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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in 3D Tumor Models for Cancer Research

edited by

Simona Campora

Francesco Lopresti

and

Alessandra Lo Cicero

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3975 | Submission Open

Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Diabetes Research and Practice

edited by Ezekiel Uba Nwose

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3924 | Submission Open

Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Power Up Plant Genetic Research with Genomic Data: 3rd Edition

edited by

Hon-Ming Lam

Sachiko Isobe

and

Man-Wah Li

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3903 | Submission Open

Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights: Transitioning Fertility Research from the Laboratory to Clinical Practice

edited by Ekaterini Domali

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3837 | Submission Open

Keywords: IVF/ICSI; male infertility; female infertility; fertility outcomes; endocrine disruptors; oxidative and reductive stress; molecular biology; biomarkers; proteomics; metabolomics; and transcriptomics; cell lines; early pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ovarian Cancer: Pathogenesis, Biomarkers and Treatment

edited by Alessandro Antonio Buda

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3818 | Submission Open

Keywords: ovarian cancer; radiotherapy; diagnosis; prevention; treatment; fertility sparing

(This special issue belongs to the Section Molecular Oncology)

Rapeseed: Genetic Breeding, Key Trait Mining and Genome

edited by Hongbo Chao

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3789 | Submission Open

Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Arthritis: Focus on Pathologies, Symptoms and Therapy

edited by

Katarína Bauerová

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3785 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Veterinary Science

edited by

JeongWoo Kang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3701 | Submission Open

Keywords: forensic pathology and necropsy; forensic toxicology; DNA analysis in veterinary forensics; the role of veterinarians in legal investigations; case studies in veterinary forensics

(This special issue belongs to the Section Molecular Toxicology)

The Role of Mg Homeostasis in Disease: 2nd Edition

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3653 | Submission Open

Keywords: magnesium; chronic diseases; diabetes; bone disease; mineral metabolism; renal disease; inflammation; cardiovascular disease

(This special issue belongs to the Section Biochemistry)

Antiviral Strategies Targeting Capsid Proteins: Intervention from Assembly to Function

edited by

Yuqing Wu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3616 | Submission Open

Keywords: viral capsid protein; assembly modulator/intervention; virus variants; antiviral therapeutics; assembly– disassembly

(This special issue belongs to the Section Macromolecules)

Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions

edited by

Liborija Lugovic-Mihic

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3498 | Submission Open

Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Vegetable Breeding and Molecular Research

edited by

Ai-Sheng Xiong

and

Mengyao Li

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3432 | Submission Open

Keywords: vegetable breeding; gene editing; omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Innovative Research on Nutrition and Epigenetics in Cancer

edited by

Marisabel Mecca

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3354 | Submission Open

Keywords: diet; nutrition; epigenetics; cancer; cancer therapy; lifestyle

(This special issue belongs to the Section Molecular Oncology)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3316 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress and Inflammation in the Tissue Repair—Pathways and Biotechnologies

edited by Reggiani Vilela Gonçalves and Rômulo Dias Novaes

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3210 | Submission Open

Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; remodeling; molecular pathways; apoptotic alterations; diabetes; tissue repair

(This special issue belongs to the Section Biochemistry)

The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections

edited by

Maria D'Accolti

and

Elisabetta Caselli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3131 | Submission Open

Keywords: microbial infections; AMR; molecular biology; One Health; microbiome

(This special issue belongs to the Section Molecular Microbiology)

Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Yosep Chong

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3078 | Submission Open

Keywords: pathology; cytopathology; malignant effusions; biomarker; breast cancer; ovarian cancer; endometrial cancer; cervical cancer; metastasis; immunohistochemistry; immunocytochemistry; immunotherapy; genomics; proteomics; personalized medicine; prognosis and therapy; digital pathology; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Oncology)

New Insights of Autophagy and Apoptosis in Cells

edited by

Mirko Pesce

and

Antonia Patruno

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3024 | Submission Open

Keywords: autophagy; apoptosis; signal transduction; cell survival

(This special issue belongs to the Section Molecular Biology)

New Insight into Radiation Biology and Radiation Exposure

edited by Lynnette Cary

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3011 | Submission Open

Keywords: ionizing radiation; radiation biomarkers; radionuclide; medical countermeasure

(This special issue belongs to the Section Molecular Biology)

Extraction, Isolation and Identification of Natural Chemicals

edited by Jiaozhen Zhang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2981 | Submission Open

Keywords: extraction; isolation; identification; natural chemicals; biological activities

(This special issue belongs to the Section Biochemistry)

The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior

edited by

Runxiang Zhang

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2975 | Submission Open

Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact

edited by

Antonio Rescifina

and

Chiara Zagni

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2934 | Submission Open

Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products

(This special issue belongs to the Section Molecular Informatics)

Diseases in Humans and Animals: From Emergence to Translational Medicine

edited by

Pawel Kordowitzki

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2930 | Submission Open

Keywords: animal diseases; human diseases; viruses; bacteria; translational medicine; environment; zoonosis; One Health; disease models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardioprotection and Mitochondrial Signaling: Insights from Molecular Mechanisms to Therapeutic Strategies

edited by Cecilia Zazueta

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2891 | Submission Open

Keywords: cardioprotection; mitochondrial signaling; mitochondrial dysfunction; heart failure; ischemia/reperfusion; mitochondria; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition

edited by Xiaogang Li

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2885 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Drug Delivery Systems in Veterinary Medicine: Innovations and Applications

edited by

Hualin Fu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2772 | Submission Open

