Molecular Mechanisms in Cardiovascular Disease Progression
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 140
Special Issue Editor
Interests: cardiac physiology; cardiomyopathy; muscle mechanics; diastolic heart failures; mitochondrial biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases (CVDs) remain the foremost cause of global mortality and are characterized by progressive pathophysiological remodeling that ultimately impairs cardiac structure and function. A defining feature of CVD is its chronic and progressive course, in which pathological changes—such as cardiomyopathy, myocardial fibrosis, microvascular and endothelial dysfunction, inflammation, and bioenergetic impairment—gradually advance from early stages to overt disease if left unaddressed. Elucidating the molecular mechanisms that drive this progression is critical for identifying novel therapeutic targets and developing more effective interventions.
The primary objective of this Special Issue, Molecular Mechanisms in Cardiovascular Disease Progression, is to invite original research and review articles that investigate the molecular basis of CVD across major pathological entities, including ischemic heart disease, cardiomyopathies (hypertrophic and dilated), heart failure with preserved or reduced ejection fraction (HFpEF/HFrEF), and vascular disorders such as atherosclerosis and endothelial dysfunction. Submissions focused on signal transduction, transcriptional and epigenetic regulation, oxidative stress, inflammation, mitochondrial dysfunction, and sarcomeric remodeling are particularly encouraged.
We look forward to your contributions and to curating an insightful and timely collection that advances our understanding of cardiovascular disease progression at the molecular level.
Dr. Ying-Hsi Lin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- cardiovascular disease progression
- molecular mechanisms
- inflammation
- signal transduction
- transcriptional and epigenetic regulation
- mitochondrial dysfunction
- sarcomeric remodeling
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