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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Diagnosis and Treatment of Gynaecological Cancers

edited by

Chenhsuan Wu

submission deadline 31 Dec 2025 | Viewed by 3 | Submission Open

Keywords: gynecological oncology; molecular biomarkers; precision medicine; tumor microenvironment; targeted therapy; early detection; immunotherapy; genomic profiling; drug resistance; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Emerging Therapeutic Approaches and Novel Targets in Fibrosis Treatment

edited by

Akrivi Chrysanthopoulou

submission deadline 31 Dec 2025 | Submission Open

Keywords: organ fibrosis; tissue fibrosis; regenerative medicine; fibroblasts; chronic inflammation; immune mechanisms; wound healing; injured epithelium or endothelium; epithelial– mesenchymal transformation; treatment; therapies; therapeutic approaches; diagnosis; prognosis; antifibrotic agents

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 1 Jan 2026 | 2 articles | Viewed by 3271 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine

edited by

Kevin H. Mayo

submission deadline 1 Jan 2026 | Viewed by 86 | Submission Open

Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes

(This special issue belongs to the Section Molecular Biology)

Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification

edited by

Jose Miguel Laffita-Mesa

submission deadline 1 Jan 2026 | Viewed by 11 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; disease stratification; Parkinson’ s disease; Alzheimer’ s disease; spinocerebellar ataxia; precision medicine; digital PCR; circRNA; prognostic biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

From Microbes to Humans: Unveiling the Dynamic World of Carbonic Anhydrases (CAs)

edited by

Clemente Capasso

submission deadline 10 Jan 2026 | Viewed by 489 | Submission Open

Keywords: metalloenzymes; bacteria; pathogens; sulfonamides; inhibitors; activators; anti-infective agents; medicine; anticancer; neurodegenerative diseases; biomedical applications; biotechnology

(This special issue belongs to the Section Biochemistry)

Natural-Derived Bioactive Compounds in Disease Treatment

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Jan 2026 | 4 articles | Viewed by 11027 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7302 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Protein and Protein Interactions

edited by Wu Xu

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4900 | Submission Open

Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics

(This special issue belongs to the Section Molecular Biology)

Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms

edited by

Mariusz Cycoń

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4325 | Submission Open

Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils

(This special issue belongs to the Section Molecular Microbiology)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4239 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

edited by

Miguel Hueso

and

Alfredo Vellido

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3948 | Submission Open

Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning

(This special issue belongs to the Section Molecular Informatics)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3846 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Respiratory Virus Infection

edited by Nikolaos Siafakas

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2451 | Submission Open

Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus

(This special issue belongs to the Section Molecular Microbiology)

Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection

edited by

Vishwanath Venketaraman

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1910 | Submission Open

Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Immunology)

Molecular Breeding and Genetic Regulation of Crops, 2nd Edition

edited by

Chiara Biselli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1076 | Submission Open

Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications

(This special issue belongs to the Section Molecular Plant Sciences)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1068 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Jan 2026 | 1 articles | Viewed by 621 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 20 Jan 2026 | 1 articles | Viewed by 454 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

New Insights into Male Infertility and Sperm Biology

edited by

Monica Muratori

submission deadline 20 Jan 2026 | Viewed by 407 | Submission Open

Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Sarcoma Initiation and Metastasis

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | Viewed by 362 | Submission Open

Keywords: sarcoma; molecular target; metastasis; apoptosis; angiogenesis; microenvironment

(This special issue belongs to the Section Molecular Oncology)

Drug Discovery and Development for Renal Disease Treatment

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | Viewed by 285 | Submission Open

Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Animal Reproduction and Development

edited by

Yu-Feng Wang

submission deadline 20 Jan 2026 | Viewed by 235 | Submission Open

Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer

(This special issue belongs to the Section Molecular Biology)

Advances in Plant Cell Dynamics

edited by

Andrei Smertenko

submission deadline 20 Jan 2026 | Viewed by 200 | Submission Open

Keywords: organelles; cellular polarity; cytoskeleton; vesicle trafficking; cell wall synthesis; signalling; differentiation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 20 Jan 2026 | Viewed by 162 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Bioactive Natural Products and in Human Health

edited by

Eleonora Di Salvo

submission deadline 20 Jan 2026 | Viewed by 85 | Submission Open

Keywords: bioactive compound; human health; functional foods; nutraceutical products; food toxicology; antioxidant properties; anti-inflammation; antimicrobial molecules

(This special issue belongs to the Section Molecular Pharmacology)

Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy (2nd Edition)

edited by

Andrea Ghiroldi

submission deadline 25 Jan 2026 | Viewed by 214 | Submission Open

Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advance in Polymers: Structuralization to Functionalization

edited by Wei Wu

submission deadline 25 Jan 2026 | Viewed by 28 | Submission Open

Keywords: polymer material; molecular weight; chain configuration; polymer chains; chemical groups

(This special issue belongs to the Section Materials Science)

From Mechanisms to Medicine: Cellular Insights into Pulmonary Hypertension

edited by

Swati Dabral

submission deadline 25 Jan 2026 | Viewed by 11 | Submission Open

Keywords: vascular remodeling; cellular mechanisms; hypoxia; growth factors; inflammation

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Targeting Treatments of Respiratory Diseases

edited by

Stefanie Dichtl

submission deadline 26 Jan 2026 | Viewed by 10 | Submission Open

Keywords: respiratory diseases; respiratory infections; COPD; cystic fibrosis; lung tumor; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Materials: Molecular Developments and Applications

edited by Florina Iliescu

submission deadline 27 Jan 2026 | Viewed by 36 | Submission Open

Keywords: antimicrobial; polymers; nanotechnology; nanocomposites; molecular; green systems; POC; prophylaxis

(This special issue belongs to the Section Materials Science)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by Hisham Bahmad

submission deadline 30 Jan 2026 | Viewed by 7 | Submission Open

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

Immunotherapy Versus Immune Modulation of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4636 | Submission Open

Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Drug-Induced Modulation and Immunotherapy of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3649 | Submission Open

Keywords: leukemia; dendritic cells; immunotherapy; immune modulation

(This special issue belongs to the Section Molecular Immunology)

Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition

edited by

Alessandro Fanzani

and

Silvia Codenotti

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3045 | Submission Open

Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies

(This special issue belongs to the Section Molecular Oncology)

New Advances in Bioactive Compounds in Health and Disease

edited by

Luís Silva

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2657 | Submission Open

Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Studies in Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 1 articles | Viewed by 2651 | Submission Open

Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Antibacterial Effect of Nano- and Micro-Materials

edited by

Krasimir Vasilev

and

Vi Khanh Truong

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1566 | Submission Open

Keywords: antibacterial coatings; biomaterials; medical devices; antimicrobial resistance; nanomedicine

(This special issue belongs to the Section Materials Science)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1289 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in the Relationship Between Diabetes and Cancers

edited by

Zsuzsanna Németh

submission deadline 20 Feb 2026 | Viewed by 287 | Submission Open

Keywords: diabetes; insulin resistance; glucose intolerance; glucolipotoxicity; ER stress; oxidative stress; cancer development

(This special issue belongs to the Section Molecular Oncology)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 20 Feb 2026 | Viewed by 197 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Genetics in Rare Diseases: A Genomic Odyssey

edited by

Klaus Brusgaard

submission deadline 20 Feb 2026 | Viewed by 179 | Submission Open

Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance

edited by

Ivayla Pantcheva

submission deadline 20 Feb 2026 | Viewed by 140 | Submission Open

Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Drug Discovery Based on Natural Products

edited by Woo-kyung Kim

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5224 | Submission Open

Keywords: drug discovery; bioactive compounds; pharmacological activities and mechanisms; omics technologies

(This special issue belongs to the Section Molecular Pharmacology)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1073 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormones: Evolutionary and Functional Role

edited by

Giulia Guerriero

submission deadline 20 Mar 2026 | 1 articles | Viewed by 948 | Submission Open

Keywords: hormone action; brain organization; sexual behavior; endocrine tissue; receptor neuroexpression; endocrine control; endocrine disruption; climate change and reproduction; hormones and evolution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Enzyme Inhibitors: Mechanisms, Applications, and Future Perspectives

edited by

Clemente Capasso

and

Valeria Pittalà

submission deadline 30 Mar 2026 | 4 articles | Viewed by 3886 | Submission Open

Keywords: enzyme inhibitors; drug design; drug discovery; drug therapy; resistance mechanisms; cancer; drug delivery systems; biocatalysts; enzymes in industrial applications

(This special issue belongs to the Section Biochemistry)

Research Progress of Orthopedic Materials

edited by Robert Karpiński

submission deadline 20 Apr 2026 | Viewed by 245 | Submission Open

Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings

(This special issue belongs to the Section Materials Science)

Fascial Anatomy and Histology: Advances in Molecular Biology

edited by

Carla Stecco

submission deadline 20 May 2026 | 3 articles | Viewed by 5957 | Submission Open

Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 3501-3550 on page 71 of 71.

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