Advances in Annexin Biology
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 28 October 2026 | Viewed by 933
Special Issue Editors
Interests: skin wound healing; angiogenesis; endothelial to mesenchymal and epithelial to mesenchymal transition; cancer biology; cell transfection; in vitro cultures; wound healing in mice; cell migration and invasion; pharmacology in general; extracellular vesicles isolation, characterization and use
Special Issues, Collections and Topics in MDPI journals
Interests: annexin; cancer therapy; cancer biology; metastasis; cellular signaling; endothelial and epithelial-to-mesenchymal transition; extracellular vesicles; tumor microenvironment; biomarkers; skin wound healing
Special Issues, Collections and Topics in MDPI journals
Interests: anti-inflammatory activity; extracellular vesicles; cancer biology; cancer progression; epithelial to mesenchymal transition; cell migration and invasion; tumor microenvironment; in vitro tumor 3D models; tumor biomarkers; cellular behavior in response to pharmacological therapy
Special Issue Information
Dear Colleagues,
Annexins are a fascinating family of proteins that play crucial roles in how cells communicate, adapt, and respond to their environment. By binding to cell membranes in a calcium-dependent manner, annexins are involved in a wide range of cellular processes, including inflammation, membrane repair, signal transduction, apoptosis, and even from cancer development, differentiation to progression. In recent years, interest in annexins has grown significantly thanks to their biological relevance and to advances in high-resolution imaging techniques and the breakthroughs in molecular biology and gene editing tools. Together, these advances have transformed annexins from relatively obscure membrane-associated proteins into dynamic regulators of essential cellular processes. This growing understanding pays the way to new opportunities in the investigation of annexins as potential biomarkers and therapeutic targets in diseases where their expression could be dysregulated and functions notably affected. In this context, an example of one of the most intriguing aspects of annexin biology is their emerging role in tumor progression and in mediating the crosstalk between cancer cells and their surrounding microenvironment, a dynamic network of immune cells, stromal cells, extracellular matrix, and soluble factors. Additionally, annexins are known to further regulate the secretion of inflammatory mediators, extracellular vesicles (like exosomes), and even immune mechanisms both in physiological and pathological systems. By influencing these communication routes, annexins help create a microenvironment that supports tumor growth, angiogenesis, and immune suppression.
This Special Issue, "Advances in Annexin Biology," invites contributions that explore the multifaceted functions of annexins in cell behavior. We welcome original studies, reviews, and communications focused on how annexins act in both normal physiology and disease states. Whether you are studying their molecular mechanisms, interactions with other proteins or lipids, or their potential as therapeutic targets or biomarkers, this Special Issue aims to bring together a broad spectrum of insights.
Dr. Raffaella Belvedere
Prof. Dr. Antonello Petrella
Dr. Nunzia Novizio
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- annexin family
- calcium-dependent membrane binding
- cell signaling
- inflammation and immune response
- membrane repair
- cancer biology
- cell motility
- cell differentiation
- tumor microenvironment
- diagnostic/prognostic biomarkers
- therapeutic targets
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