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Domestic Animal Genetics, Genomics, and Molecular Breeding

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 March 2026 | Viewed by 193

Special Issue Editor

Zhanjiang Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524013, China
Interests: functional genomics; product quality; reproduction; molecular breeding; genomic selection; domestic animals; genetic improvement

Special Issue Information

Dear Colleagues,

Against the backdrop of a rapidly expanding global population and sustained economic growth in developing regions, the demand for animal-derived products continues to intensify. To address this challenge, a sustainable and efficient expansion of livestock production is essential. Advances in genetics, genomics, and molecular breeding are critical to improving key traits such as productivity, disease resistance, environmental adaptability, and animal welfare. At the same time, there is growing consumer emphasis on quality, safety, and ethical husbandry practices, driving the need for innovative breeding strategies that align with these values.

This Special Issue, titled "Domestic Animal Genetics, Genomics, and Molecular Breeding", aims to gather high-quality research and review articles that explore the application of modern genetic and genomic tools in the enhancement of domestic animals. We welcome contributions that focus on genome-wide association studies (GWAS), genomic selection, gene editing, functional genomics, molecular marker, and other molecular approaches aimed at optimizing animal production, health, reproduction, and overall resilience.

We look forward to receiving your valuable research and insights to help advance this important field.

Dr. Ke Wang
Guest Editor

Manuscript Submission Information

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Keywords

  • genomic selection
  • molecular breeding
  • domestic animals
  • functional genomics
  • genetic improvement
  • product quality
  • reproduction

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Published Papers (1 paper)

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Research

15 pages, 3387 KB  
Article
Transcriptome Dynamics and Regulatory Networks of Postnatal Muscle Development in Leizhou Black Goats
by Jiancheng Han, Jing Huang, Mengning Xu, Yuelang Zhang, Ke Wang and Hanlin Zhou
Int. J. Mol. Sci. 2026, 27(1), 88; https://doi.org/10.3390/ijms27010088 (registering DOI) - 21 Dec 2025
Abstract
Postnatal muscle development involves complex transcriptional regulation that remains poorly characterized in goats. This study employed RNA-Seq to profile the Longissimus dorsitranscriptome of Leizhou Black goats across three developmental stages: birth, six months, and two years. We identified dynamic gene expression patterns, widespread [...] Read more.
Postnatal muscle development involves complex transcriptional regulation that remains poorly characterized in goats. This study employed RNA-Seq to profile the Longissimus dorsitranscriptome of Leizhou Black goats across three developmental stages: birth, six months, and two years. We identified dynamic gene expression patterns, widespread alternative splicing events, and stage-specific co-expression networks that collectively orchestrate muscle maturation. A significant transcriptional shift occurred between six months and two years, marked by the downregulation of proliferation-related genes (e.g., RRM2, TOP2A) and the activation of pathways governing muscle contraction and energy metabolism. Functional enrichment analyses highlighted the importance of PI3K-Akt, PPAR, and calcium signaling pathways throughout development. Additionally, 905 novel transcripts were discovered, many enriched in mitochondrial functions, indicating incompleteness in the current goat genome annotation. Weighted gene co-expression network analysis revealed modules correlated with developmental stages, and protein–protein interaction analysis identified hub genes regulating cell cycle progression and muscle function. Key results were validated via qRT-PCR, confirming the temporal expression patterns of genes such as CYP4B1, HACD1, and ACTC1. These findings provide mechanistic insights into the transcriptional reprogramming driving postnatal muscle development and offer valuable genetic resources for improving meat production in goats through molecular breeding. Full article
(This article belongs to the Special Issue Domestic Animal Genetics, Genomics, and Molecular Breeding)
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