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Imaging Molecules in Biomedical Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 1039

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Special Issue Information

Dear Colleagues,

This Special Issue focuses on the application in vitro, ex vivo and in vivo of techniques for a molecular analysis in situ. Histochemistry and immunohistochemistry at light and electron microscopy, in situ hybridization, magnetic resonance imaging, optical imaging, photoacoustic imaging, ultrasound imaging, Raman microscopy enable the detection, characterization and quantification of biological markers and molecular pathways directly in the cytological/histological/anatomical context where they occur, thus bridging the gap between molecular and structural approaches. This is important in biomedical research since the presence, quantity or ectopic location of specific molecules may be crucial for detecting changes in tissue or cell function under physiological or pathological conditions.

We encourage the submission of original research articles or reviews on the application of these techniques to investigate pathological and physiological processes or to evaluate the efficacy of new therapeutic approaches. Methodological studies establishing novel techniques for imaging molecules in situ are also welcome.

Dr. Manuela Malatesta
Guest Editor

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Keywords

  • biomedicine
  • histochemistry
  • immunohistochemistry
  • in situ hybridization
  • magnetic resonance imaging
  • optical imaging
  • photoacoustic imaging
  • ultrasound imaging
  • Raman microscopy

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Published Papers (1 paper)

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Review

24 pages, 393 KiB  
Review
Aging in the Skeletal Muscle Revealed by Molecular Immunohistochemical Imaging
by Manuela Malatesta and Barbara Cisterna
Int. J. Mol. Sci. 2025, 26(13), 5986; https://doi.org/10.3390/ijms26135986 - 22 Jun 2025
Viewed by 802
Abstract
The skeletal muscle is a complex organ mainly composed of multinucleated fibres responsible for contractile activity, but it also contains postnatal myogenic stem cells (i.e., satellite cells), connective cells and nervous cells. The skeletal muscle is severely affected by aging, undergoing a progressive [...] Read more.
The skeletal muscle is a complex organ mainly composed of multinucleated fibres responsible for contractile activity, but it also contains postnatal myogenic stem cells (i.e., satellite cells), connective cells and nervous cells. The skeletal muscle is severely affected by aging, undergoing a progressive reduction in muscle mass, strength and endurance in a condition known as sarcopenia. The mechanisms underlying sarcopenia still need to be completely clarified, but they are undoubtedly multifactorial, involving all cell types constituting the skeletal muscle. Immunohistochemistry has widely been used to investigate skeletal muscle aging, identifying age-related molecular alterations in the various myofibre components, as well as in the satellite cells and peri-fibre environment. The wide range of immunohistochemical data reported in this review is proof of the primary role played by this long-established, yet modern, technique. Its high specificity for the molecules of interest, and the possibility of imaging and quantifying the signal in the real histological or cytological sites where these molecules are located and active, makes immunohistochemistry a unique and irreplaceable tool among the laboratory techniques in biomedicine. Full article
(This article belongs to the Special Issue Imaging Molecules in Biomedical Research)
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