Interactions Between Gut Microbiota and Epigenetic Markers in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 1244
Editor
Interests: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; inflammatory diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Environmental factors such as microbes, diet, and pharmaceuticals significantly influence the development and progression of various diseases, including cancers, neuropsychiatric, cardiovascular, metabolic, autoimmune, and inflammatory disorders. These complex conditions result from dynamic interactions among the gut microbiota, their metabolites, host genetics, epigenetic regulation, and immune responses. Epigenetic modifications—such as DNA methylation, histone modification, and non-coding RNA regulation—govern key cellular processes like proliferation, apoptosis, inflammation, and immune function, thereby shaping disease onset and progression. Recent evidence highlights that microbiota-derived metabolites, particularly short-chain fatty acids, can modulate epigenetic mechanisms by inhibiting histone deacetylases and altering DNA methylation, ultimately influencing gene expression and critical physiological processes such as immune regulation, mucosal integrity, metabolism, and organ function. This Special Issue of Cells focuses on recent advances in elucidating the interplay between intestinal microbiota and epigenetic regulation in disease pathogenesis and therapy. It welcomes studies exploring how diet and environmental exposures affect health outcomes through epigenetic modulation, as well as mechanistic insights into microbiota–host gene regulation across diverse diseases (cancers, neuropsychiatric disorders, cardiovascular diseases, metabolic diseases, infectious diseases, autoimmune, gastrointestinal, and inflammatory diseases, and opioid addiction). By integrating multidisciplinary research, this Special Issue aims to advance understanding of microbiota–epigenome interactions and foster the development of novel, microbiota-targeted epigenetic therapies for precision medicine.
Dr. Shabnam Nohesara
Guest Editor
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Keywords
- gut microbiome
- epigenetic marks
- cancer
- metabolic diseases
- neuropsychiatric disorders
- inflammatory diseases
- infectious diseases
- cardiovascular diseases
- probiotics
- prebiotics
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