Advances in Next-Generation CRISPR and Gene Editing Tools
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 32
Special Issue Editor
Special Issue Information
Dear Colleagues,
Precision medicine and biotechnology have reached a turning point with the development of next-generation CRISPR and gene editing technologies. Fundamental limitations in natural gene editing systems have been overcome by recent developments in artificial intelligence-driven CRISPR protein design, smaller CRISPR proteins, and improved precision editing tools. While developments in prime editing, base editing, and epigenome editing are expanding therapeutic options, the understanding and ability to use these state-of-the-art technologies will facilitate converting these lab findings into clinical applications to treat genetic diseases, cancer, and other human conditions.
Topics of interest include, but are not limited to, the following:
-AI-designed CRISPR proteins and their experimental validation;
-Next-generation precision editing systems (prime editing, base editing);
-Miniaturized CRISPR platforms for improved delivery;
-Advanced delivery technologies for gene editing and in vivo applications;
-CRISPR-based epigenome editing and therapeutic applications;
-Single-cell CRISPR screening methodologies.
Authors are invited to contribute basic research and review articles on advancing next-generation gene editing technologies to enhance research capabilities and therapeutic applications.
Dr. Oscar Pérez-Leal
Guest Editor
Manuscript Submission Information
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Keywords
- CRISPR engineering
- miniaturized CRISPR
- gene editing delivery
- prime editing
- base editing
- epigenome editing
- single-cell CRISPR
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