The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 April 2026) | Viewed by 2749
Special Issue Editor
Interests: exosome; inflammation; natural extract
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is supervised by Prof. Dr. Mi Young Lee with the assistance of our Topical Advisory Panel Member Dr. Ji-Hye Kang (Soonchunhyang University).
Recently, DNA-derived substances, including PDRN (Polydeoxyribonucleotide) and PN (Polynucleotide), have gained significant attention for their cosmetic and therapeutic effects. PDRN is typically extracted from salmon sperm DNA, and the key functions of PDRN include tissue regeneration, wound healing, and anti-inflammatory effects. Likewise, PN, which is primarily sourced from fish germ cells, has been reported to enhance tissue regeneration. Although PDRN is predominantly recognized for its animal-derived forms, research is increasingly exploring plant-based alternatives.
In this Special Issue, we aim to summarize and expand the understanding of the beneficial functions of DNA-derived substances in inflammation, aging, and associated symptoms. Additionally, we welcome innovative approaches that improve the stability, delivery, and efficacy of PDRN for inclusion in this Special Issue. Furthermore, DNA-derived substances, often referred to as nucleic acid-based therapeutics, encompass a variety of treatments that utilize DNA or RNA segments for therapeutic purposes. Therefore, studies involving antisense oligonucleotides, RNA interference (RNAi), and nucleotide analogues are highly encouraged, as these areas have not yet been fully explored.
Prof. Dr. Mi Young Lee
Guest Editor
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Keywords
- PDRN
- PN
- DNA-derived substances
- nucleic acid-based therapeutics
- inflammation
- aging
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