Allergy and Immunity

A Special Issue of Cells (ISSN 2073-4409) belonging to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 990

Editors


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Guest Editor
1. Department of Microbiology & Immunology, Touro College of Osteopathic Medicine, Great Falls, MT 59405, USA
2. Department of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA
Interests: allergies; immunology; infectious diseases; translational studies on biomarkers and therapeutic targets for allergic and inflammatory conditions

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Guest Editor
1. Department of Pathology, Microbiology & Immunology, New York Medical College, Valhalla, NY, USA
2. Department of Otolaryngology, New York Medical College, Valhalla, NY, USA
Interests: molecular pathogenesis and immunology of cancer; immunological diseases

Special Issue Information

Dear Colleagues,

Allergic diseases and immune-mediated disorders represent a growing global health burden, driven by complex interactions between genetic, environmental, and immunological factors. Despite significant advances in understanding immune regulation, many of the molecular and cellular mechanisms underlying allergic sensitization, chronic inflammation, and immune dysregulation remain incompletely defined. This Special Issue, "Allergy and Immunity", aims to provide a comprehensive overview of recent progress in the field, spanning fundamental immunology to translational and clinical research. We welcome original research articles, reviews, and communications that explore innate and adaptive immune responses, mechanisms of allergic disease pathogenesis, and emerging biomarkers and therapeutic targets. Emphasis will be placed on studies addressing epithelial–immune interactions, microbiome influences, immune metabolism, novel immunomodulatory strategies, and therapeutics. In addition, this Issue seeks to highlight advances in diagnostic approaches, including in vitro and in vivo models, as well as precision medicine strategies for heterogeneous allergic conditions such as food allergy, asthma, atopic dermatitis, and chronic rhinosinusitis. By bringing together multidisciplinary perspectives, this Special Issue aims to advance the development of innovative therapies to improve patient outcomes in allergy and immune-related diseases.

Dr. Anish R. Maskey
Prof. Dr. Jan Geliebter
Guest Editors

Manuscript Submission Information

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Keywords

  • allergy
  • immune regulation
  • inflammation
  • epithelial barrier
  • biomarker
  • alternate therapy

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Published Papers (1 paper)

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Review

26 pages, 3001 KB  
Review
The Basophil Activation Test in Allergy Diagnostics: Clinical Applications, Methodological Challenges, and Proposed Clinical Frameworks
by Marina Izmailovich, Aizhan Kabyldina, Zamira Seilkhan, Aruzhan Zhussip, Raushan Kozhanova, Tair Nurpeissov, Gulzada Uteubaeva, Olga Kazimirova, Alyona Lavrinenko, Lyubov Brizitskaya, Elina Suleimanova and Zarina Shaikhina
Cells 2026, 15(14), 1241; https://doi.org/10.3390/cells15141241 - 9 Jul 2026
Cited by 1 | Viewed by 642
Abstract
The basophil activation test (BAT) is a modern in vitro functional assay used for the diagnosis of immunoglobulin E-mediated allergic reactions. The method is based on flow cytometric assessment of activation marker expression on peripheral blood basophils after stimulation with specific allergens. BAT [...] Read more.
The basophil activation test (BAT) is a modern in vitro functional assay used for the diagnosis of immunoglobulin E-mediated allergic reactions. The method is based on flow cytometric assessment of activation marker expression on peripheral blood basophils after stimulation with specific allergens. BAT has gained increasing clinical relevance in allergology, particularly in patients with anaphylaxis risk, polysensitization, drug hypersensitivity, and inconclusive skin or serological test results. This narrative review summarizes current evidence on the diagnostic performance and clinical applications of BAT in food allergy, drug hypersensitivity, Hymenoptera venom allergy, latex sensitization, and allergen immunotherapy monitoring. The review discusses the immunological mechanisms of basophil activation, the role of CD63 and CD203c, methodological aspects of the assay, sensitivity and specificity data, and advantages and limitations compared with conventional diagnostic approaches. Particular attention is given to protocol standardization, interpretation criteria, and the problem of non-responder patients. Current evidence indicates that BAT demonstrates high specificity and provides functional assessment of clinically relevant allergic reactions. In addition, this review proposes practical clinical frameworks for integrating BAT into allergy diagnostic pathways and for managing inconclusive or non-responder BAT results. Further standardization, multiplex formats, and automated analytical approaches may expand its role in personalized allergy diagnostics. Full article
(This article belongs to the Special Issue Allergy and Immunity)
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