Advances in Reproductive Biology: Cellular and Molecular Mechanisms

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Reproductive Cells and Development".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 189

Special Issue Editors

Biology Department, Universidad Autonoma of Madrid, C/Darwin nº 2, 28049 Madrid, Spain
Interests: NHEJ; DBS; sperm; fertility; polymorphism; SNP; oxidative stress

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Guest Editor
Research and Development, STGenetics, Navasota, TX, USA
Interests: sperm; fertility; sex-sorting; flow cytometry

Special Issue Information

Dear Colleagues,

Reproductive biology is undergoing a rapid transformation, with major advancements being made in the cellular and molecular mechanisms that govern fertility, development, and reproductive health. Recent research has unveiled critical insights into gametogenesis, fertilization, embryo implantation, and early embryonic development. Cutting-edge technologies, including single-cell sequencing, CRISPR-based genome editing, and organoid models, are reshaping our understanding of reproductive processes at an unprecedented level. Additionally, the molecular pathways regulating hormonal signaling, epigenetic modifications, and cellular interactions are revealing novel therapeutic targets for infertility and reproductive disorders. This Special Issue will bring together innovative research that explores these fundamental biological processes, bridging basic science and clinical applications in reproductive medicine.

Dr. Rosa Roy
Dr. Clara González-Marín
Guest Editors

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Keywords

  • gametogenesis
  • fertilization
  • embryo implantation
  • reproductive genetics
  • epigenetics in reproduction
  • hormonal signaling
  • stem cells and reproduction
  • assisted reproductive technologies (ARTs)
  • molecular fertility regulation
  • reproductive health innovations

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Published Papers (1 paper)

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Research

13 pages, 2310 KiB  
Article
Protein Kinase A Regulates the Cell Cycle to Affect the Induction Rate in the Parthenogenetic Reproduction of the Silkworm, Bombyx mori
by Fang Xu, Wei Yu, Chenkai Ma, Chengjie Hu, Chunguang Cui, Xin Du, Jine Chen, Linbao Zhu, Shaofang Yu, Xingjian He, Yongqiang Wang and Xia Xu
Cells 2025, 14(11), 793; https://doi.org/10.3390/cells14110793 - 28 May 2025
Viewed by 36
Abstract
Protein kinase A (PKA), commonly referred to as cAMP-dependent protein kinase, exists as a heterotetramer composed of two catalytic (C) and regulatory subunits (R). This versatile kinase exhibits regulatory functions in various biological processes including growth, division, and differentiation. Although PKA is well [...] Read more.
Protein kinase A (PKA), commonly referred to as cAMP-dependent protein kinase, exists as a heterotetramer composed of two catalytic (C) and regulatory subunits (R). This versatile kinase exhibits regulatory functions in various biological processes including growth, division, and differentiation. Although PKA is well established as a master regulator of oocyte maturation across species, its functional role in insect parthenogenesis has remained enigmatic. Here, we systematically investigated the regulatory effect of PKA in the induction of parthenogenesis in model lepidopteran Bombyx mori. Our findings demonstrated an inverse correlation between PKA activity and parthenogenetic induction efficiency in silkworms. Notably, PKA activation resulted in delayed embryonic development, whereas PKA-C1 knockdown disrupted normal cell cycle progression. These results indicated that maintaining appropriate PKA activity is essential for ensuring proper cell division process, especially in the successful induction of silkworm parthenogenesis. The evolutionary conservation of PKA across species, coupled with its critical regulatory role in parthenogenesis, positions this kinase as a promising molecular target for breeding design. Our findings establish a foundation for developing silkworm strains with enhanced parthenogenetic capacity through PKA modulation, thereby facilitating the preservation of elite production traits. These results provide novel mechanistic insights into parthenogenesis while demonstrating the potential application of PKA regulation in both genetic studies and breeding programs. Full article
(This article belongs to the Special Issue Advances in Reproductive Biology: Cellular and Molecular Mechanisms)
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