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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Active Substances in Human Diseases

edited by

Hyeung-Jin Jang

submission deadline 30 Nov 2026 | 4 articles | Viewed by 14779 | Submission Open

Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Modulation of the Immune System and Oxidative Stress in Liver Illnesses

edited by

Vlad Pădureanu

and Dan Ionuț Gheonea

submission deadline 30 Nov 2026 | 2 articles | Viewed by 14437 | Submission Open

Keywords: oxidative stress; liver illnesses; immune system; inflammatory

(This special issue belongs to the Section Molecular Immunology)

New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition

edited by

Mariapaola Marino

submission deadline 30 Nov 2026 | 5 articles | Viewed by 14217 | Submission Open

Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Steatotic Liver Disease: From Bench to Bedside and Back

edited by

Federico Salomone

submission deadline 30 Nov 2026 | 2 articles | Viewed by 11997 | Submission Open

Keywords: MASLD; ALD; MetALD; fibrosis; hepatocellular carcinoma; molecular mechanisms; molecular markers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurogenesis and Neurodegeneration: Insights into Regeneration and the Impact of Neurotrophins

edited by

Eva Terzibasi Tozzini

submission deadline 30 Nov 2026 | 4 articles | Viewed by 11523 | Submission Open

Keywords: neurogenesis; neurodegeneration and regeneration; neurotrophins; brain plasticity

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Vitamin D in Human Health and Diseases, 5th Edition

edited by

Loredana Bergandi

and

Francesca Silvagno

submission deadline 30 Nov 2026 | 5 articles | Viewed by 11351 | Submission Open

Keywords: vitamin D; vitamin D receptor; calciferol; health; disease; inflammation; gene transcription; cell metabolism; differentiation; vitamin D deficiency; vitamin D supplementation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neurological Diseases: From Physiology to Therapy

edited by

Vasileios Papaliagkas

submission deadline 30 Nov 2026 | 2 articles | Viewed by 11052 | Submission Open

Keywords: neurophysiology; genetics; Alzheimer’s disease; neurological diseases; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Functional Food Ingredients in Immunity Improvement

edited by

Prodromos Skenderidis

submission deadline 30 Nov 2026 | 1 articles | Viewed by 10984 | Submission Open

Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Challenges

edited by

Odília Queirós

and

Patrícia M. A. Silva

submission deadline 30 Nov 2026 | 3 articles | Viewed by 10567 | Submission Open

Keywords: cancer therapy; MultiDrug Resistance (MDR); Pgp; efflux pumps; tumor microenvironment; anticancer drug target; combination therapy; novel anticancer agents

(This special issue belongs to the Section Molecular Biology)

The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights

edited by Ramos-López Omar

submission deadline 30 Nov 2026 | 6 articles | Viewed by 10548 | Submission Open

Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Treatment in Cardiovascular Diseases

edited by Calogera Pisano,

Carmela Rita Balistreri

and Giuseppe Raffa

submission deadline 30 Nov 2026 | 4 articles | Viewed by 10400 | Submission Open

Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Focus on Endocrine and Metabolic Research Priorities in PCOS/PMOS

edited by

Jim Parker

submission deadline 30 Nov 2026 | 3 articles | Viewed by 10339 | Submission Open

Keywords: polycystic ovary syndrome; metabolism; insulin resistance; inflammation; hyperandrogenism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

CRISPR/Cas Systems and Genome Editing—3rd Edition

edited by

Dmitry Karpov

submission deadline 30 Nov 2026 | 6 articles | Viewed by 9605 | Submission Open

Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Urological Cancer

edited by Andrea Zivi and

Sara Merler

submission deadline 30 Nov 2026 | 1 articles | Viewed by 9301 | Submission Open

Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies

(This special issue belongs to the Section Molecular Oncology)

Plant Physiology and Molecular Nutrition: 2nd Edition

edited by

Shu Yuan

and

Guijie Lei

submission deadline 30 Nov 2026 | 6 articles | Viewed by 8929 | Submission Open

Keywords: plant nutritional physiology; nutrient signaling; phytohormones; gene regulation network; environment and nutrition crosstalk

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Molecular Research in Cardiology and Treatment Approaches

edited by Ludger Hauck

submission deadline 30 Nov 2026 | 3 articles | Viewed by 8415 | Submission Open

Keywords: TAp63; EzH2; histone methyltransferase; cardiomyocyte proliferation; myocardial infarction; heart regeneration; heart repair; epigenetic regulation; cardiac regeneration; Skp2-p27KIP1 pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 3rd Edition

edited by

Jarosław Nuszkiewicz

and

Alina Woźniak

submission deadline 30 Nov 2026 | 6 articles | Viewed by 8316 | Submission Open

Keywords: oxidative stress; redox homeostasis; reactive oxygen species (ROS); redox signaling; antioxidants and defense mechanisms; metabolic regulation; inflammation and redox imbalance; mitochondrial dysfunction; biomarkers of oxidative stress; therapeutic redox modulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 30 Nov 2026 | 6 articles | Viewed by 8290 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms in Neuroinflammation Research

edited by

Robert P. Ostrowski

submission deadline 30 Nov 2026 | 3 articles | Viewed by 8094 | Submission Open

Keywords: non-coding RNA; nucleic acids; inflammatory cells; inflammatory mediators; neurotransmitters; neuroinflammation; immune cells; neurodegenerative diseases; cerebrovascular diseases; brain tumors

