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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Insights into Reproductive Toxicology

edited by Maria Cristina Budani

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2818 | Submission Open

Keywords: endocrine disruptors; environmental toxicants; fertility; heavy metals; lifestyle habits; molecular mechanisms; pregnancy; teratology; teratogenic compounds; reproductive toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Pharmacology and Interventions in Cardiovascular Disease: 2nd Edition

edited by

Magdalena Zabielska-Kaczorowska

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2769 | Submission Open

Keywords: cardiovascular pharmacology; cardiovascular interventions; cardioprotection; myocardial ischemia and infarction; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Metabolism in Human Health and Disease

edited by

Abdelnaby Khalyfa

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2674 | Submission Open

Keywords: molecular metabolism; metabolic pathways; insulin resistance; Warburg effect; chronic disease; metabolomics; precision medicine; metabolic dysfunction; cancer metabolism; personalized nutrition; enzyme-targeted therapy; systems biology; cellular energy; metabolic health; preventative healthcare

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Biomechanics of Cardiovascular Remodeling

edited by

Kevin Willy

and Maximilian Doldi Philipp

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2667 | Submission Open

Keywords: cardiovascular remodeling; cardiac imaging; cardiovascular intervention; cardiovascular pathways; cardiovascular research; structural heart disease; cellular signaling

(This special issue belongs to the Section Molecular Biophysics)

Recent Research of Protein Structure Prediction and Design

edited by

Alexandre G. De Brevern

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2656 | Submission Open

Keywords: protein design; multidomain proteins; AlphaFold2; protein folding; deep learning

(This special issue belongs to the Section Biochemistry)

Microbial Genomics in the Omics Era

edited by

Surajit De Mandal

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2626 | Submission Open

Keywords: microbe; bioinformatics; DNA; RNA; protein; sequencing; structure; omics

(This special issue belongs to the Section Molecular Microbiology)

Innovative Approaches to Enhancing Bioavailability and Bioaccessibility of Bioactive Compounds from Plant and Food Extracts

edited by

Ana-Maria Vlase

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2620 | Submission Open

Keywords: bioactive compounds; nutraceuticals; functional foods; in vitro and in vivo models; bioavailability; bioaccessibility; nanotechnology; delivery systems; molecular mechanisms; proteomics; genomics; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Bioactive Compounds in Human Health

edited by

Dorota Gumul

submission deadline 20 Mar 2026 | 3 articles | Viewed by 2614 | Submission Open

Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in the Field of Thrombosis and Hemostasis

edited by

Claudia Maria Radu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2554 | Submission Open

Keywords: bleeding; thrombosis; new diagnostic tests; rare diseases; platelet function; biomarkers; risk factors; thrombocytopenia; endothelial dysfunction; autoantibodies; extracellular vesicles; stem cells; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drugs Targeting Cancer Signaling Pathways: Dissecting Mechanisms to Unlock New Therapeutic Targets

edited by Souleymane Abdoul-Azize

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2539 | Submission Open

Keywords: small-molecule drugs; signal transduction; therapeutic targets; therapeutic resistance; oncogenic signaling; novel biomarkers; cancer therapy; cancer signaling pathways; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Relationship Between Plant Microbiome and Immunity

edited by

Sergio Molinari

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2507 | Submission Open

Keywords: microbiome; plant immune system; rhizosphere of plant roots; microbe-associated molecular patterns (MAMPs)

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Mitochondrial Neurodegenerative Diseases

edited by

Matteo Calcagnile

and Paola Pontieri

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2476 | Submission Open

Keywords: mitochondrial disease; nuclear genome; mitochondrial genome; human MRP genes; MRPL44; NAM9; GEP3; Alzheimer’ s disease; Parkinson’ s disease; yeast and C. elegans model organisms

(This special issue belongs to the Section Molecular Neurobiology)

3D Technology in Biomedicine: Studying Molecular Mechanisms in Health and Disease

edited by Flavia Carton

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2453 | Submission Open

Keywords: 3D technologies; biomedicine; molecular biology; in vitro/ex vivo models; regenerative medicine; human diseases

(This special issue belongs to the Section Materials Science)

Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health

edited by

Rosa Maria Paragliola

and Andrea Corsello

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2400 | Submission Open

Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome

(This special issue belongs to the Section Molecular Biology)

