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Synthesis and Application of Natural and Inspired-Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 335

Special Issue Editor


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Guest Editor
Department of Sciences, University of Basilicata, 85100 Potenza, Italy
Interests: drug discovery; new synthetic methods; chalcogen compounds; antioxidant properties; food chemistry; natural products; neurodegenerative diseases; pharmacological or toxicology effects

Special Issue Information

Dear Colleagues,

The therapeutic panorama has been recently changed, pointing out the importance of natural sources and their derivatives. Natural substances, a large and diverse group of substances such as alkaloids, flavonoids, glycosides, polyphenols, amino acids, and peptides of plant, microbial, and animal origin, increasingly represent a huge potential reservoir for identifying new therapeutic targets, developing new therapies, and understanding complex biological mechanisms.

Natural products are the link between ancient wisdom and modern research; in fact, they are able to express different activities such as antioxidant, antifungal, antibacterial, anti-inflammatory, antiviral, hepatoprotective, and neuroprotective, and therefore they are increasingly used.

Furthermore, in recent years, numerous studies have demonstrated the ability of compounds of natural origin to improve the effects of antitumor or antimicrobial drugs, helping to overcome the phenomenon of resistance of tumor cells or microorganisms to treatment with drugs or antibiotics.

This Special Issue focuses on the preparation and new approach to the use of natural products or their derivatives towards emerging therapeutic strategies in the food (novel food), pharmaceutical, and cosmetic fields.

Dr. Mauro de Nisco
Guest Editor

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Keywords

  • natural products
  • natural substances
  • derivative
  • synthesis
  • application

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Published Papers (1 paper)

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Research

14 pages, 853 KB  
Article
Catalyst-Free Assembly of δ-Lactam-Based Hydrazide–Hydrazone Compounds from 3-Arylglutaconic Anhydrides and Aldazines
by Anna Ananeva, Elizaveta Karchuganova, Dar’ya Spiridonova, Grigory Kantin and Olga Bakulina
Int. J. Mol. Sci. 2025, 26(18), 8834; https://doi.org/10.3390/ijms26188834 - 10 Sep 2025
Viewed by 138
Abstract
A novel general approach to cyclic hydrazide–hydrazone compounds with a dihydropyridine-2-one core has been developed, involving annulation of symmetrical aldazines with 3-arylglutaconic anhydrides. This approach provides the benefits of straightforward and catalyst-free procedures, diastereoselectivity, and the ability to switch between two isomeric dihydropyridine-2-one [...] Read more.
A novel general approach to cyclic hydrazide–hydrazone compounds with a dihydropyridine-2-one core has been developed, involving annulation of symmetrical aldazines with 3-arylglutaconic anhydrides. This approach provides the benefits of straightforward and catalyst-free procedures, diastereoselectivity, and the ability to switch between two isomeric dihydropyridine-2-one cores based on the reaction temperature. Several post-modifications were performed on the side functional groups and the core to demonstrate the synthetic potential of the resulting products. This approach significantly expands the chemical diversity of medicinally relevant N-functionalized δ-lactams. Full article
(This article belongs to the Special Issue Synthesis and Application of Natural and Inspired-Natural Products)
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