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Novel Cell Signaling Targets and Mechanism for Effective Individualized Therapies

Special Issue Editor


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Guest Editor
Department of Laboratory Medicine, Chiba University Hospital, Chiba, Japan
Interests: cancer; clinical laboratory; molecular science; rare diseases; ribosome
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Special Issue Information

Dear Colleagues,

In the field of cancer treatment, drugs targeting intracellular signals have been effective. However, in addition to the currently known cancer addiction pathways that are enhanced in cancer cells, it is believed that there are undiscovered pathways and new molecular targets hidden. In this Special Issue, we will introduce the latest promising findings on novel cell signaling targets and mechanisms for effective individualized therapies that will lead to future therapeutic applications and cancer diagnosis.

Dr. Kazuyuki Matsushita
Guest Editor

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Keywords

  • novel cell signaling targets
  • individualized therapies
  • addiction signal pathway
  • diagnosis and treatment
  • cancer
  • neurodegenerative diseases
  • cell development

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Published Papers (1 paper)

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Review

24 pages, 2268 KB  
Review
FIR/PUF60: Multifunctional Molecule Through RNA Splicing for Revealing the Novel Disease Mechanism and Effective Individualized Therapies
by Kazuyuki Matsushita, Kouichi Kitamura, Nobuko Tanaka, Sohei Kobayashi, Yusuke Suenaga and Tyuji Hoshino
Int. J. Mol. Sci. 2026, 27(2), 643; https://doi.org/10.3390/ijms27020643 - 8 Jan 2026
Viewed by 746
Abstract
Disease-specific diversity in RNA transcripts stems from RNA splicing, ribosomal abnormalities, and other factors. However, the mechanisms underlying the regulation of rRNA expression in the nucleolus and mRNA expression in the cytoplasm during cancer and neuronal differentiation remain largely unknown. In this article, [...] Read more.
Disease-specific diversity in RNA transcripts stems from RNA splicing, ribosomal abnormalities, and other factors. However, the mechanisms underlying the regulation of rRNA expression in the nucleolus and mRNA expression in the cytoplasm during cancer and neuronal differentiation remain largely unknown. In this article, we review current knowledge and discuss the regulatory mechanisms of rRNA and mRNA expression in human diseases using the splicing model of PUF60 (poly(U) binding splicing factor 60)—also known as FUSE-binding protein-interacting repressor (FIR) (FUBP1-interacting repressor), RoBPI, SIAHBP1, and VRJS (Gene ID: 22827). Noncoding RNAs, much like coding RNAs, have been found to be translated into proteins with significant physiological functions. Splicing is also involved in dominant ORF RNAs implicated in the expression of both noncoding and coding RNAs. Here, we analyze recent findings regarding gene splicing, ribosome formation, and the determination of selected ORFs (dominant ORFs) in a system modeled on FIR splicing in two databases (RefSeq and ENSEMBL). rRNA transcription affects ribosomes, whereas mRNA expression and splicing affect the intracellular proteome. Our objective is to develop efficient methods for identifying biomarkers for disease diagnosis and therapeutic targets. In the field of cancer treatment, therapeutic drugs targeting intracellular signaling have proven effective. Full article
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