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New Molecular Insights into Antibacterial Materials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 1051

Special Issue Editor


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Guest Editor
Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 1 M. Kogalniceanu Street, 400084 Cluj-Napoca, Romania
Interests: microbiology; microbial biotechnology; antimicrobial activity; antimicrobial materials

Special Issue Information

Dear Colleagues,

Antimicrobial resistance occurs when bacteria, viruses, fungi, and parasites become unresponsive to antimicrobial treatments by several genomic and extra-genomic mechanisms. Due to drug resistance, antibiotics and other antimicrobial treatments lose their effectiveness, making infections challenging or impossible to manage, thus increasing the risk of disease transmission as well as the incidence of serious illness, disability, and mortality.

This alarming trend requires both new antimicrobial alternatives that are specific for the human health, food production, animal, and environmental sectors and unique new antimicrobial strategies applicable across all these areas. There is an urgent need for novel treatment approaches, driving progress aimed at creating innovative solutions to tackle resistant pathogens and improve public health, including antimicrobial materials.

Molecular strategies for antimicrobial resistance include the employment of different novel materials possessing antimicrobial characteristics. It is the case of nanomaterials, nanoparticles (NPs) (silver, copper, and zinc oxide NPs), biopolymers (chitosan, alginate, and levan), and antimicrobial peptides. Smart materials that offer specific and regulated antimicrobial effects, including plasma treatments or chemical grafting modifying the surfaces of materials to trigger or increase their antimicrobial properties, are other promising antimicrobial solutions currently explored to fight pathogen resistance.

Such developments are vital in combating infections and creating safer healthcare conditions. Here, both experimental and review articles as well as communication on the reported topics are welcome.

Dr. Rahela Carpa
Guest Editor

Manuscript Submission Information

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Keywords

  • antimicrobial resistance
  • nanoparticles
  • biopolymers
  • antimicrobial peptides
  • antimicrobial materials

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Published Papers (1 paper)

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Review

19 pages, 1055 KB  
Review
Hydrogel Design Based on Bacterial Exopolysaccharides: The Biomedical Promise of Levan
by Andrada Ioana Popa, Rahela Carpa and Anca Farkas
Int. J. Mol. Sci. 2025, 26(22), 10828; https://doi.org/10.3390/ijms262210828 - 7 Nov 2025
Viewed by 762
Abstract
Bacterial exopolysaccharides have emerged as versatile biopolymers for the design of advanced hydrogels with adjustable physico-chemical, mechanical, and biological properties. Among these, levan, a fructose-based exopolysaccharide synthesized by various microbial species, has attracted increasing attention due to its unique structural features, high biocompatibility, [...] Read more.
Bacterial exopolysaccharides have emerged as versatile biopolymers for the design of advanced hydrogels with adjustable physico-chemical, mechanical, and biological properties. Among these, levan, a fructose-based exopolysaccharide synthesized by various microbial species, has attracted increasing attention due to its unique structural features, high biocompatibility, and inherent bioactivity. This review provides a comprehensive overview of hydrogel systems derived from bacterial exopolysaccharides, with a particular focus on levan-based hydrogels. We discuss the molecular structure, synthesis pathways, and physico-chemical characteristics of levan that underpin its hydrogel-forming ability. Emphasis is placed on design strategies, including chemical modification, crosslinking approaches, and composite formation, that enable fine-tuning of mechanical strength, swelling behavior, and degradation kinetics. This review further highlights biomedical applications of levan-based hydrogels, encompassing drug delivery, wound healing, rejuvenation, tissue engineering, regenerative medicine, and bioprinting, while addressing current limitations and future research directions. By elucidating the structure–function relationships and emerging fabrication methodologies, this review underscores the biomedical promise of levan as a sustainable and functional biopolymer for next-generation hydrogel technologies. Full article
(This article belongs to the Special Issue New Molecular Insights into Antibacterial Materials)
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