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Molecular Research on Aquatic Organisms
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Molecular Research on Aquatic Organisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1507

Editor

Dr. Nguyen Vu Linh

E-Mail Website
Guest Editor
Aquatic Biotechnology Laboratory, Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
Interests: fish; aquatic biotechnology; fish immunomodulation; sustainable disease management; probiotic biotechnology

Special Issue Information

Dear Colleagues,

Aquatic ecosystems harbour the majority of the Earth's biodiversity and underpin global food security, yet the molecular mechanisms governing the physiology, health, and adaptive resilience of aquatic organisms remain incompletely resolved. This Special Issue unifies frontier molecular research spanning genomics, transcriptomics, proteomics, metabolomics, and epigenomics, with particular emphasis on integrative multi-omics approaches applied across the full taxonomic breadth of aquatic life — from fish and crustaceans to molluscs, echinoderms, marine algae, and their associated microbial communities. Priority themes encompass single-cell and spatial transcriptomics, CRISPR-based functional genomics, epigenetic regulation and transgenerational inheritance, molecular host–pathogen–microbiome interactions, innate immune memory and trained immunity, molecular mechanisms of climate adaptation and thermal acclimation, molecular ecotoxicology of emerging contaminants, environmental DNA (eDNA) metabarcoding and biosensing, conservation genomics, microbiome engineering, and translational aquaculture biotechnology.

This Special Issue welcomes original research articles, systematic reviews, meta-analyses, methodology articles, and perspectives or opinion pieces from researchers at all career stages. This collection aims to provide an inclusive, interdisciplinary platform that bridges fundamental molecular discovery with sustainable aquaculture innovation and aquatic biodiversity conservation, fostering cross-disciplinary dialogue among biologists, ecologists, biotechnologists, and aquaculture practitioners worldwide.

Dr. Nguyen Vu Linh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aquatic biotechnology
  • fish immunomodulation
  • antimicrobial resistance
  • omics technologies
  • natural feed additives

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Published Papers (3 papers)

