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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Molecular Breeding for Drought and Salt Stress Tolerance in Crops: 2nd Edition

edited by

Zhaoshi Xu

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4635 | Submission Open

Keywords: drought; salt; heat; cold; gene regulation; genomic research; multiomics; epigenetics; stress signal transduction

(This special issue belongs to the Section Molecular Plant Sciences)

Wheat Genetics and Genomics: 3rd Edition

edited by

Xiaojun Nie

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4327 | Submission Open

Keywords: wheat; genetics; molecular breeding; genome variation; multiomics

(This special issue belongs to the Section Molecular Plant Sciences)

Prostate Cancer Research Update: Molecular Diagnostic Biomarkers

edited by Mikhail Baryshev

submission deadline 20 Apr 2026 | 3 articles | Viewed by 4245 | Submission Open

Keywords: prostate cancer; molecular biomarkers; cancer-specific DNA methylation; non-coding genes; gene fusions; lncRNA

(This special issue belongs to the Section Molecular Oncology)

Advances in Tea Tree Genetics and Breeding: 2nd Edition

edited by

Mingzhe Yao

and

Kang Wei

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4114 | Submission Open

Keywords: tea plant (Camellia sinensis); molecular mechanism; secondary metabolites; stress response; quality-related component; genes identification; QTL mapping; molecular functional markers

(This special issue belongs to the Section Molecular Plant Sciences)

Protein Folding, Misfolding, and Related Diseases

edited by

Ludmilla Morozova-Roche

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3343 | Submission Open

Keywords: protein folding; misfolding; amyloid; neurodegenerative diseases; chaperons; mechanisms; regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cells in Health and Disease: 3rd Edition

edited by

Maja Ludvigsen

submission deadline 20 Apr 2026 | 2 articles | Viewed by 3002 | Submission Open

Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity

(This special issue belongs to the Section Molecular Biology)

Developmental and Reproductive Toxicology

edited by

Hyun-Jung Park

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2870 | Submission Open

Keywords: spermatogenesis; mouse models; reproduction biology; assisted reproductive technology; cell signaling; cellular biology; developmental biology

(This special issue belongs to the Section Molecular Biology)

Molecular Characterization and Applications of Nanomaterials in Nanomedicine and Cancer Therapy

edited by

Costica Caizer

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1893 | Submission Open

Keywords: nanomaterials (preparation methods; characterization techniques; properties); theoretical studies of nanomaterials and computational simulations; biocompatibility and biofunctionalization; applications in nanomedicine; applications in cancer therapy; drug delivery; nanoparticle imaging; magnetic resonance imaging (MRI); contrast agents; nanotheranostics

(This special issue belongs to the Section Molecular Nanoscience)

Techniques and Strategies in Drug Design and Discovery, 3rd Edition

edited by

George Mihai Nitulescu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1769 | Submission Open

Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1563 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Interplay of Metabolism and Inflammation in Gastrointestinal Disease

edited by Marios Papadakis and

Stavros P. Papadakos

submission deadline 20 Apr 2026 | Viewed by 1487 | Submission Open

Keywords: gastrointestinal diseases; inflammation; metabolic dysregulation; metabolic processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthetic Chemistry in Drug Discovery

edited by Kathiravan Suppan

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1206 | Submission Open

Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis

(This special issue belongs to the Section Molecular Pharmacology)

Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches

edited by Francisco Giner

submission deadline 20 Apr 2026 | 1 articles | Viewed by 958 | Submission Open

Keywords: coeliac disease; microscopic colitis; Crohn’ s disease; ulcerative colitis; microbiota; biological therapies; refractory disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 20 Apr 2026 | 1 articles | Viewed by 669 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Impact of the Biological Clock on Health and Disease

edited by

Bojlul Bahar

submission deadline 20 Apr 2026 | Viewed by 423 | Submission Open

Keywords: circadian rhythm; inflammation; oxidative stress; energy balance; metabolic syndrome; ageing; cancer; diabetes; obesity; entrainment; synchrony; melatonin

(This special issue belongs to the Section Molecular Biology)

