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The Role of Extracellular Vesicles in Disease and Therapeutic Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 996

Special Issue Editor


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Guest Editor
School of Mechanical Engineering, Yonsei University, Seoul, Republic of Korea
Interests: microfluidic; cancer diagnosis; drug delivery

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication, playing pivotal roles in various physiological and pathological processes. These membrane-bound nanoparticles, including exosomes, microvesicles, and apoptotic bodies, are involved in immune modulation, tissue regeneration, and disease progression. Notably, EVs have gained significant attention for their potential in disease diagnostics, therapeutics, and drug delivery applications. This Special Issue aims to explore the diverse functions of EVs in different diseases, including cancer, neurodegenerative disorders, metabolic syndromes, and infectious diseases. We welcome original research articles and reviews that provide novel insights into EV biogenesis, cargo profiling, functional mechanisms, and their translational applications in clinical settings. Studies utilizing cutting-edge technologies such as single-vesicle analysis, multi-omics approaches, and engineered EVs for therapeutic interventions are highly encouraged.By gathering the latest advances in this rapidly evolving field, this Special Issue seeks to enhance our understanding of the intricate roles of EVs in health and disease, fostering innovative strategies for diagnosis and treatment. We invite researchers to contribute to this endeavor by submitting their high-quality studies. 

Dr. Sunyoung Park
Guest Editor

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Keywords

  • extracellular vesicles (EVs)
  • disease biomarkers
  • EV-based therapeutics
  • cancer diagnosis
  • drug delivery
  • immune modulation
  • regenerative medicine

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Published Papers (1 paper)

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9 pages, 647 KB  
Brief Report
Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Oral Mucosal Engraftment in Urethral Reconstruction: Influence of Tissue Origin and Culture Growth Phase (Log vs. Stationary) on miRNA Content
by Daisuke Watanabe, Akio Mizushima and Akio Horiguchi
Int. J. Mol. Sci. 2025, 26(19), 9412; https://doi.org/10.3390/ijms26199412 - 26 Sep 2025
Viewed by 747
Abstract
Urethral stricture involves fibrotic narrowing of the urethral mucosa and spongiosum. Although urethroplasty using oral mucosal grafts is the gold standard for complex cases due to its high success rate, technical complexity limits its broader adoption. To address this, endoscopic transplantation of oral [...] Read more.
Urethral stricture involves fibrotic narrowing of the urethral mucosa and spongiosum. Although urethroplasty using oral mucosal grafts is the gold standard for complex cases due to its high success rate, technical complexity limits its broader adoption. To address this, endoscopic transplantation of oral mucosal tissue has been proposed. While feasibility has been demonstrated, clinical efficacy remains suboptimal. Developing adjunctive factors that facilitate mucosal engraftment may improve outcomes of endoscopic transplantation. Extracellular vesicles (EVs)—membrane-bound nanoparticles secreted by cells that deliver miRNAs and other bioactive molecules—have recently emerged as promising candidates. We investigated EVs derived from four mesenchymal stromal cell (MSC) sources—stem cells from human exfoliated deciduous teeth (SHED), adipose tissue, umbilical cord, and bone marrow (BM)—isolated during both logarithmic (log) and stationary culture phases. miRNA profiling revealed distinct phase- and origin-specific signatures. SHED-derived EVs from the log phase and bone marrow-derived EVs from the stationary phase expressed miR-31, the let-7 family, and miR-205, suggesting early wound healing potential. In contrast, stationary-phase SHED-EVs and log-phase BM-MSC-EVs were enriched in the miR-99 family and miR-31, indicating potential roles in epithelial stabilization and fibrosis modulation. These findings support phase-specific application of MSC-EVs to optimize mucosal engraftment in transurethral reconstruction. Full article
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