Cellular and Molecular Mechanisms in Inflammatory Bowel Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 104
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inflammatory Bowel Disease (IBD) represents a significant and growing global health challenge. Despite decades of research, the precise etiopathogenesis of IBD remains incompletely understood, and there is currently no cure. Recent advances underscore the multifactorial nature of IBD, implicating a complex interplay among genetic susceptibility (over 200 risk loci have been identified), the dysregulation of the mucosal immune response, alterations in the gut microbiome, and diverse environmental and lifestyle factors. Systems biology and multi-omics approaches have revealed distinct molecular and cellular mechanisms underpinning IBD pathogenesis, including aberrant cytokine signaling, epithelial barrier dysfunction, and the dysbiosis of intestinal microbiota. Notably, transcriptomic and metatranscriptomic meta-analyses have identified robust pro-inflammatory signatures and disrupted epithelial and angiogenic pathways in IBD-affected tissues, providing novel insights into disease mechanisms and potential therapeutic targets.
This Special Issue seeks to advance our understanding of the cellular and molecular mechanisms driving IBD onset, progression, and complications. We particularly encourage submissions that leverage cutting-edge methodologies—such as integrated multi-omics, advanced imaging, and computational modeling—to elucidate disease mechanisms and identify novel therapeutic targets. While we prioritize human studies, we also welcome high-quality research utilizing animal models and in vitro systems, provided that the findings are translatable to human disease.
Dr. Michael Bording-Jorgensen
Guest Editor
Manuscript Submission Information
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Keywords
- IBD
- cytokines
- microbiome
- Crohn’s disease
- ulcerative colitis
- dysbiosis
- mucosal immunity
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