Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 22 October 2026 | Viewed by 628
Editor
2. Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20824, USA
Interests: breast cancer; targeted therapy; pan cancer; CART cell therapy; biologics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Regulatory factors and signaling pathways play a crucial role in shaping anti-tumor immune responses, a field of study central to cancer immunotherapy. While treatments like immune checkpoint blockade, vaccines, and T-cell transfer therapy have shown significant promise, their clinical success remains limited to specific cancer types and a minority of patients. This is largely due to the complex interplay of factors within the tumor microenvironment (TME) that can suppress the immune system’s ability to fight cancer. The TME contains a variety of regulatory factors and signaling molecules that can either promote or inhibit immune cell function. A deeper understanding of these intricate pathways is essential for overcoming therapeutic resistance and broadening the applicability of current immunotherapies. Consequently, current research focuses on identifying novel druggable targets and developing combination treatments to modulate these regulatory factors and enhance the body’s anti-tumor immunity.
For this Special Issue, we invite you to contribute original research articles, reviews, or perspective articles on all aspects under the umbrella of “Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses”. Relevant topics include, but are not limited to, the following:
- Anti-tumor immunity;
- Immunotherapy;
- Immune checkpoint blockade;
- Immune receptor and ligand;
- Immune evasion;
- Tumor immune microenvironment;
- Inflammation;
- T-cell activation and inhibition;
- Myeloid-derived suppressor cell;
- Macrophage;
- Dendritic cell.
We look forward to receiving your contributions.
Dr. Geeta Upadhyay
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- anti-tumor immunity
- immunotherapy
- immune checkpoint blockade
- immune receptor and ligand
- immune evasion
- tumor immune microenvironment
- inflammation
- T-cell activation and inhibition
- myeloid-derived suppressor cell
- macrophage
- dendritic cell
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