New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 23
Special Issue Editor
Interests: cancer; myeloproliferative neoplasms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Myeloproliferative neoplasms represent a heterogenous group of chronic hematological malignancies that includes polycythemia vera, essential thrombocythemia, and myelofibrosis, characterized by excessive myeloproliferation and chronic systemic inflammation. At the molecular level, most of these diseases show a hyperactivation of the JAK/STAT signaling pathway as a consequence of driver mutations in genes such as JAK2, CALR, or MPL. Although progress has been made in characterizing the molecular basis of these diseases, there is still a need to identify more effective personalized treatments. This Special Issue aims to collect original research or review articles focusing on the new advances in the molecular mechanisms underlying the development and progression of these diseases. Subjects such as the development of new potential treatments or combination strategies, genetic and epigenetic factors involved in MPN progression, identification of new biomarkers for early diagnosis, response and resistance to therapy, and the impact of inflammation and the microenvironment on MPN pathogenesis are welcome.
Dr. Laura Georgiana Necula
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- myeloproliferative neoplasms
- molecular diagnostic
- targeted therapy
- biomarkers
- inflammation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