Research Progress of Orthopedic Materials

edited by Robert Karpiński

submission deadline 20 Apr 2026 | Viewed by 314 | Submission Open

Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings

(This special issue belongs to the Section Materials Science)

Neurotoxicity: Cellular Death Mechanisms in the Pathogenesis of Neurodegenerative Diseases

edited by

Md. Jakaria

and

Jason Cannon

submission deadline 20 Apr 2026 | Viewed by 229 | Submission Open

Keywords: neurotoxicity; cellular stress; neuronal cell death; ferroptosis; neurodegeneration; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Diagnosis and Treatments of Diabetes Mellitus: 2nd Edition

edited by

Mihail Virgil Boldeanu

submission deadline 20 Apr 2026 | Viewed by 203 | Submission Open

Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 20 Apr 2026 | Viewed by 202 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell– cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Psychobiotics as Next-Generation Probiotics: A Holistic Approach to Mental Health and Gut–Brain Axis Modulation

edited by

Edyta Juszczuk-Kubiak

submission deadline 20 Apr 2026 | Viewed by 171 | Submission Open

Keywords: probiotics; gut microbiota; gut– brain axis; mental health

(This special issue belongs to the Section Molecular Biology)

Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Apr 2026 | Viewed by 161 | Submission Open

Keywords: gut– brain axis; gut– heart axis; gut– liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery

edited by

Adelina-Gabriela Niculescu

and

Alexandra Catalina Birca

submission deadline 20 Apr 2026 | Viewed by 153 | Submission Open

Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine

(This special issue belongs to the Section Molecular Nanoscience)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 20 Apr 2026 | Viewed by 150 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

Protection of Natural Products in Liver Injury

edited by

Jeon-Ok Moon

submission deadline 20 Apr 2026 | Viewed by 148 | Submission Open

Keywords: liver injury; natural product; antioxidant activity; modulation of inflammatory pathway; mitigation of fibrosis; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Food Allergens: Latest Molecular Advancements

edited by

Zhihua Wu

and

Anshu Yang

submission deadline 24 Apr 2026 | Viewed by 92 | Submission Open

Keywords: food allergies; allergen; allergenicity; epitope; desensitization; immunity reaction; hypoallergen; Ig E binding

(This special issue belongs to the Section Molecular Biology)

Innovations in Functional Biomaterials for Biomedical Applications

edited by

Arpita Roy

submission deadline 25 Apr 2026 | Viewed by 32 | Submission Open

Keywords: functional biomaterials; molecular mechanisms; drug delivery systems; tissue engineering; biointerface interactions; smart/stimuli-responsive materials; molecular modeling and simulation; gene and protein expression; biomolecular characterization; regenerative medicine

(This special issue belongs to the Section Materials Science)

Nanomaterials and Regulated Cell Death Pathways: Novel Therapeutic Opportunities

edited by

Anton S. Tkachenko

submission deadline 25 Apr 2026 | Viewed by 13 | Submission Open

Keywords: apoptosis; ferroptosis; nanotherapy; nanotoxicity; necroptosis; oxidative stress; PANoptosis; pyroptosis; regulated cell death

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Ophthalmic Diseases

edited by

Alicja Forma

submission deadline 27 Apr 2026 | Viewed by 47 | Submission Open

Keywords: environmental hazards; ophthalmic diseases; molecular mechanisms; risk factors; disease prevention; oxidative stress; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advance in Nutraceutical Research: From Bioactive Discovery to Translational Application

edited by

Alessandro Colletti

submission deadline 27 Apr 2026 | Viewed by 21 | Submission Open

Keywords: bioactive compounds; nutraceuticals; molecular mechanisms; nutraceutical formulations; preclinical and clinical validation; targeted delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Toxicity: Identifying Biomarkers and Molecular Pathways Involved in Toxicological Responses

edited by Irma Martha Medina Díaz

submission deadline 29 Apr 2026 | 1 articles | Viewed by 921 | Submission Open

Keywords: biomarkers; molecular pathways; chemical exposure assessment; environmental exposure; human health; public health toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Cardiac Development and Disease (Second Edition)

edited by

Kay-Dietrich Wagner

submission deadline 29 Apr 2026 | Viewed by 31 | Submission Open

Keywords: cardiac development; cardiac repair; regeneration; cardiac cell-cell interaction; fibrosis; remodeling; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Therapeutic Innovations in Neuromuscular Diseases

edited by

Virginia Arechavala Gomeza

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: neuromuscular disorders; molecular mechanisms; gene therapies; RNA therapies; small molecules

