Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 3rd Edition

Dear Colleagues,

Redox homeostasis plays a fundamental role in maintaining the integrity of human metabolism by ensuring proper cellular signaling, defense, and adaptation to physiological and environmental challenges. Reactive oxygen and nitrogen species (ROS and RNS) act not only as potentially harmful oxidants but also as crucial signaling mediators that regulate gene expression, enzyme activity, and metabolic communication. When the delicate redox balance is disturbed, oxidative stress arises, contributing to the onset and progression of a wide range of human diseases, including metabolic, cardiovascular, neurodegenerative, inflammatory, and neoplastic disorders.

This Special Issue aims to provide an open platform for the dissemination of high-quality research exploring molecular and biochemical mechanisms underlying redox regulation and oxidative stress in human physiology and pathology.

We warmly invite the submission of original research articles and comprehensive review papers addressing various aspects of redox biology, oxidative stress, and their relevance to human health and disease. Contributions dealing with redox signaling pathways, mitochondrial and endoplasmic reticulum crosstalk, oxidative stress biomarkers, and antioxidant or redox-modulating therapeutic approaches are particularly welcome.

Suggested topics include, but are not limited to, the following:

• Molecular mechanisms of redox homeostasis and oxidative stress;
• Crosstalk between redox balance, metabolism, and inflammation;
• ROS/RNS signaling and mitochondrial dysfunction in human diseases;
• Oxidative stress in metabolic, neurodegenerative, and neoplastic disorders;
• Biomarkers and experimental models of oxidative stress;
• Antioxidant defense mechanisms and pharmacological modulation;
• Translational and clinical studies on redox-targeted therapies.

We look forward to receiving your valuable contributions to this Special Issue.

Dr. Jarosław Nuszkiewicz
Prof. Dr. Alina Woźniak
Guest Editors

Manuscript Submission Information

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