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Advanced Molecular Research on Pregnancy Complication Mechanisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 158

Special Issue Editor


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Guest Editor
Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia
Interests: obstetrics; gynecology; medicine

Special Issue Information

Dear Colleagues,

Despite significant progress in improving maternal health during pregnancy, every pregnancy still represents a health risk. The etiology and pathogenesis of the most common pregnancy complications, including hypertensive disorders of pregnancy, gestational diabetes, and intrauterine growth restriction, remain completely unresolved, making it difficult to have reliable biomarkers and adequate risk assessment, prevention, and therapy.

This Special Issue, titled "Advanced Molecular Research on Pregnancy Complication Mechanisms", aims to study complex underlying molecular mechanisms, related to disorders of maternal metabolism, involved in the development of the most common pregnancy complications.

The goal of this Special Issue is to promote a comprehensive approach to research in this field. Our intention is to present original research papers and reviews that offer insights into the molecular mechanisms that underlie signaling pathways, unfavorable biochemical microenvironments, genetic and epigenetic mechanisms, and immunological challenges around pregnancy complication development. Understanding these molecular mechanisms helps to identify potential targets for better risk assessment, prevention, and therapeutic interventions and improve pregnancy outcomes for both mothers and children.

Dr. Aleksandra Stefanović
Guest Editor

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Keywords

  • hypertensive pregnancy disorders
  • gestational diabetes
  • intrauterine growth restriction
  • maternal metabolism in pregnancy complications
  • genetic and epigenetic mechanisms in pregnancy complications
  • immunology in pregnancy complications

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Published Papers (1 paper)

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Research

14 pages, 1849 KB  
Article
Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus
by Renata Saucedo, Erika Magallón-Gayón, Rocio Alejandra Chavez-Santoscoy, Mary Flor Díaz-Velázquez, Aldo Ferreira-Hermosillo, Diana Ojeda-López, Wendy Porras-Marcial, Debbie López-Sánchez and Jorge Valencia-Ortega
Int. J. Mol. Sci. 2025, 26(19), 9595; https://doi.org/10.3390/ijms26199595 - 1 Oct 2025
Abstract
Placenta and visceral adipose tissue (VAT) are implicated in the development of gestational diabetes mellitus (GDM). In the present study, we examined the whole-transcriptomic profile of both tissues in GDM women to elucidate the molecular basis of GDM pathogenesis. The whole-transcriptome profile was [...] Read more.
Placenta and visceral adipose tissue (VAT) are implicated in the development of gestational diabetes mellitus (GDM). In the present study, we examined the whole-transcriptomic profile of both tissues in GDM women to elucidate the molecular basis of GDM pathogenesis. The whole-transcriptome profile was analyzed in placenta and VAT from at-term patients with GDM and controls using RNA-seq. qPCR was used to validate several differentially expressed genes (DEGs). A total of 179 DEGs were observed in the placenta and 4 in VAT, including both up- and downregulated genes. The expression of the selected mRNAs for validation was consistent with the sequencing results. An analysis of the placental upregulated DEGs in the GDM women showed enrichment in functions including the G-protein-coupled receptor signaling pathway, organophosphate biosynthetic process, and phospholipid metabolic process, while the downregulated DEGs were enriched in cell motility and the cell migration process. The target pathways of DEGs in VAT are related to cancer and to the activation of the complement cascade. Molecular pathways involved in G-protein-coupled receptor signaling, the organophosphate biosynthetic process, the phospholipid metabolic process, and cell motility and cell migration are altered in the placentas of GDM women. Moreover, a disordered complement cascade might take place in the VAT of GDM women. Full article
(This article belongs to the Special Issue Advanced Molecular Research on Pregnancy Complication Mechanisms)
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