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Natural Active Substances in Human Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 507

Special Issue Editor

Special Issue Information

Dear Colleagues,

Natural active substances derived from plants, fungi, and marine life have long been utilized in traditional medicine. In recent years, scientific interest has increasingly focused on elucidating their molecular mechanisms of action in human disease treatment. These bioactive compounds exert diverse pharmacological effects, including anti-inflammatory, anti-obesity, anti-diabetic, and neuroprotective activities, primarily through the modulation of key molecular signaling pathways. Recent biomedical research has progressively unveiled their roles in oxidative stress regulation, lipid metabolism, glucose homeostasis, immune modulation, and inflammatory signaling, providing new insights into their therapeutic potential.

This Special Issue aims to explore the molecular and cellular mechanisms through which natural active substances contribute to disease prevention and treatment. We welcome original research and review articles that investigate specific molecular pathways regulated by natural compounds and their therapeutic roles. We look forward to the active participation of researchers in this field and hope to facilitate the sharing of innovative findings.

Prof. Dr. Hyeung-Jin Jang
Guest Editor

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Keywords

  • natural active substances
  • bioactive compounds
  • molecular mechanisms
  • traditional medicine
  • metabolic disorders
  • inflammatory diseases
  • neurodegenerative diseases

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Published Papers (1 paper)

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Research

16 pages, 5717 KiB  
Article
Circaea mollis Siebold & Zucc. Induces Apoptosis in Colorectal Cancer Cells by Inhibiting c-Myc Through the Mediation of RPL5
by So-Mi Park, Nanyeong Kim, Ye-Rin Park, Seok Woo Kim, Ji Hoon Jung, Yun-Cheol Na, Daeho Kwon, Hyungsuk Kim and Hyeung-Jin Jang
Int. J. Mol. Sci. 2025, 26(10), 4664; https://doi.org/10.3390/ijms26104664 - 13 May 2025
Viewed by 415
Abstract
Colorectal cancer remains a significant global health concern. In this study, we investigated the anticancer potential of Circaea mollis Siebold & Zucc. (CS&Z), a traditional medicinal plant known for its anti-inflammatory, anti-arthritic, and antioxidant properties, in the treatment of colorectal cancer. We found [...] Read more.
Colorectal cancer remains a significant global health concern. In this study, we investigated the anticancer potential of Circaea mollis Siebold & Zucc. (CS&Z), a traditional medicinal plant known for its anti-inflammatory, anti-arthritic, and antioxidant properties, in the treatment of colorectal cancer. We found that CS&Z induces apoptosis and G1/S phase cell cycle arrest in colorectal cancer cells, primarily through the suppression of the proto-oncogene c-Myc. Specifically, the depletion of RPL5, a ribosomal protein associated with c-Myc regulation, reversed the suppression of c-Myc by CS&Z. Additionally, when co-administered with the standard chemotherapeutic agents doxorubicin and 5-fluorouracil, CS&Z demonstrated synergistic effects, thereby further emphasizing its potential efficacy as a therapeutic option for the treatment of colorectal cancer. Moreover, the constituents of CS&Z, detected through liquid chromatography–mass spectrometry analysis, reportedly exhibit anticancer activities. Taken together, our findings suggest that CS&Z holds promise as a natural product capable of modulating oncogenic signaling in colorectal cancer and may serve as a complementary agent in future therapeutic strategies. Full article
(This article belongs to the Special Issue Natural Active Substances in Human Diseases)
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