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New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks
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New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 2342

Special Issue Editor

Dr. Linghong Miao

E-Mail Website
Guest Editor
1. Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
2. Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China
Interests: fish reproduction; fish nutritional physiology; fish metabolic regulation; molecular biology; epigenetic regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The rapid development of aquaculture has placed increasing emphasis on precise nutrition, efficient feed utilization, and improved fish health and welfare. Recent advances in nutritional biochemistry, molecular biology, and omics technologies have greatly expanded our understanding of how dietary factors influence intestinal function, metabolic regulation, stress resilience, and genetic expression in farmed fish.

This Special Issue aims to gather cutting-edge research that explores the interactions between fish nutrition, gut physiology, molecular regulatory mechanisms, and overall health and welfare. Studies addressing innovative feed ingredients, nutrient–gene interactions, stress adaptation, and the development of nutrition-based strategies to enhance aquaculture sustainability are particularly welcome.

Original research articles, comprehensive reviews, and short communications covering the following themes are encouraged. Contributions that integrate multi-omics, functional validation, or applied nutrition approaches to improve fish performance and welfare are especially appreciated.

Dr. Linghong Miao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fish nutrition
  • feed ingredients
  • intestinal physiology
  • molecular regulation
  • stress response and welfare
  • genetic mechanisms
  • aquaculture sustainability
  • omics technologies

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Published Papers (2 papers)

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Research

19 pages, 1775 KB  
Article
Arachidonic Acid Metabolic Rewiring Drives Differential Plant Protein Adaptation in Golden Pompano (Trachinotus ovatus)
by Yayang Gao, Baosuo Liu, Huayang Guo, Kecheng Zhu, Yichao Li, Lin Xian, Nan Zhang, Tengfei Zhu and Dianchang Zhang
Int. J. Mol. Sci. 2026, 27(4), 2051; https://doi.org/10.3390/ijms27042051 - 22 Feb 2026
Viewed by 1420
Abstract
The replacement of fishmeal with plant protein is widely regarded as a key strategy for sustainable aquaculture. However, carnivorous marine fish often show limited tolerance to fishmeal-free diets. Here, we investigated growth performance, hepatic physiological responses, and molecular mechanisms underlying adaptation to a [...] Read more.
The replacement of fishmeal with plant protein is widely regarded as a key strategy for sustainable aquaculture. However, carnivorous marine fish often show limited tolerance to fishmeal-free diets. Here, we investigated growth performance, hepatic physiological responses, and molecular mechanisms underlying adaptation to a soy protein concentrate-based diet (SPCD) in golden pompano (Trachinotus ovatus). An 8-week feeding trial was conducted under communal rearing conditions, followed by the phenotypic stratification of SPCD-fed fish into high- and low-growth subgroups. Growth performance, serum biochemical indices, and liver histology were assessed, and integrated transcriptomic and metabolomic analyses were performed on liver tissue. At the population level, the SPCD resulted in reduced growth, a lower feed intake, and decreased feed utilization efficiency compared with a fishmeal-based diet. Notably, marked inter-individual variation was observed: fish fed the SPCD exhibited significantly lower final body weights and a higher FCR compared with the FMD group (p < 0.001), and pronounced growth divergence was observed between the PB and PS subgroups, with a subset of SPCD-fed fish maintaining growth comparable to fishmeal-fed controls, whereas others exhibited severely constrained growth. Divergent phenotypes were associated with distinct hepatic alterations, including aggravated vacuolation, the enrichment of tight junction-related and immune regulatory pathways, and the broad reprogramming of lipid metabolism. Integrated multi-omics analysis identified arachidonic acid metabolism as the most significantly perturbed pathway, characterized by altered membrane phospholipid composition, the upregulation of RARRES3L, increased COX/LOX-derived eicosanoids, and the suppression of the CYP–EET branch. Collectively, these findings indicate that soy protein replacement induces coordinated hepatic structural and metabolic remodeling, with tight junction disruption and arachidonic acid metabolic reprogramming contributing to inflammatory imbalance and divergent growth phenotypes in T. ovatus. Full article
(This article belongs to the Special Issue New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks)
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21 pages, 5812 KB  
Article
Ferulic Acid Attenuates Heat Stress-Induced Hepatic and Intestinal Oxidative Stress and Cholesterol Metabolism Dysregulation in Juvenile Blunt Snout Bream (Megalobrama amblycephala)
by Yan Lin, Xiangjun Leng, Linjie Qian, Linghong Miao, Xiaoqin Li, Wenqiang Jiang, Siyue Lu and Zhengyan Gu
Int. J. Mol. Sci. 2026, 27(2), 925; https://doi.org/10.3390/ijms27020925 - 16 Jan 2026
Viewed by 587
Abstract
Ferulic acid (FA) is a green feed additive. To investigate the molecular mechanisms by which FA attenuates heat stress-induced hepatic and intestinal oxidative stress, as well as cholesterol metabolism disorders in Megalobrama amblycephala (9.75 ± 0.04 g), individuals were fed diets supplemented with [...] Read more.
Ferulic acid (FA) is a green feed additive. To investigate the molecular mechanisms by which FA attenuates heat stress-induced hepatic and intestinal oxidative stress, as well as cholesterol metabolism disorders in Megalobrama amblycephala (9.75 ± 0.04 g), individuals were fed diets supplemented with 0, 100, or 200 mg/kg FA for eight weeks, followed by exposure to heat stress at 34 °C for 48 h. The results indicated that FA supplementation reduced malondialdehyde levels and downregulation genes involved in inflammatory responses (e.g., interleukin-6), apoptosis (e.g., caspase 8), and endoplasmic reticulum stress (e.g., immunoglobulin binding protein) (p < 0.05), which collectively alleviated heat stress-induced hepatic and intestinal oxidative stress. FA supplementation increased the expression of ATP-binding cassette transporter A1, apolipoprotein A1, and liver X receptor α (p < 0.05), and restored liver and plasma TC levels to pre-stress levels (p < 0.05). Additionally, FA ameliorated the heat stress-induced dysbiosis of the intestinal microbiota and modulated the composition and abundance of metabolites in intestinal contents and plasma, some of which are associated with cholesterol metabolism. In conclusion, dietary FA can alleviate heat stress-induced hepatic and intestinal oxidative stress, maintain the stability of the intestinal microbiota and regulate metabolic profiles, and improve the cholesterol metabolism disorders caused by heat stress. Full article
(This article belongs to the Special Issue New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks)
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