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The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 1560

Special Issue Editor

Prof. Dr. Runxiang Zhang

E-Mail Website
Guest Editor
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
Interests: laying hens; stress; animal welfare; animal behavior; neurophysiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolism-related pathways, such as lipid metabolism pathway, insulin signaling pathway, and AMP-activated protein kinase pathway, are currently in the spotlight due to their broad impact on animal growth, development, energy balance, and behavior, all of which occur through a complex network of interactions. In-depth studies of the molecular mechanisms and intrinsic connections of these metabolic pathways will enhance our understanding of their critical roles in animal growth, development, and behavior.

In light of this, led by Prof. Runxiang Zhang, and assisted by Dr. Hui Yuan (Northeast Agricultural University), the objective of this Special Issue is to collect reports on the role of metabolism-related pathways in animal growth, development, disease, and behavior. We invite researchers to submit original research articles, opinion papers, reviews, and short communications that present current findings and future directions related to metabolism-related pathways. We look forward to receiving your valuable submissions.

Prof. Dr. Runxiang Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolism pathway
  • signal pathway
  • animal development
  • animal behavior
  • animal disease

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Published Papers (2 papers)

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Research

14 pages, 3089 KB  
Article
Breed Varieties of Pigs for Disease Resistance and Susceptibility to Seneca Valley Virus Infection
by Wentao Wang, Fengze Han, Xinmiao He, Shihan Zhao, Ziluo Zou, Ming Tian, Heshu Chen, Saihui Wu, Yan Sun, Yaokun Jiang, Meiqin Sun, Libing Zhang, Kunzhi Yu, Yao Wang, Yaguang Tian, Xinpeng Jiang and Di Liu
Int. J. Mol. Sci. 2025, 26(17), 8746; https://doi.org/10.3390/ijms26178746 - 8 Sep 2025
Viewed by 588
Abstract
In recent years, outbreaks of Seneca Valley virus (SVV) in pig farms have raised concerns about disease resistance in different pig breeds. Min pigs are an excellent local pig breed in China, but the breed’s strong disease resistance mechanism has not been clearly [...] Read more.
In recent years, outbreaks of Seneca Valley virus (SVV) in pig farms have raised concerns about disease resistance in different pig breeds. Min pigs are an excellent local pig breed in China, but the breed’s strong disease resistance mechanism has not been clearly investigated. In this study, Min pigs and Landrace pigs were challenged with SVV, and the differences in pathogenicity between SVV-infected Min and Landrace pigs were evaluated in terms of production performance, survival rate, immune cell activity, pathological changes, viral titer, and cytokine expression. The results show that the mortality rate in Min pigs was significantly lower than that in Landrace pigs without substantial weight loss. The copy number of SVV RNA in the intestinal mucosa of Min pigs was lower than that in Landrace pigs. Additionally, the IgA and IgG titers in Min pigs were higher than those in Landrace pigs. Both the absolute number and percentage of M1 macrophages were elevated in Min pigs relative to Landrace pigs. This study is the first to identify differences in macrophage activity between SVV-infected Min pigs and Landrace pigs. The presented results indicate the potential research value of studying innate immunity differences in disease resistance between pig breeds. Full article
(This article belongs to the Special Issue The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior)
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13 pages, 794 KB  
Communication
Preparturient Oral Selenitetriglycerides Supplementation Elevates Erythrocyte Glutathione Peroxidase Activity and Modulates Hepatic TNF-α, PPAR-α, and PPAR-δ mRNA in Postparturient Holstein–Friesian Cows
by Katarzyna Żarczyńska, Katarzyna Różańska, Paweł Brym and Dawid Tobolski
Int. J. Mol. Sci. 2025, 26(16), 8018; https://doi.org/10.3390/ijms26168018 - 19 Aug 2025
Viewed by 455
Abstract
The transition period in dairy cows, spanning late pregnancy and early lactation, is associated with substantial metabolic and immunological challenges, leading to increased oxidative stress and inflammation. Selenium (Se), particularly in organic forms, supports antioxidant defenses, immune function, and metabolic regulation. This study [...] Read more.
The transition period in dairy cows, spanning late pregnancy and early lactation, is associated with substantial metabolic and immunological challenges, leading to increased oxidative stress and inflammation. Selenium (Se), particularly in organic forms, supports antioxidant defenses, immune function, and metabolic regulation. This study investigated the effects of supplementing periparturient Holstein–Friesian cows with orally administered selenitetriglycerides (0.5 mg Se/kg body weight/day starting 12 days before the expected calving date and continuing until parturition) on antioxidant enzyme activity and on the hepatic expression of key inflammatory and metabolic genes. Serum selenium concentrations and erythrocyte glutathione peroxidase (GSH-Px) activity were assessed before and after parturition, and hepatic gene expression levels of tumor necrosis factor alpha (TNF-α), peroxisome proliferator-activated receptor alpha (PPAR-α) and delta (PPAR-δ) were assessed 24 h and 7 days postpartum. Supplemented cows showed significantly elevated serum Se levels and increased GSH-Px activity, reflecting improved antioxidant capacity. Moreover, hepatic expression of TNF-α and PPAR-δ was significantly reduced postpartum in the supplemented group, whereas PPAR-α expression remained stable. These findings indicate that selenitetriglycerides effectively enhance antioxidant defenses, moderate inflammation, and stabilize metabolic pathways during the periparturient phase, potentially reducing postpartum metabolic disorders and improving dairy-cow health. Full article
(This article belongs to the Special Issue The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior)
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