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Research

18 pages, 878 KB  
Article
Parallel Recovery Dynamics of Circulating and Tissue-Resident Hemocytes Following Hemolymph Withdrawal in Pomacea canaliculata
by Chiara Losi, Anita Ferri, Monica Montanari, Nicola Franchi, Gabriele Sansalone, Sandro Sacchi and Davide Malagoli
Int. J. Mol. Sci. 2026, 27(15), 6619; https://doi.org/10.3390/ijms27156619 (registering DOI) - 24 Jul 2026
Abstract
In vertebrates, circulating and tissue-resident immune cells contribute to host defense and tissue homeostasis. Their balance is maintained through hematopoiesis and anatomical reservoirs. In mollusks, this balancing is poorly investigated. Thus, the dynamics of circulating and tissue-resident hemocytes after a hemolymph withdrawal were [...] Read more.
In vertebrates, circulating and tissue-resident immune cells contribute to host defense and tissue homeostasis. Their balance is maintained through hematopoiesis and anatomical reservoirs. In mollusks, this balancing is poorly investigated. Thus, the dynamics of circulating and tissue-resident hemocytes after a hemolymph withdrawal were analyzed in Pomacea canaliculata, a snail that allows repeated hemolymph withdrawals and possesses posterior kidney (PK) cell aggregates known as hemocyte islets. In the absence of specific hemocyte markers, flow cytometry data revealed dynamic changes in circulating hemocyte number and populations within 48 h following hemolymph withdrawal. In addition, computer-assisted image analysis of histological sections showed a significant transient reduction in PK hemocyte-islet area. Analyses of publicly available P. canaliculata transcriptomes revealed predominant and highly variable expression of two hematopoiesis-related genes, namely Transglutaminase (PcTGase) and Hematopoietically expressed homeobox protein (PcHhex), in circulating hemocytes and PK. Fluorescence in situ hybridization highlighted constitutive PcTGase and PcHhex expression within PK hemocyte islets. RT-qPCR experiments confirmed transcriptomic data on PcTGase and PcHhex constitutive expression, without significant modulation following hemolymph withdrawal. Collectively, these findings provide the first evidence of parallel recovery dynamics involving circulating hemocytes and PK hemocyte islets in P. canaliculata. Full article
(This article belongs to the Special Issue Molecular Research on Aquatic Organisms)
24 pages, 22515 KB  
Article
The RyR-like-FKBP12-PKA Complex Regulates Intracellular Ca2+, Unfolded Protein Response and Apoptosis in Patinopecten yessoensis Under High-Temperature Stress
by Wenfei Gu, Qingyu Peng, Chuanyan Yang, Hongbo Lu, Dongli Jiang, Lingling Wang and Linsheng Song
Int. J. Mol. Sci. 2026, 27(13), 5859; https://doi.org/10.3390/ijms27135859 - 29 Jun 2026
Viewed by 254
Abstract
Ryanodine receptor-like (RyR-like) is a key endoplasmic reticulum (ER) Ca2+ release channel governing intracellular Ca2+ homeostasis and cellular stress responses in invertebrates. However, its function in bivalves under high-temperature stress remains unclear. In the present study, one RyR-like was identified from [...] Read more.
Ryanodine receptor-like (RyR-like) is a key endoplasmic reticulum (ER) Ca2+ release channel governing intracellular Ca2+ homeostasis and cellular stress responses in invertebrates. However, its function in bivalves under high-temperature stress remains unclear. In the present study, one RyR-like was identified from Yesso scallop Patinopecten yessoensis (PyRyR-like). Its function in regulating intracellular Ca2+, IRE1α-mediated unfolded protein response (UPR) and apoptosis in the mantle after high-temperature (25 °C) treatment was investigated using molecular cloning, qRT-PCR, Western blot, pull-down assay, cellular calcium imaging, TUNEL and histology assays; High temperature treatment significantly increased intracellular Ca2+ content at 1 and 6 h (p < 0.05), but decreased it at 3, 12 and 24 h (p < 0.05); meanwhile, the cAMP level, PyPKA activity, mRNA expression level of PyRyR-like, and protein expression levels of PyFKBP12 and PyGRP78 were significantly increased at different times. However, high temperature did not affect the expression level of PyNVL and PyXBP1(S). The SPRY and RYR domains of PyRyR-like separately interacted with PyFKBP12 and PyPKA. Moreover, RyR antagonist Dantrolene reversed high-temperature-induced alterations in Ca concentration, PKA activity, and core UPR- and apoptosis-related molecules, and suppressed Caspase-3 activity. These findings suggest that PyRyR-like plays an important role in the high-temperature response of scallops by regulating intracellular Ca2+ homeostasis and mediating UPR activation and apoptosis, providing new insight into the molecular mechanism underlying scallop adaptation to high temperature. Full article
(This article belongs to the Special Issue Molecular Research on Aquatic Organisms)
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19 pages, 29222 KB  
Article
Comparative Health Assessment of Crassostrea belcheri from Breeding and Farming Sites in Thailand: Histopathological, Apoptotic, and Molecular Evidence
by Supatcha Chooseangjaew, Suwat Tanyaros, Narit Thaochan, Sirilak Dusitsittipon, Natthawut Charoenphon, Gen Kaneko, Supapong Imsonpang, Nabhasbhichayabha Daewang, Kitipong Angsujinda, Kitiya Kongthong and Sinlapachai Senarat
Int. J. Mol. Sci. 2026, 27(12), 5351; https://doi.org/10.3390/ijms27125351 - 13 Jun 2026
Viewed by 224
Abstract
Oyster health is important for aquaculture productivity and sustainability. In Thailand, the white scar oyster, Crassostrea belcheri, is being promoted for cultivation, yet its health status has not been compared between research breeding and community farming sites. This study evaluated histopathological features, [...] Read more.
Oyster health is important for aquaculture productivity and sustainability. In Thailand, the white scar oyster, Crassostrea belcheri, is being promoted for cultivation, yet its health status has not been compared between research breeding and community farming sites. This study evaluated histopathological features, ultrastructure, apoptosis, and defender against apoptotic death 1 (dad1) gene expression in sexually mature C. belcheri collected from these two sites. Gill tissues were examined by histology, transmission electron microscopy, TUNEL assay, and gene expression analysis, while organ condition was assessed using a Health Assessment Index (HAI). The proportion of TUNEL-positive cells in the gills and mantle differed significantly between sites (p < 0.05), with higher levels in oysters from the farming site. In contrast, TUNEL-positive cells in the digestive gland did not differ significantly between sites, although brown cells were observed only in the digestive gland of oysters from the breeding site, suggesting possible physiological stress. To assess the expression level of dad1 in oysters cultured under different conditions, RT-qPCR revealed no significant difference between the two sites. The breeding site also had lower temperature and salinity than the farming site. Overall, these findings suggest that site-specific environmental conditions may influence gill health and stress-related responses in C. belcheri, providing baseline information for oyster health assessment and aquaculture management. Full article
(This article belongs to the Special Issue Molecular Research on Aquatic Organisms)
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