  • Microbial degradation of plastics and metabolic pathways involved
  • Roles of the plastisphere in biogeochemical cycling
  • Microbe–plastic–host interactions (e.g., pathogens, symbionts, vectors)
  • Horizontal gene transfer, antibiotic resistance, and functional gene exchange within plastisphere biofilms

We particularly welcome studies that integrate omics approaches (metagenomics, transcriptomics, proteomics), experimental systems, in situ observations, and modeling. By bringing together interdisciplinary perspectives, this issue seeks to advance our understanding of how microbial life interacts with synthetic substrates and influences marine ecological processes.

Dr. Matan Oren
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • plastisphere
  • marine plastic debris
  • microbial colonization
  • biofilms
  • microbial adaptation
  • community assembly
  • quorum sesing
  • plastic biodegradation
  • biogeochemical cycling
  • antibiotic resistance genes
  • marine microbial ecology
  • metagenomics
  • microbe–plastic interactions
  • microbial succession

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Published Papers (1 paper)

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Research

16 pages, 2311 KB  
Article
High Cell Density Fermentation of Yarrowia lipolytica on n-Hexadecane for the Valorization of Pyrolyzed Plastic Waste
by Antonia Keil, Joost Woestenborghs, Oleksii Lyzak, Elodie Vlaeminck, Evelien Uitterhaegen, Karel De Winter, Kevin J. Verstrepen and Wim Soetaert
Int. J. Mol. Sci. 2026, 27(2), 1107; https://doi.org/10.3390/ijms27021107 - 22 Jan 2026
Viewed by 686
Abstract
The recycling of fossil-based plastic waste remains a key challenge in reducing environmental pollution and greenhouse gas emissions. An innovative approach is the biotechnological conversion of the n-alkane mixture obtained from thermal pyrolysis of plastic waste. This study focuses on the use of [...] Read more.
The recycling of fossil-based plastic waste remains a key challenge in reducing environmental pollution and greenhouse gas emissions. An innovative approach is the biotechnological conversion of the n-alkane mixture obtained from thermal pyrolysis of plastic waste. This study focuses on the use of the oleaginous yeast Yarrowia lipolytica for the valorization of polyethylene (PE)-derived pyrolysis oil. From a screening of 50 Y. lipolytica strains, the most promising candidate was selected, and its single-cell phenotype was stabilized by MHY1 deletion. In shake flask experiments, this strain grew similarly on 5–20 vol% of n-hexadecane, revealing no inhibitory effects. Subsequently, a high cell density fermentation was established in a 4 L bioreactor using a pulsed fed-batch approach, resulting in biomass concentrations of up to 145.6 g·L−1, which contained 22.0% triacylglycerols. In addition, cultivation at pH 2.5, compared to pH 4.0, reduced citrate formation from 95.6 to 0.8 g·L−1, while biomass and TAG titers remained similar. Overall, these results highlight the potential of integrating plastic waste-derived pyrolysis oil into future bioprocesses using Y. lipolytica as an effective platform for high cell density production. Full article
(This article belongs to the Special Issue Molecular Insights into Microbial Adaptations to Marine Plastics)
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