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Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition
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Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 652

Special Issue Editor

Prof. Dr. George Miloshev

E-Mail Website
Guest Editor
Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: epigenetics; chromatin; genotoxicology; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Issues, “Application of Natural Products in Biomedicine and Pharmacotherapy and “Application of Natural Products in Biomedicine and Pharmacotherapy: 2nd Edition”.

Natural products are derived from biomolecules, compounds, and extracts obtained from plants or animals, and humans have used them for millennia. Although many natural products exert well-documented beneficial effects on human health, the occurrence of unwanted side effects cannot be entirely ruled out. Therefore, scientific research on natural products and their applications at the molecular, cellular, and organismal levels remains highly valuable.

This Special Issue aims to showcase high-quality, modern research and the latest insights into the applications of natural products. We invite researchers to contribute reviews or original research articles that explore the properties of natural products at the molecular, cellular, or organismal levels.

Subtopics may include the following:

  • Cellular metabolism of natural products;
  • Genotoxicity and allergenicity of natural products;
  • Epigenetic influence of natural products;
  • Natural products and aging.

Prof. Dr. George Miloshev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • biomedicine
  • genotoxicity
  • epigenetics
  • aging

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Published Papers (1 paper)

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Research

23 pages, 9280 KB  
Article
Endarachne binghamiae Extract Alleviates Colitis by Suppressing NLRP3 Inflammasome Activation via Regulation of NOX–iNOS Crosstalk
by Sang Seop Lee, Sang Hoon Lee, So Yeon Kim, Bong Ho Lee and Yung-Choon Yoo
Int. J. Mol. Sci. 2026, 27(6), 2674; https://doi.org/10.3390/ijms27062674 - 14 Mar 2026
Viewed by 372
Abstract
Inflammatory bowel disease (IBD) is triggered by genetic predisposition and chronic inflammation, with aberrant activation of the innate immune complex NLRP3 inflammasome playing a pivotal role in its pathogenesis. In this study, we investigated the effects of a hot water extract from the [...] Read more.
Inflammatory bowel disease (IBD) is triggered by genetic predisposition and chronic inflammation, with aberrant activation of the innate immune complex NLRP3 inflammasome playing a pivotal role in its pathogenesis. In this study, we investigated the effects of a hot water extract from the brown alga Endarachne binghamiae (EB-WE) on the inhibition of NLRP3 inflammasome activation, with a focus on its antioxidant properties, in various inflammation models. In bone marrow-derived macrophages (BMDMs), NLRP3 inflammasome activation was induced using LPS and ATP, and EB-WE pretreatment (100, 200 µg/mL) significantly reduced the secretion of IL-1β and IL-18. Confocal immunofluorescence analysis further confirmed that EB-WE suppressed the formation of the NLRP3-ASC/caspase-1 complex. Furthermore, the in vivo anti-IBD efficacy of EB-WE was assessed using a DSS-induced mouse model, in which colonic inflammation and NLRP3-mediated responses were prominent. Oral administration of EB-WE (2 or 5 mg/day) markedly ameliorated clinical symptoms, such as weight loss, diarrhea, and rectal bleeding, and significantly reduced the disease activity index (DAI). EB-WE also decreased serum pro-inflammatory cytokine levels and the expression of NLRP3 inflammasome-related molecules in colon tissue at both the gene and protein levels. In both BMDMs and the IBD mouse model, we further analyzed the upstream regulatory pathway involving NOX2-iNOS. EB-WE efficiently inhibited the activation of the NOX-iNOS axis and NF-κB phosphorylation, thereby alleviating inflammasome activation associated with DSS-induced oxidative stress and neutrophil/macrophage infiltration. Collectively, these results demonstrate that EB-WE effectively suppresses the formation and activation of the NLRP3 inflammasome by modulating the NOX-iNOS axis and the NF-κB pathway via antioxidant mechanisms. These findings suggest that EB-WE holds promise as a novel marine-derived natural therapeutic agent for the treatment of chronic inflammatory diseases. Full article
(This article belongs to the Special Issue Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition)
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