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Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1175

Special Issue Editors


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Guest Editor
Medical School, University of Cyprus, 2029 Nicosia, Cyprus
Interests: cytopathology; immunohistochemistry; cancer; systematic review and meta-analysis; medical education
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece
Interests: pathology; cancer pathology; colorectal cancer; lung cancer; pancreatic cancer; breast cancer; inflammation; infectious agents; cell cycle; metabolism
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul 06591, Republic of Korea
Interests: pathology; hematopathology; cytology; metaanalysis; digital pathology; artificial intelligence
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Special Issue Information

Dear Colleagues,

Breast and gynecologic malignancies are major causes of morbidity and mortality worldwide. To diagnose them, histopathological or cytopathological sampling is performed, and selected biomarkers related to diagnosis, prognosis, and therapy are routinely evaluated. There has been tremendous progress in the fields of breast and gynecological cancers, which is highlighted by the presence of well-defined molecular subtypes and tailored therapies. However, discovering new biomarkers would enhance the management of these patients. This Special Issue welcomes original studies, reviews, and short communications, aiming to address novel biomarkers assessed in tissue or cytological material of patients with breast or gynecologic malignancies. Large-scale studies evaluating well-established rather than candidate biomarkers or presenting negative findings are also welcome. Potential topics include the following:

  • Biomarkers tested on cytological (e.g., fine needle aspirations, malignant effusions, cervical cytology) or histopathological material;
  • Biomarkers related to diagnosis, prognosis, or therapy of patients with breast or gynecologic cancers;
  • Biomarkers assessed with immunohistochemistry or immunocytochemistry;
  • Biomarkers assessed with high-throughput molecular techniques (e.g., next-generation sequencing or mass spectrometry);
  • Biomarkers predicting response to immunotherapy;
  • Biomarkers measured with the aid of digital pathology and artificial intelligence;
  • Biomarker testing highlighting cytopathological correlation;
  • Systematic reviews and meta-analyses focusing on well-established biomarkers tested on tissue biopsy or cytology specimens.

Dr. Ilias P. Nikas
Dr. Ioannis Pateras
Prof. Dr. Yosep Chong
Guest Editors

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Keywords

  • pathology
  • cytopathology
  • malignant effusions
  • biomarker
  • breast cancer
  • ovarian cancer
  • endometrial cancer
  • cervical cancer
  • metastasis
  • immunohistochemistry
  • immunocytochemistry
  • immunotherapy
  • genomics
  • proteomics
  • personalized medicine
  • prognosis and therapy
  • digital pathology
  • artificial intelligence
  • machine learning

 

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Published Papers (1 paper)

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13 pages, 1590 KiB  
Perspective
Double–Multiplex Immunostainings for Immune Profiling of Invasive Breast Carcinoma: Emerging Novel Immune-Based Biomarkers
by Sofia D. P. Theodorou, Konstantinos Ntostoglou, Ilias P. Nikas, Dimitrios Goutas, Vassilis Georgoulias, Christos Kittas and Ioannis S. Pateras
Int. J. Mol. Sci. 2025, 26(7), 2838; https://doi.org/10.3390/ijms26072838 - 21 Mar 2025
Viewed by 432
Abstract
The role of tumor microenvironment in invasive breast cancer prognosis and treatment is highly appreciated. With the advent of immunotherapy, immunophenotypic characterization in primary tumors is gaining attention as it can improve patient stratification. Here, we discuss the benefits of spatial analysis employing [...] Read more.
The role of tumor microenvironment in invasive breast cancer prognosis and treatment is highly appreciated. With the advent of immunotherapy, immunophenotypic characterization in primary tumors is gaining attention as it can improve patient stratification. Here, we discuss the benefits of spatial analysis employing double and multiplex immunostaining, allowing the simultaneous detection of more than one protein on the same tissue section, which in turn helps us provide functional insight into infiltrating immune cells within tumors. We focus on studies demonstrating the prognostic and predictive impact of distinct tumor-infiltrating lymphocyte subpopulations including different CD8(+) T subsets as well as CD4(+) T cells and tumor-associated macrophages in invasive breast carcinoma. The clinical value of immune cell topography is also appreciated. We further refer to how the integration of digital pathology and artificial intelligence in routine practice could enhance the accuracy of multiplex immunostainings evaluation within the tumor microenvironment, maximizing our perception of host immune response, improving in turn decision-making towards more precise immune-associated therapies. Full article
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