DNA Virus Infection: HPV-Related Cancers, Pathology, Biomarkers and Immunotherapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 443
Special Issue Editor
Interests: molecular virology; oncogenic viruses; HPV; biomarkers; virus–host interactions; viral evolution
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human Papillomavirus (HPV) is a widespread viral infection that is associated with several types of cancer. This infection is responsible for more than 5% of global cancer incidences, affecting both women and men. According to their tumorigenic capacity, Alpha HPV genotypes are classified into low-risk (LR-HPVs) and high-risk (HR-HPVs) HPVs. Long-term HR-HPV infection is the leading cause of cervical cancer development, and it is implicated in the progression of other malignancies, including vulvar, vaginal, anal, penile, and oropharyngeal. Moreover, Beta HPVs are involved in the development of skin tumors. HPVs have developed various mechanisms to promote their genome replication by modulating the cell cycle, and they have evolved several strategies to avoid host immune response, cellular senescence, and apoptosis. Thus, HPV infection causes chromosomal damage and genetic changes that eventually result in tumor growth. Nowadays, the treatment of HPV-related cancers remains a challenging aspect. Immunotherapy has become a pillar of cancer care, improving the prognosis of many patients with solid tumors. Advances in cancer immunotherapy and tumor immunology are contributing to the development of innovative immunotherapeutic approaches for treating HPV-associated cancers. Several strategies have been evaluated, containing therapeutic HPV vaccines, adoptive cell transfer (ACTs), and immune checkpoint blockades.
The aim of this Special Issue is to better understand the molecular mechanisms involved in HPV-induced tumorigenicity as well as to assess the impact of immunotherapy on HPV-related cancers. We welcome submissions of research articles and reviews focused on the following potential topics (but are not limited to): molecular mechanisms of HPV-associated cancers, molecular diagnostic methods, genetic changes in viral and host DNA, novel biomarkers, HPV circulating tumor DNA, therapeutic vaccines, and new immunotherapeutic strategies for HPV-driven cancers in order to meet expert views, the state of the art, and recent advancements in the field of viral oncology.
I look forward to receiving your contributions.
Dr. Dimitris Tsakogiannis
Guest Editor
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Keywords
- HPV
- molecular diagnostics
- HPV ctDNA
- cancer
- mutations
- viral oncogenicity
- immunotherapy
- biomarkers
- oncology
- cancer treatment
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