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Plastic-Related Toxicity: From Environmental Exposure to Human Health

edited by

Antonietta Santoro

and

Marta Anna Szychlinska

submission deadline 30 Nov 2026 | 4 articles | Viewed by 7316 | Submission Open

Keywords: (bio)plastic- and (bio)polymer-related toxicity; microplastic and nanoplastic accumulation/degradation in mammals; cell cultures; human health; in vivo models; epigenetics effects; endocrine disruptor properties of bioplastics; plastics and inflammation; plastics in neurodegeneration and neuroinflammation; reproduction; cell metabolism; immunomodulation

(This special issue belongs to the Section Molecular Toxicology)

Future Challenges and Innovation in Gynecological Oncology

edited by

Alejandro Herreros-Pomares

submission deadline 30 Nov 2026 | 4 articles | Viewed by 7169 | Submission Open

Keywords: gynecologic oncology; molecular biomarkers; personalized medicine; ovarian cancer; immunotherapy; tumor microenvironment; drug resistance; translational research

(This special issue belongs to the Section Molecular Oncology)

Molecular Aspects of Viral Pathogenesis: From Infection to Host Response

edited by

Quang Duy Trinh

submission deadline 30 Nov 2026 | 6 articles | Viewed by 6945 | Submission Open

Keywords: viruses; viral pathogenesis; virus–host interaction; molecular virology; immunity; viral entry; viral replication; emerging viruses; infectious diseases; inflammation

(This special issue belongs to the Section Molecular Microbiology)

Metabolic Alterations in Health and Disease: From Molecular Mechanisms to Biomarkers in Clinical Applications

edited by

Ramona D'Amico

and

Rosalba Siracusa

submission deadline 30 Nov 2026 | 6 articles | Viewed by 6642 | Submission Open

Keywords: metabolic syndrome; diabetes; oxidative stress; cellular metabolism; biomarkers; molecular pathways; metabolic disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Ovarian Pathologies: Insights into Mechanisms and Therapeutic Strategy

edited by Anna Ptak

submission deadline 30 Nov 2026 | 2 articles | Viewed by 6594 | Submission Open

Keywords: subfertility and infertility; hormonal dysfunction; diminished ovarian reserve (DOR); ovarian cysts; polycystic ovary syndrome (PCOS); primary ovarian insufficiency (POI); ovarian cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6477 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications

edited by Maria Rosaria Tumolo and Saverio Sabina

submission deadline 30 Nov 2026 | 7 articles | Viewed by 6281 | Submission Open

Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches

(This special issue belongs to the Section Molecular Informatics)

AI, ML and Bioinformatics in Molecular Mechanisms of Human Health and Disease

edited by

Santosh Anand

submission deadline 30 Nov 2026 | 8 articles | Viewed by 6238 | Submission Open

Keywords: artificial intelligence; machine learning; bioinformatics; molecular mechanisms; human health; human disease; multi-omics data; molecular pathways; personalized medicine; disease biomarkers

(This special issue belongs to the Section Molecular Informatics)

Toxicological Impacts of Emerging Contaminants on Aquatic Organisms

edited by

Mohamed Hamed

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6209 | Submission Open

Keywords: aquatic toxicology; emerging contaminants; physiology and behavior; oxidative stress; antioxidant biomarkers; immunotoxicity; neuroendocrine toxicity; bioremediation; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Advances in Next-Generation CRISPR and Gene Editing Tools

edited by

Oscar Pérez-Leal

submission deadline 30 Nov 2026 | 3 articles | Viewed by 6035 | Submission Open

Keywords: CRISPR engineering; miniaturized CRISPR; gene editing delivery; prime editing; base editing; epigenome editing; single-cell CRISPR

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gastrointestinal Inflammation: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Nikolett Bódi

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5950 | Submission Open

Keywords: gastrointestinal tract; inflammation; gastroenteritis; infection; microbiome; mucosal epithelium; immune cells; enteric nervous system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Insights into the Pathobiology and Biomarkers of Traumatic Brain Injury (TBI)

edited by Jessica Gill

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5825 | Submission Open

Keywords: traumatic brain injury (TBI); blood-based biomarkers; neuroinflammation; axonal injury; neurodegeneration; precision medicine; omics approaches (genomics, proteomics, metabolomics); translational neuroscience; TBI recovery and outcomes; neurovascular injury

(This special issue belongs to the Section Molecular Neurobiology)

