New Advances in Bioactive Compounds

Dear Colleagues,

This Special Issue, “New Advances in Bioactive Compounds”, aims to present recent progress in the discovery, mechanistic elucidation, and translational application of bioactive compounds within the molecular and biomedical sciences. Bioactive compounds encompass a wide range of molecules obtained from natural sources, synthetic and semi-synthetic approaches, as well as drug repositioning strategies, all of which exert measurable biological effects by modulating molecular and cellular processes. These compounds influence key pathways related to cellular signaling, gene regulation, metabolism, and immune responses, positioning them as promising candidates for therapeutic innovation.

Advances in molecular biology, omics technologies, computational modeling, and experimental systems have significantly expanded our understanding of the molecular targets and mechanisms of action underlying bioactivity. Despite this progress, challenges remain in translating mechanistic insights into clinically relevant and safe interventions. This Special Issue seeks to address these challenges by bringing together original research articles and high-quality reviews that integrate mechanistic evidence with translational perspectives.

Topics of interest include molecular targets and signaling networks, structure–activity relationships, experimental and computational models, nanotechnology-based delivery systems, and drug repositioning approaches applied to cancer, infectious, inflammatory, and metabolic diseases. By emphasizing mechanism-driven research with translational relevance, this Special Issue aims to foster interdisciplinary collaboration and advance the rational development of bioactive compounds for biomedical applications.

Dr. Samuel Cota Teixeira
Guest Editor

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