Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 20 April 2026 | Viewed by 11
Special Issue Editor
2. Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20824, USA
Interests: breast cancer; targeted therapy; pan cancer; CART cell therapy; biologics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Regulatory factors and signaling pathways play a crucial role in shaping anti-tumor immune responses, a field of study central to cancer immunotherapy. While treatments like immune checkpoint blockade, vaccines, and T-cell transfer therapy have shown significant promise, their clinical success remains limited to specific cancer types and a minority of patients. This is largely due to the complex interplay of factors within the tumor microenvironment (TME) that can suppress the immune system’s ability to fight cancer. The TME contains a variety of regulatory factors and signaling molecules that can either promote or inhibit immune cell function. A deeper understanding of these intricate pathways is essential for overcoming therapeutic resistance and broadening the applicability of current immunotherapies. Consequently, current research focuses on identifying novel druggable targets and developing combination treatments to modulate these regulatory factors and enhance the body’s anti-tumor immunity.
For this Special Issue, we invite you to contribute original research articles, reviews, or perspective articles on all aspects under the umbrella of “Regulatory Factors and Signaling Pathways of Anti-Tumor Immune Responses”. Relevant topics include, but are not limited to, the following:
- Anti-tumor immunity;
- Immunotherapy;
- Immune checkpoint blockade;
- Immune receptor and ligand;
- Immune evasion;
- Tumor immune microenvironment;
- Inflammation;
- T-cell activation and inhibition;
- Myeloid-derived suppressor cell;
- Macrophage;
- Dendritic cell.
We look forward to receiving your contributions.
Dr. Geeta Upadhyay
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- anti-tumor immunity
- immunotherapy
- immune checkpoint blockade
- immune receptor and ligand
- immune evasion
- tumor immune microenvironment
- inflammation
- T-cell activation and inhibition
- myeloid-derived suppressor cell
- macrophage
- dendritic cell
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
