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New Advances in Radiopharmaceuticals and Radiotherapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (20 December 2025) | Viewed by 4881

Special Issue Editor


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Guest Editor
School of Public Health, Health Science Center, Xi’an Jiaotong University, No.76 Yanta West Road, Xi’an 710061, China
Interests: radiopharmaceuticals; radiotherapy

Special Issue Information

Dear Colleagues,

Radiopharmaceuticals and radiotherapy are not new terms in the medical field. However, these areas have gained increasing attention due to advancements in scanning technologies for targeted antibodies, peptides, and small molecules over the past two decades. These developments have opened up opportunities for creating targeted radiopharmaceuticals for precise radiotherapy. This special issue focuses on recent progress in radiopharmaceuticals and radiotherapy. Welcome research from the molecular designs, mechanisms of radiopharmaceuticals and radiotherapy, as well as research from fields such as positron emission tomography (PET), single photon emission computed tomography (SPECT), Boron Neutron Capture Therapy (BNCT), and radiosensitizers, including those based on 67Cu, 177Lu, 131I, 225Ac, 212Pb and 211At. The combinations of abovementioned fileds are extremely attractive. We also encourage submissions on other radiopharmaceuticals and radiotherapy for this special issue.

Dr. Feifei An
Guest Editor

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Keywords

  • positron emission tomography
  • single photon emission computed tomography
  • boron neutron capture therapy
  • alfa-particle
  • radiopharmaceutical
  • radiotherapy
  • radiosensitizer
  • Cu-67
  • Lu-177
  • I-131
  • Ac-225
  • Pb-212
  • At-211
 

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Published Papers (2 papers)

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Research

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20 pages, 4594 KB  
Article
Synthesis of New Promising BNCT Agents Based on Conjugates of closo-Dodecaborate Anion and Aliphatic Diamino Acids
by Margarita N. Ryabchikova, Alexey V. Nelyubin, Ilya N. Klyukin, Nikita A. Selivanov, Alexander Yu. Bykov, Alexey S. Kubasov, Vsevolod A. Skribitsky, Yulia A. Finogenova, Kristina E. Shpakova, Anton A. Kasianov, Alexey A. Lipengolts, Andrey P. Zhdanov, Elena Yu. Grigoreva, Konstantin Yu. Zhizhin and Nikolay T. Kuznetsov
Int. J. Mol. Sci. 2025, 26(1), 68; https://doi.org/10.3390/ijms26010068 - 25 Dec 2024
Cited by 7 | Viewed by 2815
Abstract
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an amino group in the side chain of the general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where [...] Read more.
In this work, a series of boronated amidines based on the closo-dodecaborate anion and amino acids containing an amino group in the side chain of the general formula [B12H11NHC(NH(CH2)nCH(NH3)COOH)CH3], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino and α-carboxyl groups recognized by the binding centers of the large neutral amino acid transporter (LAT) system, which serves as a target for the clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several approaches to synthesizing the target compounds, their acute toxicity studies, and tumor uptake studies in vivo in two tumor models. The promising compound [B12H11NHC(NH(CH2)2CH(NH3)COOH)CH3]*3H2O demonstrates low toxicity (LD50 in a range from 150 to 300 mg/kg) and excellent solubility and also shows selective uptake in experimental melanoma in laboratory mice (T/N ratio remained >3 up to 60 min post-injection, with a maximum T/N of 6.2 ± 2.8 at 45 min). Full article
(This article belongs to the Special Issue New Advances in Radiopharmaceuticals and Radiotherapy)
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Review

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41 pages, 1227 KB  
Review
Lanthanide Nanotheranostics in Radiotherapy
by Shaofeng Han, Yurun Liu, Taoyang Cai, Yanru Liu and Shangjie Ge-Zhang
Int. J. Mol. Sci. 2026, 27(1), 426; https://doi.org/10.3390/ijms27010426 - 31 Dec 2025
Viewed by 1262
Abstract
Radiotherapy, a cornerstone of cancer treatment, is critically limited by tumor radioresistance and off-target toxicity. Lanthanide-based nanomaterials (Ln-NPs) have recently emerged as a versatile and promising class of theranostic radiosensitizers to overcome these hurdles. This review comprehensively outlines the state-of-the-art in Ln-NP-enabled radiotherapy, [...] Read more.
Radiotherapy, a cornerstone of cancer treatment, is critically limited by tumor radioresistance and off-target toxicity. Lanthanide-based nanomaterials (Ln-NPs) have recently emerged as a versatile and promising class of theranostic radiosensitizers to overcome these hurdles. This review comprehensively outlines the state-of-the-art in Ln-NP-enabled radiotherapy, beginning with their fundamental physicochemical properties and synthesis and then delving into the multi-level mechanisms of radiosensitization, including high-Z element-mediated physical dose amplification, catalytic generation of reactive oxygen species (ROS), and disruption of DNA damage repair pathways. The unique capacity of certain Ln-NPs to serve as MRI contrast agents is highlighted as the foundation for image-guided, dose-painting radiotherapy. We critically summarize the preclinical and clinical progress of representative systems, benchmarking them against other high-Z nanomaterials. Finally, this work discusses the ongoing challenges, such as biocompatibility, targeted delivery, and regulatory hurdles, and envisages future directions, including combinatorial strategies with immunotherapy and the development of personalized nanotheranostic paradigms. Through this synthesis, this review aims to provide a clear roadmap for the continued development and clinical integration of lanthanide nanotheranostics in oncology. Full article
(This article belongs to the Special Issue New Advances in Radiopharmaceuticals and Radiotherapy)
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