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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Research in Membrane Transporters, Channels, and Receptors

edited by

Ivana Vrhovac Madunic

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5145 | Submission Open

Keywords: membrane transporters; cell membrane; transmembrane proteins; glucose transport; ion channels; cellular receptors; signal tranduction; pathophysiology; diabetes; aging

(This special issue belongs to the Section Molecular Biology)

Exploring Rare Diseases: Genetic, Genomic and Metabolomic Advances: 2nd Edition

edited by

Judit Bene

and

Kinga Hadzsiev

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5066 | Submission Open

Keywords: rare diseases; genotype–phenotype analyses; NGS; mass spectrometry; biomarker discovery; molecular targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models

edited by Eugenio Alladio and

Elena Pilli

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4942 | Submission Open

Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic and Post-Transcriptional Regulation of Gene Expression

edited by

Lidia Borkiewicz

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4912 | Submission Open

Keywords: epigenome; DNA methylation; chromatin remodeling; histone modifications; non-coding RNA; epitranscriptome; alternative splicing; RNA methylation; RNA edition

(This special issue belongs to the Section Molecular Biology)

Advances in the Purinergic System

edited by

Margarete Dulce Bagatini

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4734 | Submission Open

Keywords: purinergic system; receptors; ectonucleotidases; CD39; CD73; purinergic signaling

(This special issue belongs to the Section Biochemistry)

Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides

edited by

Natalia Nowacka-Jechalke

and

Marta Kinga Lemieszek

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4701 | Submission Open

Keywords: natural polysaccharides; phytochemicals; nutraceuticals; structure–activity relationship; anticancer potential; immunomodulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Circulating Biomarkers for the Diagnosis of Cancer

edited by Fernando Luiz Affonso Fonseca

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4618 | Submission Open

Keywords: biomarkers; circulating ; lab methods; diagnosis; screening

(This special issue belongs to the Section Molecular Oncology)

G Protein-Coupled Receptor Signaling and Regulation, 2nd Edition

edited by

Vsevolod V. Gurevich

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4595 | Submission Open

Keywords: GPCRs; signaling; trafficking; G proteins; arrestins; RGS proteins; GRKs

(This special issue belongs to the Section Biochemistry)

Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition

edited by Sanja Dabelić

submission deadline 30 Nov 2026 | 4 articles | Viewed by 4591 | Submission Open

Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics

(This special issue belongs to the Section Macromolecules)

New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms

edited by

Laura Georgiana Necula

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4575 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostic; targeted therapy; biomarkers; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4555 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Pathology and Next-Generation Biomarkers in Nephrology

edited by

Marijn Speeckaert

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4500 | Submission Open

Keywords: nephrology; genetic mutations; epigenetics; next-generation biomarkers; proteomics; metabolomics; single-cell sequencing; spatial transcriptomics; liquid biopsy; cfDNA; exosomes; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bridging Molecules and Reactions: Next-Generation Approaches for Advancing Electrocatalytic Efficiency

edited by

Abu Talha Aqueel Ahmed

submission deadline 30 Nov 2026 | 1 articles | Viewed by 4500 | Submission Open

Keywords: electrochemical nanomaterials; energy storage and conversion; electrocatalysis and reaction mechanisms; photoelectrochemical water splitting; electrochemical energy storage devices; nanocomposites and functionalized materials; molecular-level electrocatalysis; electrocatalyst and photocatalysts; in-situ spectroscopy and atomistic modeling; hybrid molecular–nanostructured systems; sustainable and natural resource–derived materials; DFT related to reaction kinetics; AOP

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

From Biology to Biomechanics: Molecular Advances in Orthodontic Remodeling and Acceleration

edited by

Marcin Derwich

and

Alessandra Lucchese

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4493 | Submission Open

Keywords: orthodontic tooth movement; bone remodeling; root resorption; molecular mechanisms; inflammatory response; corticotomy-assisted orthodontics; biomechanics; periodontal ligament; cellular signaling; accelerated orthodontic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Biology of Cardiac Hypertrophy and Heart Failure: Pathogenesis, Diagnostics and Treatment—2nd Edition

edited by

Morris Karmazyn

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4462 | Submission Open

Keywords: cardiac hypertrophy; myocardial remodelling; heart failure; cellular mechanisms; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Crop Quality

edited by

Jinsong Bao

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4147 | Submission Open

Keywords: crop quality; molecular breeding; multi-omics; gene editing; precision agriculture; functional genomics; rice; wheat; maize; barley; sorghum; millet; potato; cotton; molecular markers; genome-wide association studies; genome editing; genome selection; molecular selection; transcriptomics; omics; post-translational regulation; starch; protein; lipids; vitamin; processing quality; eating quality