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gene Therapy for Ocular Diseases: Mechanisms, Advances and Therapeutic Applications

edited by Jiang-Hui Wang

submission deadline 30 Apr 2026 | Viewed by 10 | Submission Open

Keywords: AAV; capsid engineering; gene therapy; retinal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computer Simulation Insight Into Ligand-Receptor Interaction

edited by

Antonis Drakopoulos

submission deadline 30 Apr 2026 | Viewed by 4 | Submission Open

Keywords: structure– activity relationship (SAR); free energy perturbation (FEP); structure-based drug design (SBDD); machine learning in drug discovery; hybrid qm/mm methods; binding affinity prediction; enhanced sampling techniques; target binding kinetics

(This special issue belongs to the Section Molecular Informatics)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 May 2026 | 6 articles | Viewed by 19185 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Fascial Anatomy and Histology: Advances in Molecular Biology

edited by

Carla Stecco

submission deadline 20 May 2026 | 4 articles | Viewed by 15396 | Submission Open

Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan

(This special issue belongs to the Section Molecular Biology)

Pathogenesis and Novel Therapeutic Approaches for Sarcomas

edited by Francisco Giner

submission deadline 20 May 2026 | 4 articles | Viewed by 8237 | Submission Open

Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Organelle Stress Responses and Implications in Human Diseases

edited by

Jaeseok Han

submission deadline 20 May 2026 | 2 articles | Viewed by 1553 | Submission Open

Keywords: organelle stresses; mitochondria; ER; lysosome; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pancreatic Diseases: Molecular Pathology and Therapeutics

edited by

Maria Ines Vaccaro

submission deadline 20 May 2026 | 1 articles | Viewed by 839 | Submission Open

Keywords: pancreatic cancer; acute pancreatitis; chronic pancreatitis; diabetes; inflammation; molecular markers; therapeutic strategies; genetic predispositions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies

edited by

Siu Hong Dexter Wong

and Bohan Yin

submission deadline 20 May 2026 | Viewed by 510 | Submission Open

Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release

(This special issue belongs to the Section Macromolecules)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 20 May 2026 | Viewed by 132 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Nutrition of Crustaceans: A Molecular Perspective

edited by

Cheng Chi

submission deadline 25 May 2026 | Viewed by 13 | Submission Open

Keywords: crustacean nutrition; molecular mechanisms; aquaculture; nutrient metabolism; reproduction

(This special issue belongs to the Section Molecular Biology)

Virus Detection and Analysis: Molecular Investigations

edited by

Hayes Kam-Hei Luk

submission deadline 26 May 2026 | Submission Open

Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing

(This special issue belongs to the Section Molecular Microbiology)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 30 May 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Reproductive Medicine

edited by Wei Chen

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1638 | Submission Open

Keywords: spermatogenesis; oogenesis; microenvironment; organ interactions; molecular regulation; gametogenesis; signaling pathways; reproductive disorders

(This special issue belongs to the Section Molecular Biology)

Glycoconjugates: From Structure to Therapeutic Application

edited by Rosana Ribić

submission deadline 20 Jun 2026 | 1 articles | Viewed by 776 | Submission Open

Keywords: glycoconjugates (glycoproteins and glycopeptides; glycolipids; proteoglycans); glyconanoparticles; carbohydrate-based therapeutics; glycomics; glycosylation; glycoengineering; glycobiology; synthesis of glycoconjugates; vaccine development; drug delivery; biomarkers; diagnostics; immunotherapy; regenerative medicine; therapeutic applications

(This special issue belongs to the Section Molecular Pharmacology)

Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition

edited by

De-Guo Han

submission deadline 31 Jul 2026 | Viewed by 4 | Submission Open

Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 1 Aug 2026 | Viewed by 10 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

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