The Role and Mechanisms of Natural Products in Inflammatory Responses and Inflammatory Diseases

edited by

Young-Su Yi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2331 | Submission Open

Keywords: natural product; bioactive component; inflammation; inflammatory disease; anti-inflammatory; mechanism

(This special issue belongs to the Section Molecular Immunology)

Targeting MAPK in Human Diseases

edited by

Elisabetta Rovida

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2307 | Submission Open

Keywords: ERK; DUSP; cancer; inflammation; neurodegenerative diseases; autoimmune diseases; targeted therapy; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Organic Compounds in Photodynamic Therapy: Synthesis, Mechanism of Action and Biological Potential

edited by

Maria G. P. M. S. Neves

Nuno M. M. Moura

and

Catarina I. V. Ramos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2284 | Submission Open

Keywords: organic photosensitizers; photodynamic therapy; synthetic strategies; mechanism of action; cancer cells; microorganisms

(This special issue belongs to the Section Biochemistry)

Mechanism of Cellular Signaling, Dysfunction, and Drug Effects on Alzheimer's Disease

edited by

Eva Kiss

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2247 | Submission Open

Keywords: AD; targeted therapy; Alzheimer's disease; neurodegenerative disease; tau protein

(This special issue belongs to the Section Molecular Neurobiology)

Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis

edited by

Younseong Song

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2203 | Submission Open

Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology

(This special issue belongs to the Section Molecular Biology)

The Role of Lipids in Human Health

edited by

Angela Maria Rizzo

and Irma Colombo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2142 | Submission Open

Keywords: lipids; lipidomics; fatty acids; sphingolipids; steroids; metabolism

(This special issue belongs to the Section Biochemistry)

The Role of Macrophages in Tumors

edited by

Julia Kzhyshkowska

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2103 | Submission Open

Keywords: tumor-associated macrophages; transcriptome; metabolome; epigenetics; angiogenesis; metastasis; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health

edited by

Margarida Lorigo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2062 | Submission Open

Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health

(This special issue belongs to the Section Molecular Toxicology)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1904 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Bioactive Molecules from Food Waste in Food Packaging Applications

edited by

Jennifer Gubitosa

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1897 | Submission Open

Keywords: wastes upcycling; waste management; circular economy; green chemistry; bioactive molecules; agri-food wastes and by-products; food packaging; active packaging

(This special issue belongs to the Section Materials Science)

Metabolic Regulators of Bone Health

edited by

Akkouch Adil

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1869 | Submission Open

Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bioconjugates and Application

edited by

Gábor Mező

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1865 | Submission Open

Keywords: bioconjugates; targeted therapy; homing moieties; drug delivery; bioconjugates as diagnostic tools; targeted nanoparticles; antibody– drug conjugates; linkage systems

(This special issue belongs to the Section Macromolecules)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1853 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

New Insights into Epilepsy: From Molecular Physiology to Pathology

edited by Paolo Mainardi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1838 | Submission Open

Keywords: epilepsy; molecular pathology; disease; therapeutic strategies; celluar advance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Nanoparticle Composites: Functionalization and Application

edited by

Jovan M. Nedeljković

and

Vesna Lazić

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1835 | Submission Open

Keywords: nanoparticles; nanocomposites; synthesis; functionalization; interface; photocatalysis; antimicrobial nanoparticles; nanomedicine; theoretical modelling; computer simulations

(This special issue belongs to the Section Molecular Nanoscience)

Bioactive Phenolics and Polyphenols 2025

edited by

Davide Barreca

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1832 | Submission Open

Keywords: phenolic metabolism; biological activities; stability to food processing; elicitation; methods of analysis; dietary supplements; nutraceutical ingredients; non-thermal processing; extraction and purification

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Nanomedicines Against Bacterial Infections

edited by

Stephanie Andrade

, Nuno Guimarães,

Maria João Ramalho

and

Joana A. Loureiro

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1809 | Submission Open

Keywords: nanotechnology; nanoparticle; nanocarriers; nanoantibiotic; drug delivery system; targeted delivery; theranostic; infectious diseases; antibacterial agent; antimicrobial resistance; biomedical application

(This special issue belongs to the Section Molecular Nanoscience)

Vitamin D Signaling in Human Health and Diseases

edited by

Daniela Rovito

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1775 | Submission Open

Keywords: vitamin D receptor; vitamin D; prevention; therapeutic potential; mineral homeostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Targeted Therapies in Ischemic Stroke

edited by Alicia Aliena-Valero and María Castelló-Ruiz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1753 | Submission Open

