New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms

Dear Colleagues,

Myeloproliferative neoplasms represent a heterogenous group of chronic hematological malignancies that includes polycythemia vera, essential thrombocythemia, and myelofibrosis, characterized by excessive myeloproliferation and chronic systemic inflammation. At the molecular level, most of these diseases show a hyperactivation of the JAK/STAT signaling pathway as a consequence of driver mutations in genes such as JAK2, CALR, or MPL. Although progress has been made in characterizing the molecular basis of these diseases, there is still a need to identify more effective personalized treatments. This Special Issue aims to collect original research or review articles focusing on the new advances in the molecular mechanisms underlying the development and progression of these diseases. Subjects such as the development of new potential treatments or combination strategies, genetic and epigenetic factors involved in MPN progression, identification of new biomarkers for early diagnosis, response and resistance to therapy, and the impact of inflammation and the microenvironment on MPN pathogenesis are welcome.

Dr. Laura Georgiana Necula
Guest Editor

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