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Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 28 June 2025 | Viewed by 487

Special Issue Editors


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Guest Editor
School of Chemical Engineering, Ocean Technology and Life Science, Dalian University of Technology, Panjin 124221, China
Interests: vascular biology; abdominal aortic aneurysm; aortic dissection; vascular inflammation; endothelial dysfunction; bioinformatics

Special Issue Information

Dear Colleagues,

Chronic diseases such as cardiovascular disorders, cancer, neurodegenerative diseases, and metabolic syndromes often stem from the interplay between oxidative stress and inflammation. Oxidative stress arises from an imbalance between the reactive oxygen species (ROS) production and antioxidant defenses, leading to cellular damage. Concurrently, inflammation is a critical biological response to harmful stimuli; however, dysregulated or chronic inflammation can perpetuate tissue injury and disease progression. Together, these processes form a vicious cycle that exacerbates pathophysiological conditions. Natural bioactive compounds derived from plants and other natural sources have gained significant attention for their dual roles as antioxidants and anti-inflammatory agents. These compounds not only mitigate oxidative damage by modulating redox homeostasis but also target key inflammatory pathways, offering a multifaceted approach to disease prevention and treatment. Importantly, their structural diversity, wide range of molecular targets, and relatively low toxicity, make them promising candidates for drug discovery and therapeutic development. This Special Issue aims to explore the mechanistic insights, therapeutic potential, and applications of natural bioactive compounds in modulating inflammation and oxidative stress. We welcome original research and review articles focusing on the discovery of novel compounds, elucidation of their mechanisms of action, and their roles in disease management, including applications in chemotherapy, immunotherapy, and cell fate regulation. Studies integrating natural compounds into combination therapies and addressing synergistic effects are particularly encouraged.

Dr. Jianqiang Xu
Dr. Yanshuo Han
Guest Editors

Manuscript Submission Information

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Keywords

  • oxidative stress
  • inflammation
  • chronic diseases
  • natural bioactive compounds
  • plant-derived molecules
  • redox homeostasis
  • anti-inflammatory mechanisms
  • antioxidant activity
  • drug discovery
  • synergistic effects
  • combination therapies

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Published Papers (1 paper)

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Research

14 pages, 3177 KiB  
Article
Flow Cytometry-Based Rapid Assay for Antigen Specific Antibody Relative Affinity in SRBC-Immunized Mouse Models
by Chunli Sun, Yuan Jiang, Shujun Liu, Qilin He, Chengyao Han, Dai Su, Hao Ma, Xingyu Guo, Yan Zhang, Fubin Li and Huihui Zhang
Int. J. Mol. Sci. 2025, 26(8), 3664; https://doi.org/10.3390/ijms26083664 - 12 Apr 2025
Viewed by 299
Abstract
Sheep red blood cells (SRBC) has a long history as a classical T-cell dependent (TD) antigen. Due to its cost-effectiveness, easy accessibility, and ability to elicit a robust antibody immune response, SRBC continues to be widely used in studies related with humoral immunity [...] Read more.
Sheep red blood cells (SRBC) has a long history as a classical T-cell dependent (TD) antigen. Due to its cost-effectiveness, easy accessibility, and ability to elicit a robust antibody immune response, SRBC continues to be widely used in studies related with humoral immunity modulation, vaccine development, and immunoactivity/immunotoxicity testing of bioactive agents. However, detecting the relative affinity levels of SRBC-specific antibodies in SRBC-immunized animal models remains challenging. Using flow cytometry, we established a detection system capable of quickly and accurately assessing the SRBC-specific antibody relative affinity levels in humoral samples (e.g., serum, tissue fluid) of SRBC-immunized mouse models. We further validated this method using affinity maturation-deficient mice, demonstrating that this method can distinguish affinity levels of the antibodies from different samples. This approach is simple and efficient, providing an accurate and effective technological solution for research on mechanisms of humoral immunity, antibody affinity maturation, vaccine response, and immunoactivity/immunotoxicity testing. Full article
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