Keywords: ischemic stroke; cerebral protection; repair treatments; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research of Kidney Diseases

edited by Andrea Angioi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1752 | Submission Open

Keywords: molecular genetics; kidney disease; biomarkers; cellular signaling; target therapeutics; innovative treatments

(This special issue belongs to the Section Molecular Biology)

Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry

edited by Łukasz Huminiecki

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1695 | Submission Open

Keywords: multi-omics; statistics; gene expression analysis

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights into Transplantation and Machine Perfusion

edited by

Joan Roselló-Catafau

and

Arnau Panisello-Roselló

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1689 | Submission Open

Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1676 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Cotton Molecular Genomics and Genetics (Third Edition)

edited by

Jie Sun

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1655 | Submission Open

Keywords: cotton; biotic or abiotic stress; disease resistance; fiber yield and quality; gene editing; gene identification and function validation; genome-wide association study; QTL identification

(This special issue belongs to the Section Molecular Plant Sciences)

Green Chemical Pesticide Design, Synthesis and Evaluation

edited by Ranfeng Sun

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1647 | Submission Open

Keywords: green pesticides; natural products; action mechanism of pesticides; synthesis

(This special issue belongs to the Section Biochemistry)

Bee Products and Their Flavonoids: Recent Advances in Molecular Mechanisms, Therapeutic Applications, and Innovative Delivery Systems

edited by

Nada Orsolic

and

Maja Jazvinšćak Jembrek

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1601 | Submission Open

Keywords: honeybee products; flavonoids; bioactive compounds; biological activity; pharmacological activity; health benefits; side effects; disease prevention; antioxidant activity; apitherapy; nutritional properties; innovative technical approaches

(This special issue belongs to the Section Molecular Biology)

Solanaceae Biology: From Genetics to Metabolism

edited by

Pengxiang Fan

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1567 | Submission Open

Keywords: Solanaceae; nightshade family; tomato; potato; tobacco; eggplant; genetics; metabolism; crop improvement; specialized metabolite

(This special issue belongs to the Section Molecular Plant Sciences)

Focus on the Tryptophan Pathway

edited by

Burkhard Poeggeler

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1550 | Submission Open

Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan

(This special issue belongs to the Section Molecular Biology)

Nanostructures: From Synthesis, Modification to Biomedical Applications

edited by Kleoniki Giannousi and

Catherine Dendrinou-Samara

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1517 | Submission Open

Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors

(This special issue belongs to the Section Molecular Nanoscience)

Gene Mutations in Cancer

edited by

Lucie Benešová

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1502 | Submission Open

Keywords: oncogenetics; somatic mutations; intratumor mutational heterogeneity; tumor mutational burden; circulating tumor DNA; liquid biopsy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Inflammatory Bowel Disease: Molecular Insights—2nd Edition

edited by

Belal Chami

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1463 | Submission Open

Keywords: genomic sequencing; microbiome; dysbiosis; commensal flora; omics; immunobiology; colitis; Crohn’ s disease; ulcerative colitis; multiomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Microbial Natural Products

edited by Wenli Li

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1382 | Submission Open

Keywords: microbial natural products; biosynthetic gene clusters; structural elucidation; metabolic engineering; synthetic biology; bioactivity profiling; sustainable biomanufacturing

(This special issue belongs to the Section Molecular Microbiology)

Biological Barriers: Consciousness and Mental Illness

edited by

Adonis Sfera

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1334 | Submission Open

Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases

(This special issue belongs to the Section Molecular Biology)

Genetics and Omics in Autoimmune Diseases

edited by

Julian Ramírez-Bello

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1326 | Submission Open

Keywords: autoimmune diseases; genetics; genomics; omics; single-nucleotide variants; copy number variants; variation; susceptibility; mRNAs; microRNAs; long non-coding RNAs; masive sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Studies of Hematologic Malignancies

edited by

Myunggon Ko

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1266 | Submission Open

Keywords: hematologic malignancies; molecular mechanisms; genetic and epigenetic aberrations; molecular diagnosis; targeted therapy and biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease

edited by

Ju-Tae Sohn

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1246 | Submission Open

Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1201-1250 on page 25 of 63.

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