ijms-logo

Journal Browser

Journal Browser

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 March 2026) | Viewed by 1893

Special Issue Editor


E-Mail Website
Guest Editor
Unit of Synergetic Studies for Space, Kyoto University, Kyoto 606-8501, Japan
Interests: space medicine; space life sciences; physiology; cell biology; pharmacology; exercise; countermeasure; artificial gravity; space education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is anticipated that more humans will spend time in space in the future, and that the duration of stay will become longer. For this reason, the field of space medicine, which studies how the space environment affects the human body in the long term, is becoming even more important.

This Special Issue focuses on research on the effects of the space environment on living organisms. Space medical research includes not only space experiments but also analog experiments that simulate the space environment. Therefore, this Special Issue covers a wide range of research examining physiological mechanisms and gene expression in organisms and living beings both during space stays and through ground-based research. We welcome you to submit research on these topics.

Dr. Masahiro Terada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microgravity
  • space radiation
  • closed environment
  • space flight
  • parabolic flight
  • clinostat
  • human
  • rodent
  • microorganism
  • countermeasure
  • artificial gravity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:
36 pages, 6557 KB  
Review
New Knowledge About Tissue Engineering Under Microgravity Conditions in Space and on Earth
by Markus Wehland, Thomas J. Corydon, Luis Fernando González-Torres, Fatima Abdelfattah, Jayashree Sahana, Herbert Schulz, Ashwini Mushunuri, Hanna Burenkova, Simon L. Wuest, Marcus Krüger, Armin Kraus and Daniela Grimm
Int. J. Mol. Sci. 2026, 27(1), 341; https://doi.org/10.3390/ijms27010341 - 28 Dec 2025
Viewed by 1352
Abstract
Microgravity (µg)-generated three-dimensional (3D) multicellular aggregates can serve as models of tissue and disease development. They are relevant in the fields of cancer and in vitro metastasis or regenerative medicine (tissue engineering). Driven by the 3R concept—replacement, reduction, and refinement of [...] Read more.
Microgravity (µg)-generated three-dimensional (3D) multicellular aggregates can serve as models of tissue and disease development. They are relevant in the fields of cancer and in vitro metastasis or regenerative medicine (tissue engineering). Driven by the 3R concept—replacement, reduction, and refinement of animal testing—µg-exposure of human cells represents a new alternative method that avoids animal experiments entirely. New Approach Methodologies (NAMs) are used in biomedical research, pharmacology, toxicology, cancer research, radiotherapy, and translational regenerative medicine. Various types of human cells grow as 3D spheroids or organoids when exposed to µg-conditions provided by µg simulating instruments on Earth. Examples for such µg-simulators are the Rotating Wall Vessel, the Random Positioning Machine, and the 2D or 3D clinostat. This review summarizes the most recent literature focusing on µg-engineered tissues. We are discussing all reports examining different tumor cell types from breast, lung, thyroid, prostate, and gastrointestinal cancers. Moreover, we are focusing on µg-generated spheroids and organoids derived from healthy cells like chondrocytes, stem cells, bone cells, endothelial cells, and cardiovascular cells. The obtained data from NAMs and µg-experiments clearly imply that they can support translational medicine on Earth. Full article
Show Figures

Figure 1

Back to TopTop