Unraveling Neuroimmune Disorders: From Pathogenic Pathways to Biomarker-Driven Precision Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 8
Special Issue Editor
2. Fondazione Policlinico Universitario “A. Gemelli” IRCCS, 00168 Rome, Italy
Interests: immunology; autoimmunity; inflammation; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroimmune disorders represent a huge burden for society. The pathogenetic mechanisms arise from the complexity of interactions between the immune system dysregulated or autoimmune response that, through autoantibodies and/or neuroimmune-related cells (T cells, B cells, neutrophils, and macrophages), mediates inflammatory damage targeting central or peripheral nervous system. Prominent examples of neuroimmune disorders encompass multiple sclerosis, miasthenia gravis, and neuromyelitis optica. In these conditions, inflammation, the long arm of innate immunity, may be considered the mediator of the final effects of deregulation. Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis show dysregulated neuroimmune and inflammatory responses, with the activation of neurons, glial cells, and infiltration of peripheral immune cells into the brain thanks to a circuit involving proinflammatory cytokines, chemokines, and neurotoxic mediators.
Accordingly, besides the assessment of specific autoantibodies when the autoantigen is known, cellular and molecular biomarkers are largely involved in the diagnosis, prognosis, response to therapies, and follow-up for a prediction of changes in disease activity. Taking into account the individual and genetic susceptibility as well as the wide range of environment risk factors that concur with the pathogenesis, the importance of research to set up and validate novel, effective, and personalized biomarkers of neuroimmune conditions stands alone. This Special Issue is devoted to the most recent results aimed at exploiting the clinical potential of biomarkers measuring the disordered immune response.
Potential topics include, but are not limited to, the following:
- Innate immunity;
- Adaptive immunity;
- Inflammation;
- Autoantibodies;
- Peptides;
- Cytokines;
- Receptors;
- Leukocytes;
- Extracellular vesicles;
- Signal transduction;
- Apoptosis.
Dr. Mariapaola Marino
Guest Editor
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Keywords
- innate immunity
- adaptive immunity
- inflammation
- autoantibodies
- peptides
- cytokines
- receptors
- leukocytes
- extracellular vesicles
- signal transduction
- apoptosis
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