The Role of Thyroid Hormone in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 1998
Special Issue Editors
Interests: nongenomic effects; integrin αvβ3; crosstalk between genomic and nongenomic effects; signal transduction; metabolites; 3,5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress
Interests: free radical biochemistry; metalloproteins; studies on metals in biological systems; EPR spectroscopy
Special Issue Information
Dear Colleagues,
Thyroid hormones act on classical nuclear or cytosolic receptors, modulating development, growth and metabolism.
In 2005, the discovery of integrin αvβ3 being a mediator of fast nongenomic effects has given new inputs into the knowledge of these ‘old’ hormones. In particular, the binding of T4 to integrin αvβ3 gives rise to proliferation and angiogenesis in tumor cells, stimulating research on the development of inhibitors of tumor cell growth as possible pharmacological tools to fight cancer.
The finding that thyroid hormones have a binding site on integrin αvβ3, representing the ‘door’ for bacteria and virus to enter cells has brought new knowledge on the relationship between thyroid hormones and the immune system.
We are looking forward to the possible contributions on the crosstalk between the genomic and nongenomic effects of thyroid hormones.
Dr. Sandra Incerpi
Dr. Jens Z. Pedersen
Guest Editors
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Keywords
- nongenomic effects
- integrin αvβ3
- crosstalk
- signal transduction
- metabolites
- 3,5-diiodothyronine
- tetraiodothyrocetic acid (tetrac)
- antioxidant
- oxidative stress
- stilbene derivatives
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