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Molecular and Serological Tests for COVID-19. A Comparative Review of SARS-CoV-2 Coronavirus Laboratory and Point-of-Care Diagnostics

COVID-19 Serological Tests: How Well Do They Actually Perform?

Novateur Ventures Inc., Vancouver, BC V6E 3P3, Canada
Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada
NSF Health Sciences, Kirkbymoorside, York YO62 6AF, UK
Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(7), 453;
Received: 14 June 2020 / Revised: 30 June 2020 / Accepted: 1 July 2020 / Published: 4 July 2020
In only a few months after initial discovery in Wuhan, China, SARS-CoV-2 and the associated coronavirus disease 2019 (COVID-19) have become a global pandemic causing significant mortality and morbidity and implementation of strict isolation measures. In the absence of vaccines and effective therapeutics, reliable serological testing must be a key element of public health policy to control further spread of the disease and gradually remove quarantine measures. Serological diagnostic tests are being increasingly used to provide a broader understanding of COVID-19 incidence and to assess immunity status in the population. However, there are discrepancies between claimed and actual performance data for serological diagnostic tests on the market. In this study, we conducted a review of independent studies evaluating the performance of SARS-CoV-2 serological tests. We found significant variability in the accuracy of marketed tests and highlight several lab-based and point-of-care rapid serological tests with high levels of performance. The findings of this review highlight the need for ongoing independent evaluations of commercialized COVID-19 diagnostic tests. View Full-Text
Keywords: COVID-19; serological diagnostic test; SARS-CoV-2; performance COVID-19; serological diagnostic test; SARS-CoV-2; performance
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MDPI and ACS Style

Ghaffari, A.; Meurant, R.; Ardakani, A. COVID-19 Serological Tests: How Well Do They Actually Perform? Diagnostics 2020, 10, 453.

AMA Style

Ghaffari A, Meurant R, Ardakani A. COVID-19 Serological Tests: How Well Do They Actually Perform? Diagnostics. 2020; 10(7):453.

Chicago/Turabian Style

Ghaffari, Abdi, Robyn Meurant, and Ali Ardakani. 2020. "COVID-19 Serological Tests: How Well Do They Actually Perform?" Diagnostics 10, no. 7: 453.

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