Cardiovascular Diseases: Histopathological and Molecular Diagnostics, 2nd Edition

edited by

Simona Gurzu

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5785 | Submission Open

Keywords: cardiovascular disorders; heart failure; aortic diseases; cardiomyocytes; cardiac function; myocarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition

edited by

Livio Giuliani

Pierre Madl

and

Nikolaj Sorgenfrei Blom

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5730 | Submission Open

Keywords: quantum sciences; radiation biology; biomedical applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Insights into Lactoferrin: 2nd Edition

edited by

Antimo Cutone

and

Giovanni Musci

submission deadline 30 Nov 2026 | 4 articles | Viewed by 5709 | Submission Open

Keywords: lactoferrin; lactoferrin structure; lactoferrin functions; infection; inflammation; iron homeostasis; oxidative stress; lactoferrin bioavailability

(This special issue belongs to the Section Molecular Immunology)

Biomarker Discovery in Oral Diseases: Integrating Connected Health and Digital Biomarkers for Advanced Diagnostics and Personalized Care

edited by

Shahnawaz Khijmatgar

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5694 | Submission Open

Keywords: oral diseases; biomarker; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Molecular Insights in Women’s Health: Advances in Gynecological Disease Mechanisms and Therapeutics

edited by

Tsung-Hsuan Lai

submission deadline 30 Nov 2026 | 6 articles | Viewed by 5671 | Submission Open

Keywords: ART and IVF; prenatal diagnosis; infertility; minimally invasive surgery; robotic surgery; PCOS; endometriosis; menopause; AI

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

edited by Masahiro Terada

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5567 | Submission Open

Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity

(This special issue belongs to the Section Molecular Biology)

Neurotoxicity: Cellular Death Mechanisms in the Pathogenesis of Neurodegenerative Diseases

edited by

Mohammed Jakaria

and

Jason Cannon

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5522 | Submission Open

Keywords: neurotoxicity; cellular stress; neuronal cell death; ferroptosis; neurodegeneration; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Novel Therapeutic Strategies for Cancers

edited by

Emanuela Grassilli

and

Maria Grazia Cerrito

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5504 | Submission Open

Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Lung Research: From Mechanisms to Therapeutic Innovation

edited by

Johnatas D Silva

and Fernanda Ferreira Cruz

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5496 | Submission Open

Keywords: lung disease; molecular mechanisms; lung injury and repair; regeneration; biomarkers; therapeutic innovation; translational research; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Mechanisms in Inflammatory Bowel Disease

edited by Michael Bording-Jorgensen

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5410 | Submission Open

Keywords: IBD; cytokines; microbiome; Crohn’s disease; ulcerative colitis; dysbiosis; mucosal immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Technologies and Molecular Approaches in Brain Disease Diagnosis and Therapy

edited by

Furong Tian

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5384 | Submission Open

Keywords: neurodegenerative diseases; brain cancer; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Molecular Research on Pregnancy Complication Mechanisms

edited by

Aleksandra Stefanović

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5377 | Submission Open

Keywords: hypertensive pregnancy disorders; gestational diabetes; intrauterine growth restriction; maternal metabolism in pregnancy complications; genetic and epigenetic mechanisms in pregnancy complications; immunology in pregnancy complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Translational Research in Cardiovascular Endocrinology, Cardiovascular–Kidney–Metabolic Diseases and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): 3rd Edition

edited by

Eva Kassi

Ioannis Kyrou

and

Harpal S. Randeva

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5311 | Submission Open

Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research in Membrane Transporters, Channels, and Receptors

edited by

Ivana Vrhovac Madunic

submission deadline 30 Nov 2026 | 5 articles | Viewed by 5199 | Submission Open

Keywords: membrane transporters; cell membrane; transmembrane proteins; glucose transport; ion channels; cellular receptors; signal tranduction; pathophysiology; diabetes; aging

(This special issue belongs to the Section Molecular Biology)

Exploring Rare Diseases: Genetic, Genomic and Metabolomic Advances: 2nd Edition

edited by

Judit Bene

and

Kinga Hadzsiev

submission deadline 30 Nov 2026 | 3 articles | Viewed by 5080 | Submission Open

Keywords: rare diseases; genotype–phenotype analyses; NGS; mass spectrometry; biomarker discovery; molecular targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models

edited by Eugenio Alladio and

Elena Pilli

submission deadline 30 Nov 2026 | 2 articles | Viewed by 5019 | Submission Open

Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic and Post-Transcriptional Regulation of Gene Expression

edited by

Lidia Borkiewicz

submission deadline 30 Nov 2026 | 2 articles | Viewed by 4922 | Submission Open

Keywords: epigenome; DNA methylation; chromatin remodeling; histone modifications; non-coding RNA; epitranscriptome; alternative splicing; RNA methylation; RNA edition

(This special issue belongs to the Section Molecular Biology)

Advances in the Purinergic System

edited by

Margarete Dulce Bagatini

submission deadline 30 Nov 2026 | 5 articles | Viewed by 4762 | Submission Open

Keywords: purinergic system; receptors; ectonucleotidases; CD39; CD73; purinergic signaling

(This special issue belongs to the Section Biochemistry)

Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides

edited by