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New Advances in Radiopharmaceuticals and Radiotherapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1494

Special Issue Editor


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Guest Editor
School of Public Health, Health Science Center, Xi’an Jiaotong University, No.76 Yanta West Road, Xi’an 710061, China
Interests: radiopharmaceuticals; radiotherapy

Special Issue Information

Dear Colleagues,

Radiopharmaceuticals and radiotherapy are not new terms in the medical field. However, these areas have gained increasing attention due to advancements in scanning technologies for targeted antibodies, peptides, and small molecules over the past two decades. These developments have opened up opportunities for creating targeted radiopharmaceuticals for precise radiotherapy. This special issue focuses on recent progress in radiopharmaceuticals and radiotherapy. Welcome research from the molecular designs, mechanisms of radiopharmaceuticals and radiotherapy, as well as research from fields such as positron emission tomography (PET), single photon emission computed tomography (SPECT), Boron Neutron Capture Therapy (BNCT), and radiosensitizers, including those based on 67Cu, 177Lu, 131I, 225Ac, 212Pb and 211At. The combinations of abovementioned fileds are extremely attractive. We also encourage submissions on other radiopharmaceuticals and radiotherapy for this special issue.

Dr. Feifei An
Guest Editor

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Keywords

  • positron emission tomography
  • single photon emission computed tomography
  • boron neutron capture therapy
  • alfa-particle
  • radiopharmaceutical
  • radiotherapy
  • radiosensitizer
  • Cu-67
  • Lu-177
  • I-131
  • Ac-225
  • Pb-212
  • At-211
 

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Published Papers (1 paper)

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Research

20 pages, 4594 KiB  
Article
Synthesis of New Promising BNCT Agents Based on Conjugates of closo-Dodecaborate Anion and Aliphatic Diamino Acids
by Margarita N. Ryabchikova, Alexey V. Nelyubin, Ilya N. Klyukin, Nikita A. Selivanov, Alexander Yu. Bykov, Alexey S. Kubasov, Vsevolod A. Skribitsky, Yulia A. Finogenova, Kristina E. Shpakova, Anton A. Kasianov, Alexey A. Lipengolts, Andrey P. Zhdanov, Elena Yu. Grigoreva, Konstantin Yu. Zhizhin and Nikolay T. Kuznetsov
Int. J. Mol. Sci. 2025, 26(1), 68; https://doi.org/10.3390/ijms26010068 - 25 Dec 2024
Cited by 1 | Viewed by 1141
Abstract
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an amino group in the side chain of the general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where [...] Read more.
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an amino group in the side chain of the general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino and α-carboxyl groups recognized by the binding centers of the large neutral amino acid transporter (LAT) system, which serves as a target for the clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several approaches to synthesizing the target compounds, their acute toxicity studies, and tumor uptake studies in vivo in two tumor models. The promising compound [B12H11NHC(NH(CH2)2CH(NH3)COOH)CH3]*3H2O demonstrates low toxicity (LD50 in a range from 150 to 300 mg/kg) and excellent solubility and also shows selective uptake in experimental melanoma in laboratory mice (T/N ratio remained >3 up to 60 min post-injection, with a maximum T/N of 6.2 ± 2.8 at 45 min). Full article
(This article belongs to the Special Issue New Advances in Radiopharmaceuticals and Radiotherapy)
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