(This special issue belongs to the Section Molecular Plant Sciences)

Hemolytic Anemia: From Molecular Mechanisms to Therapeutic Exploitation

edited by Joan-Lluis Vives-Corrons

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4067 | Submission Open

Keywords: hemolytic anemias; red blood cells; sickle cell disease; targeted therapies; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Ataxia

edited by

Jose Miguel Laffita-Mesa

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4057 | Submission Open

Keywords: ataxia; molecular mechanisms; repeat expansion disorders; gene discovery; biomarkers; RNA biology; protein aggregation; epigenetics; gene therapy; neurodegeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 30 Nov 2026 | 1 articles | Viewed by 3917 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene–environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Germplasm Innovation Technology in Aquatic Genetic Breeding

edited by

Hui Qiao

submission deadline 30 Nov 2026 | 4 articles | Viewed by 3914 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Viral Vector-Mediated Genome Editing Therapy

edited by

Izumu Saito

submission deadline 30 Nov 2026 | 1 articles | Viewed by 3880 | Submission Open

Keywords: CRISPR; genome editing; base editing; AAV vector; adenovirus vector; lentivirus vector; viral vectors; inherited disease; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomic, Transcriptomic, and Epigenetic Approaches in Fish Research

edited by

Feng Liu

submission deadline 30 Nov 2026 | 5 articles | Viewed by 3860 | Submission Open

Keywords: fish biology; omics technologies; genomics and transcriptomics; environmental adaptation; aquaculture traits

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence, Multi-Omics, and Molecular Modelling in Modern Drug Discovery

edited by

Shaban Ahmad

submission deadline 30 Nov 2026 | Viewed by 3820 | Submission Open

Keywords: artificial intelligence (AI); machine learning; multi-omics integration; molecular modelling; computational drug discovery; virtual screening; generative AI; explainable AI (XAI); ADMET prediction; pharmacogenomics; systems biology

(This special issue belongs to the Section Molecular Pharmacology)

Environmental Influences on Cellular Responses

edited by

Marcus Krüger

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3817 | Submission Open

Keywords: cell/environment interaction; cell signaling; mechanobiology; photobiology; thermobiology; enviromics; cell-cell communication; cell-cell interaction

(This special issue belongs to the Section Molecular Biology)

Unraveling Neuroimmune Disorders: From Pathogenic Pathways to Biomarker-Driven Precision Medicine

edited by

Mariapaola Marino

submission deadline 30 Nov 2026 | 4 articles | Viewed by 3743 | Submission Open

Keywords: innate immunity; adaptive immunity; inflammation; autoantibodies; peptides; cytokines; receptors; leukocytes; extracellular vesicles; signal transduction; apoptosis

(This special issue belongs to the Section Molecular Immunology)

New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations

edited by

Yunglung Chen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3600 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Latest Molecular Research on Renal Disease

edited by Niels Henrik Buus and Marco Eijken

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3453 | Submission Open

Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Plant Breeding

edited by

Hélia Cardoso

, Sandra Correia and

Isaura Castro

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3406 | Submission Open

Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Extracellular Vesicles in Disease and Therapeutic Applications

edited by Sunyoung Park

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3357 | Submission Open

Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Allergy and Asthma: 4th Edition

edited by

Daniel P. Potaczek

submission deadline 30 Nov 2026 | 3 articles | Viewed by 3331 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Macroporous, Mesoporous, and Microporous Materials

edited by

Magdalena Laskowska

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3149 | Submission Open

Keywords: functional materials; nanomaterials; nanostructures; molecular systems; porous materials

(This special issue belongs to the Section Materials Science)

Natural Products as Therapeutic Agents: From Molecular Targets to Cellular and Functional Modulation

edited by Su-Yun Lyu

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3071 | Submission Open

Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks

edited by Linghong Miao

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3029 | Submission Open

Keywords: fish nutrition; feed ingredients; intestinal physiology; molecular regulation; stress response and welfare; genetic mechanisms; aquaculture sustainability; omics technologies