Keywords: design of novel veterinary drug delivery systems; methods of preparing a veterinary drug delivery system; mechanisms of action of veterinary drug delivery systems; impact of veterinary drug delivery systems on in vivo processes of veterinary drugs; clinical evaluation of veterinary drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition

edited by

Andreas Beineke

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2768 | Submission Open

Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrating Molecular Insights on Plant Microbes and Insect Pests

edited by

Xifeng Wang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2760 | Submission Open

Keywords: pathogenic microbes; resistance mechanisms; signaling pathways; omics technologies; plant and insect interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Future Perspectives and Challenges in Molecular Research of Glioma

edited by Shanchun Guo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2743 | Submission Open

Keywords: gliomas; genetic and epigenetic changes; molecular mechanisms; immunotherapy; innovative therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites

edited by

Anna Petruczynik

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2709 | Submission Open

Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques

(This special issue belongs to the Section Molecular Pharmacology)

New Insights into the Molecular Mechanisms of the UPR and Cell Stress

edited by

Quang Duy Trinh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2671 | Submission Open

Keywords: unfolded protein response; ER stress; oxidative stress; mitochondrial dysfunction; cell stress; stress response; UPR signaling pathway; immunity; inflammation; infection

(This special issue belongs to the Section Molecular Biology)

Cell Cycle-Related Proteins: Biochemical Regulative/Deregulative Mechanisms

edited by

Emanuela Stampone

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2663 | Submission Open

Keywords: cell cycle; cell division; cyclins; cyclin-dependent kinases (CDKs); biochemical regulative mechanisms

(This special issue belongs to the Section Biochemistry)

New Advances in Radiopharmaceuticals and Radiotherapy

edited by Feifei An

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2657 | Submission Open

Keywords: positron emission tomography; single photon emission computed tomography; boron neutron capture therapy; alfa-particle; radiopharmaceutical; radiotherapy; radiosensitizer; Cu-67; Lu-177; I-131; Ac-225; Pb-212; At-211

(This special issue belongs to the Section Molecular Pharmacology)

DNA Virus Infection: HPV-Related Cancers, Pathology, Biomarkers and Immunotherapy

edited by

Dimitris Tsakogiannis

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2632 | Submission Open

Keywords: HPV; molecular diagnostics; HPV ctDNA; cancer; mutations; viral oncogenicity; immunotherapy; biomarkers; oncology; cancer treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Thyroid Hormone in Health and Disease

edited by Sandra Incerpi and Jens Z. Pedersen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2599 | Submission Open

Keywords: nongenomic effects; integrin α vβ 3; crosstalk; signal transduction; metabolites; 3; 5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress; stilbene derivatives

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Benchmarking of Modeling and Informatic Methods in Molecular Sciences

edited by Abby Parrill

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2589 | Submission Open

Keywords: modeling; informatics; simulation; benchmarking; performance comparison; modeling method evaluation; informatic method evaluation

(This special issue belongs to the Section Molecular Informatics)

Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics

edited by Clinton B. Mathias and Michiko K. Oyoshi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2555 | Submission Open

Keywords: food allergy; allergic mechanisms; asthma; allergic disease; mast cells; ILC2s; Th2 cells; eosinophils; IL-4; IL-33; IL-13

(This special issue belongs to the Section Molecular Immunology)

Host-Virus Interaction

edited by

Xiaohui Ju

and

Xupeng Hong

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2538 | Submission Open

Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies

(This special issue belongs to the Section Molecular Immunology)

Pregnancy-Related Complications: From Pathogenesis to Treatment

edited by

Ozlem Guzeloglu-Kayisli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2430 | Submission Open

Keywords: adverse pregnancy outcomes; spontaneous preterm birth; idiopathic preterm birth; preeclampsia; fetal growth restriction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Challenges in Molecularly Imprinted Materials

edited by

Monika Sobiech

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2370 | Submission Open

Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization

(This special issue belongs to the Section Materials Science)

Naturally Occurring Bioactive Compounds, Neuroinflammation and Cognitive Dysfunction: Molecular and Biochemical Mechanisms

edited by

Tosin Olasehinde

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2366 | Submission Open

Keywords: neuroinflammation; cognitive dysfunction; medicinal plants; bioactive compounds; neurodegenerative diseases; molecular mechanisms; anti-inflammatory

(This special issue belongs to the Section Molecular Toxicology)

Imaging Molecules in Biomedical Research

edited by

Manuela Malatesta

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2329 | Submission Open

Keywords: biomedicine; histochemistry; immunohistochemistry; in situ hybridization; magnetic resonance imaging; optical imaging; photoacoustic imaging; ultrasound imaging; Raman microscopy

(This special issue belongs to the Section Biochemistry)

Osteoarthritis: From Pathophysiology to Novel Therapy

edited by

Paloma Guillem-Llobat

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2295 | Submission Open

Keywords: osteoarthritis; therapeutic targets; molecular mechanisms; biomarkers; bone degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics and Breeding for Sugar Crops

edited by Muqing Zhang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2258 | Submission Open

Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene

(This special issue belongs to the Section Molecular Plant Sciences)

Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases

edited by

Takuro Miyazaki

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2255 | Submission Open

Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Depression—2nd Edition

edited by

Magdalena Sowa-Kućma

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2249 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2243 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

edited by

Jianqiang Xu

and

Yanshuo Han

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2216 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Rhizobia

edited by