Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 398
Special Issue Editors
Interests: mast cells; food allergy; allergic diseases
Special Issue Information
Dear Colleagues,
Allergic Diseases such as food allergy and allergic asthma are a growing public health concern, affecting one-third of the American population and on the rise in urban areas globally. Recent research has uncovered various endogenous and environmental factors that contribute to the development of allergic disease, including genetic variations, epigenetic modifications, immune dysregulation, dietary components, the gut microbiome, and dietary patterns and habits. These factors not only regulate the intensity of allergic sensitization but also amplify the immune response to harmless, innocuous environmental allergens. Moreover, groundbreaking discoveries in immune cell mechanisms and functions have significantly advanced our understanding of allergy pathogenesis, shedding light on the roles of various cells and proteins, such as T and B cells, mast cells, group 2 innate lymphoid cells, and eosinophils, as well as cytokines like IL-33, IL-25, TSLP, and IL-4 and IL-13. These findings have paved the way for the development of novel therapeutic approaches that target these pathways and mediators.
In this issue, we are delighted to welcome original research and review articles that further enrich the existing literature on the mechanisms underlying the pathogenesis of allergic diseases and the development of therapeutic approaches.
Dr. Clinton B. Mathias
Dr. Michiko K. Oyoshi
Guest Editors
Manuscript Submission Information
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Keywords
- food allergy
- allergic mechanisms
- asthma
- allergic disease
- mast cells
- ILC2s
- Th2 cells
- eosinophils
- IL-4
- IL-33
- IL-13
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