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Neurofibromatosis Type 1: From Molecular Insights to Novel Therapies

edited by László Szabó and

Márta Medvecz

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2890 | Submission Open

Keywords: neurofibromatosis type 1; genotype–phenotype analyses; molecular pathogenesis; next-generation sequencing (NGS); molecular targeted therapy; MEK inhibitors; imaging studies

(This special issue belongs to the Section Molecular Neurobiology)

Computer Simulation Insight into Ligand–Receptor Interaction

edited by

Antonios Drakopoulos

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2771 | Submission Open

Keywords: structure–activity relationship (SAR); free energy perturbation (FEP); structure-based drug design (SBDD); machine learning in drug discovery; hybrid qm/mm methods; binding affinity prediction; enhanced sampling techniques; target binding kinetics

(This special issue belongs to the Section Molecular Informatics)

Precision Nutrition and Cancer: Molecular Insights into Cancer Prevention and Development

edited by

Da Pan

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2770 | Submission Open

Keywords: precision nutrition; cancer prevention; cancer development; nutrigenomics; personalized diets; tumor metabolism; dietary interventions

(This special issue belongs to the Section Molecular Oncology)

Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition

edited by

George Miloshev

submission deadline 30 Nov 2026 | 4 articles | Viewed by 2721 | Submission Open

Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism and Pharmacological Target of Neuroprotection

edited by

Pietro Cacialli

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2587 | Submission Open

Keywords: neurodegeneration; animal model; brain regeneration; pharmacological drug; molecular analysis

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis and Application of Natural and Inspired-Natural Products

edited by Mauro de Nisco

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2534 | Submission Open

Keywords: natural products; natural substances; derivative; synthesis; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Artificial Intelligence in Molecular Biomarker Screening

edited by

Tony Hsiu-Hsi Chen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2508 | Submission Open

Keywords: molecular biomarkers; imaging biomarkers; screening; artificial intelligence; metaverse

(This special issue belongs to the Section Molecular Informatics)

Synthesis and Activity Studies of Anticancer Compounds

edited by Agata Pacuła-Miszewska

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2502 | Submission Open

Keywords: anticancer agents; structure-activity relationship; cytotoxicity mechanisms; medicinal chemistry; drug design

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Studies of Hematologic Malignancies

edited by

Myunggon Ko

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2458 | Submission Open

Keywords: hematologic malignancies; molecular mechanisms; genetic and epigenetic aberrations; molecular diagnosis; targeted therapy and biomarkers

(This special issue belongs to the Section Molecular Oncology)

Dietary Interventions for Type 2 Diabetes: Current Evidence and Emerging Perspectives on Underlying Molecular Mechanisms

edited by Caterina Formichi

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2451 | Submission Open

Keywords: type 2 diabetes; nutritional intervention; dietary strategies; nutrients; personalized nutrition; diet; metabolic health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Insights into Antibacterial Materials

edited by

Rahela Carpa

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2447 | Submission Open

Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials

(This special issue belongs to the Section Materials Science)

Molecular Research on Aquatic Organisms

edited by

Nguyen Vu Linh

submission deadline 30 Nov 2026 | 5 articles | Viewed by 2427 | Submission Open

Keywords: aquatic biotechnology; fish immunomodulation; antimicrobial resistance; omics technologies; natural feed additives

(This special issue belongs to the Section Molecular Biology)

New Advances in Bioactive Compounds

edited by

Samuel Cota Teixeira

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2369 | Submission Open

Keywords: bioactive compound; natural products; polyphenols; carotenoids; alkaloids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Biological Markers and Molecular Targets in Bladder Cancer

edited by Stanislav Žiaran

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2337 | Submission Open

Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology

(This special issue belongs to the Section Molecular Oncology)

Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer

edited by

Elisa Dalla Pozza

and

Ilaria Dando

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2297 | Submission Open

Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone

(This special issue belongs to the Section Molecular Pharmacology)

Domestic Animal Genetics, Genomics, and Molecular Breeding

edited by

Ke Wang

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2297 | Submission Open

Keywords: genomic selection; molecular breeding; domestic animals; functional genomics; genetic improvement; product quality; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Anti-Inflammatory and Antioxidant Potential of Phytochemicals

edited by

Woo-Sik Jeong

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2243 | Submission Open

Keywords: phytochemicals; dietary bioactives; inflammation; natural compounds; functional foods; oxidative stress; cytokine modulation; NF-κB signaling; chronic diseases; plant-derived metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 1251-1300 on page 26 of 62.

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