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Extraction, Isolation and Identification of Natural Chemicals

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1088

Special Issue Editor


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Guest Editor
Key Laboratory of Chemical Biology of Natural Products (Ministry of Education), School of Pharmaceutical Sciences, College of Medicine, Shandong University, Jinan 250012, China
Interests: phytochemistry; diterpenoids; anti-inflammatory activity; Tibetan medicine; liverworts; mass spectrometry; mass spectrometry imaging

Special Issue Information

Dear Colleagues,

Natural products are a huge gift from nature to scientists, serving as an important source for drug discovery. Given that approximately 60% of drugs are derived directly or indirectly from natural products, it is crucial to delve into the extraction, isolation, and identification of these natural chemicals. The aim of this Special Issue is to focus on original research and review articles that cover advancements in the extraction, isolation, and characterization of natural chemicals. This includes the development of new methodologies for the extraction and purification of natural compounds, the identification of novel chemical structures, and the elucidation of their potential biological activities. In addition, as IJMS is a journal of molecular science, pure clinical studies will not be suitable for our journal and this Special Issue.

Dr. Jiaozhen Zhang
Guest Editor

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Keywords

  • extraction
  • isolation
  • identification
  • natural chemicals
  • biological activities

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Published Papers (1 paper)

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Research

13 pages, 3552 KiB  
Article
Biological Activities of Constituents from Rosa roxburghii and Their Mechanisms Based on Network Pharmacology and Biological Verification
by Li-Juan Xiang, Shuang Zhang, Ming-Liang Luo, Xing-Xiang Long, Ying Zhou and Xin Yin
Int. J. Mol. Sci. 2025, 26(3), 1353; https://doi.org/10.3390/ijms26031353 - 5 Feb 2025
Viewed by 898
Abstract
Rosa roxburghii Tratt is widely cultivated in southwestern areas of China for a range of purposes, including food and medicine. To enhance its application value, one previously undescribed compound (1) and six known compounds (27) were isolated [...] Read more.
Rosa roxburghii Tratt is widely cultivated in southwestern areas of China for a range of purposes, including food and medicine. To enhance its application value, one previously undescribed compound (1) and six known compounds (27) were isolated from the roots of R. roxburghii. The structures of compounds (17) were determined through NMR, HR-MS, and CD experiments, and by comparison of their spectroscopic data with values from the literature. Roxbubenzoate A (1) contained a benzoyl glucuronosyl glycerol scaffold featuring a rare α-glucuronosyl linkage. Seven compounds (17) were tested for their anti-inflammatory, α-glucosidase-inhibitory, and radical-scavenging activities. Compound 3 showed a significant inhibitory effect on the release of NO in LPS-induced RAW264.7 macrophages, with an IC50 value of 7.8 ± 0.2 μM. Compounds 2, 4, and 7 exhibited moderate inhibitory activity against α-glucosidase, with inhibition rates of 50.1%, 46.7%, and 41.1% at a concentration of 200 μM, respectively. Compounds 1, 2, and 6 exhibited moderate ABTS radical-scavenging activity, with IC50 values of 107.0 ± 1.1, 142.6 ± 0.8, and 128.3 ± 1.2 μM, respectively. The network pharmacological analysis and molecular docking results suggested that 3 may be able to treat inflammation by binding TNF-α and IL-6 targets. Finally, the expression of IL-6 and TNF-α in LPS-induced RAW264.7 macrophages was detected through ELISA, and 3 showed a strong inhibitory effect on IL-6 release. These findings offer a novel perspective on the development of rich medicinal plant resources from R. roxburghii roots. Full article
(This article belongs to the Special Issue Extraction, Isolation and Identification of Natural Chemicals)
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