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Diseases in Humans and Animals: From Emergence to Translational Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1611

Special Issue Editor


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Guest Editor
Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
Interests: oocyte aging; telomeres; mitochondria; DNA-methylation; zoonotic diseases
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Special Issue Information

Dear Colleagues,

Zoonotic diseases, which are infections that can be transmitted from animals to humans, have long been a subject of significant concern in the realm of public health. These diseases not only pose a threat to human health, but also have significant implications for animal welfare and the overall ecosystem. The importance of wildlife as a reservoir for zoonotic infections has been increasingly recognized, with hundreds of pathogens and diverse transmission modes involved. The emergence and re-emergence of zoonotic diseases are driven by a complex interplay of factors, including growing populations, globalization, urbanization, and the interaction of the environment with humans and livestock. Zoonotic diseases can cause a substantial burden of disease, with endemic and enzootic zoonoses responsible for about a billion cases of illness in people and millions of deaths every year. To address the challenge of zoonotic diseases, the "One Health" approach has gained prominence, emphasizing the need for a multidisciplinary, holistic perspective that integrates human, animal, and environmental health. Translational medicine, a rapidly evolving field, aims at transforming scientific discoveries into meaningful clinical applications. This research paradigm has gained significant attention in the context of personalized medicine, where the ultimate goal is to develop targeted therapies and interventions tailored to an individual's unique genetic and molecular profile.

Dr. Pawel Kordowitzki
Guest Editor

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Keywords

  • animal diseases
  • human diseases
  • viruses
  • bacteria
  • translational medicine
  • environment
  • zoonosis
  • One Health
  • disease models

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Published Papers (1 paper)

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Review

11 pages, 1000 KiB  
Review
Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging
by Pawel Kordowitzki
Int. J. Mol. Sci. 2024, 25(24), 13318; https://doi.org/10.3390/ijms252413318 - 12 Dec 2024
Viewed by 1310
Abstract
Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause a severe and often fatal illness. The zoonotic EEEV enzootic cycle involves a cycle of transmission between Culiseta melanura and avian hosts, frequently resulting in spillover to dead-end vertebrate [...] Read more.
Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that, among humans, can cause a severe and often fatal illness. The zoonotic EEEV enzootic cycle involves a cycle of transmission between Culiseta melanura and avian hosts, frequently resulting in spillover to dead-end vertebrate hosts such as humans and horses. Interestingly, it has been described that the W132G mutation of the very low-density lipoprotein receptor (VLDLR), the receptor of EEEV, significantly enhanced the VLDLR-mediated cell attachment of EEEV. The patient’s metabolism plays a pivotal role in shaping the complex landscape of viral zoonosis. EEEV represents a significant public health concern due to its severe clinical outcomes, challenging epidemiological characteristics, and certain risk factors that heighten susceptibility among specific populations or age groups. Age is one of several predictors that can impact the outcome of EEEV infection; juvenile animals appear to be particularly vulnerable to severe disease. This has also been observed in natural infections, as children are often the most severely impacted humans. The aim of this piece is to shed light on the intricate relationship between human metabolism and the Eastern equine encephalitis virus. Full article
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